• Differential diagnosis initially included basosquamous carcinoma, acanthoytic squamous cell carcinoma, and adnexal tumor. (cdlib.org)
  • Primary mucinous carcinoma (PMC) of the skin is a rare malignant neoplasm deriving from sweat glands [ 1 ]. (cdlib.org)
  • Although any combination of malignant tumors is possible, reports of MPMs involving cutaneous carcinoma are uncommon in the literature. (bvsalud.org)
  • Herein, we present 2 uncommon cases of synchronous double primary malignancies involving basal cell carcinoma and primary cutaneous mucinous carcinoma as the index tumors, accompanied by a thyroid carcinoma and a thymoma as the second malignancy, respectively. (bvsalud.org)
  • Given these results, the authors discuss the difficulty in diagnosing differentiation from a primary or metastatic neoplasm of the scalp, with the resources currently available, until the conclusion that it was a primary carcinoma of the sweat gland. (bvsalud.org)
  • breast carcinoma, sweat gland carcinoma, skin cancer. (bvsalud.org)
  • This study aimed to report and discuss the challenging differential diagnosis between a primary tumor of sweat glands and cutaneous metastasis of mammary carcinoma using anatomopathological and imaging diagnostic resources available today. (bvsalud.org)
  • The findings show the challenge in differentiating a primary tumor of the sweat gland from a metastatic cutaneous tumor of mammary carcinoma, even with the immunohistochemical resources currently available. (bvsalud.org)
  • Eccrine carcinoma may be derived de novo from any portion of the normal eccrine apparatus or result from the transformation of an existing benign eccrine tumor. (medscape.com)
  • The less common subtypes include eccrine mucinous carcinoma, malignant eccrine spiradenoma, malignant mixed tumor, malignant cylindroma, and papillary eccrine adenoma. (medscape.com)
  • The purpose of this study was to retrospectively evaluate cases of canine anal sac carcinoma and assess the profile of involvement, tumor size, and lymphatic invasion at the time of diagnosis. (pvb.com.br)
  • Eccrine carcinoma is a quite rare malignant tumor that typically arises from a normal sweat gland and that features a rather high recurrence rate subsequent to simple excision. (biomedcentral.com)
  • Even though eccrine carcinomas would appear to be rare, when dealing with recurrent skin tumors or recurrent perianal fistulas, the possibility of eccrine carcinoma should be considered by consulting clinicians. (biomedcentral.com)
  • Eccrine carcinoma is a rare, malignant sweat gland tumor, generally featuring a slow growth rate and a rather high local recurrence rate [ 2 ]. (biomedcentral.com)
  • Sweat gland carcinomas were first reported by Stout and Cooley in 1951 with the observation that, "sweat gland carcinoma often developed at the site of pre-existing nodules of longstanding and they have a propensity to metastasize" [ 2 ]. (biomedcentral.com)
  • Appropriate sweat gland carcinoma classification is clearly important since each of the specific sweat gland carcinomas features its own characteristic biological behavior [ 4 ]. (biomedcentral.com)
  • Squamous cell carcinoma of varying degrees of differentiation is observed in 90% of patients with malignant tumors of the vulva. (med-blog.com)
  • The primary source of metastatic tumors is more oftentotal is squamous cell carcinoma of the cervix, then - cancer of the endometrium, bladder and urethra. (med-blog.com)
  • The etiological classification of squamous cell carcinoma of the vulva includes at least two groups: the smaller - basaloid and warty tumors induced by human papillomaviruses (HPV), and the larger - squamous cell carcinoma, the etiology of which is unknown. (med-blog.com)
  • In the 4th edition of WHO classification of tumors of female reproductive organs, primary villoglandular mucinous adenocarcinoma is defined as a primary invasive glandular epithelial tumor of intestinal type and the synonyms are cloacogenic carcinoma or cloacogenic adenocarcinoma [ 1 ]. (hindawi.com)
  • Pathology and external consultation confirmed syringomatous carcinoma due to the infiltrative growth pattern of a dermal tumor. (appliedradiationoncology.com)
  • Syringomatous carcinoma (SC) is a rare, slow-growing, heterogenous tumor of sweat gland origin. (appliedradiationoncology.com)
  • 3 Histologically, the absence of keratinizing cysts and squamous differentiation (ie, islands with parakeratotic keratinization) distinguish SC from other sclerosing adnexal tumors such as microcystic adnexal carcinoma (MAC) and squamoid eccrine ductal carcinoma (SEDC), respectively. (appliedradiationoncology.com)
  • A rare adnexal carcinoma that is histopathologically identical to homologous lesions in the salivary gland and breast. (nih.gov)
  • Secretory Carcinoma of the Eyelid Arising in an Adnexal Gland. (nih.gov)
  • We report 23 cases of tumors of the salivary gland comprising 18 cases of carcinoma ex pleomorphic adenoma, four cases of carcinosarcoma of the parotid and one case of benign metastasizing pleomorphic adenoma. (ijpmonline.org)
  • Its therapeutic use is limited to the treatment of hypercalcemia and Paget's osteopathy, and as a tumor marker in medullary carcinoma. (teknon.es)
  • while only two microcystic adnexal carcinoma cases (15%) and one squamous cell carcinoma with ductal differentiation (12%) expressed CK7 in the remaining three tumor categories. (dadospdf.com)
  • published online 7 December 2007 histopathologic perspective, the main differential diagnosis for microcystic adnexal carcinoma, a stratified, infiltrating neoplasm characterized by a superficial component of keratinous cysts and a deeper component of smaller nests and strands of cells embedded in a markedly hyalinized stroma, is sclerosing/infiltrative basal cell carcinoma and desmoplastic trichoepithelioma. (dadospdf.com)
  • Objective: Laryngeal verrucous carcinoma (LVC) comprises 1% to 4% of all laryngeal tumors. (researchgate.net)
  • Alterations in the beta-catenin pathway, which is involved in several epidermal tumors, are thought to play a role. (medscape.com)
  • For those that consider this entity to be a tumor, there is further disagreement whether this is a tumor of epidermal, pilar, or sweat gland origin. (statpearls.com)
  • Most experts maintain that clear cell acanthoma is an epidermal tumor, as originally described. (statpearls.com)
  • [ 2 ] examining the incidence of cytogenetic abnormalities in malignant eccrine tumors showed low incidences of loss of heterozygosity (LOH) or TP53 alterations in a mixed group of these neoplasms, in contrast to the frequent and multiple genetic abnormalities seen in tumors arising from epidermal keratinocytes. (medscape.com)
  • were the first to describe tumors exhibiting features of the epidermal sweat duct. (faoj.org)
  • Malignancy arising in mixed tumors of the salivary gland is a distinct entity that can occur sporadically or in association with a background of pleomorphic adenoma. (ijpmonline.org)
  • 1 First described in 1956, poroma was originally identified as a tumor originating from the eccrine sweat gland. (clinicaladvisor.com)
  • Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms . (lookformedical.com)
  • Carcinomas of the eccrine sweat gland represent a rare group of tumors with potential for local destruction and metastasis. (medscape.com)
  • Clinical tumors are characterized by an extremely malignant course in cases where the phasing of lymphogenous metastasis is impaired. (med-blog.com)
  • The specific classification of eccrine carcinomas is both complex and nebulous, mostly because of the paucity of reported cases but also because many of these tumors show little histologic resemblance to mature eccrine glands. (medscape.com)
  • However, research shows UVR is known to suppress sweating, which disrupts body thermoregulation, and a study analyzing TP53 mutations in 16 sweat gland carcinomas identified 3 G:C → A:T transitions at dipyrimidine sequences on the antisense strand. (medscape.com)
  • The first large study pertaining to the classification of sweat gland carcinomas was published in 1968 by Berg and McDivitt [ 3 ]. (biomedcentral.com)
  • Thus, appropriate classification of such sweat glands, and associated tumors, enables us to devise a specific and appropriate sweat gland tumor therapeutical plan, and also an associated precise prognosis, i.e. apocrine carcinomas are able to metastasize to regional lymph nodes and do so frequently, whereas eccrine carcinomas are typically not able to metastasize [ 4 ]. (biomedcentral.com)
  • Unfortunately, as far as we are aware, sweat gland carcinomas are often under diagnosed or misdiagnosed due to their clinical rarity [ 8 ]. (biomedcentral.com)
  • This class of neoplasms includes benign tumors and highly aggressive carcinomas. (ejmjih.com)
  • Intraepidermal Eccrine Adenocarcinomas (IEA) are rare malignant tumors derived from the eccrine sweat glands of the skin. (faoj.org)
  • Poromas are often grouped within the greater classification of acrospiroma, which includes dermal duct tumors, hidroacanthoma simplex, and nodular, clear-cell, and poroid hidradenomas. (clinicaladvisor.com)
  • It's related to acrospiroma (also called poroma), a tumor of the distal part of the sweat gland. (facmedicine.com)
  • Acrospiroma is a cutaneous ailment that appears mainly in women and is a kind of benign adnexal neoplasm linked to poromo, a benign skin tumor. (wordinfo.info)
  • Histologically, a poroma is a well-circumscribed tumor that arises in the lower epidermis and extends into the dermis. (clinicaladvisor.com)
  • ABSTRACT: Multiple primary malignancies (MPMs) refer to the presence of 2 or more histologically distinct malignant tumors in the same individual. (bvsalud.org)
  • The neoplasms may be histologically the same or different, and may be found in the same or different sites. (lookformedical.com)
  • There are three types of sweat glands that occur over the skin surface: eccrine, apocrine and apoeccrine. (biomedcentral.com)
  • Additional benign neoplasms such as trichoepithelioma (8), tubular apocrine adenomas (9), sebaceomas (1), and others have been reported within NS. (aad.org)
  • The degree of differentiation of mast cell tumours (MCTs) is the most important feature and reflects the morphological characteristics and metastatic potential of the tumour and its likely response to treatment and the prognosis. (biomedcentral.com)
  • [2] These tumors clinically present in middle-aged to elderly individuals as an asymptomatic, slowly enlarging, red or red-brown, dome-shaped papule or nodule with a wafer-like scale collarette. (statpearls.com)
  • Clinically, the brain tumor gradually became life threatening without any response to conventional chemotherapies including carboplatin, etoposide, and temozolomide. (nih.gov)
  • Clinically, the most significant histological forms are malignant neoplasms developing from the integumentary squamous epithelium of the external genital organs. (med-blog.com)
  • Spiradenomas arise from the hair follicle bulge rather than the eccrine sweat gland, based on an immunohistochemical study of stem cell markers and with CD200. (medscape.com)
  • This is a unique case due to the low frequency 2 , the atypical clinical history, but mainly the difficult histopathological differential diagnosis and immunohistochemical evaluation among these neoplasms. (bvsalud.org)
  • Immunohistochemical examination of this tumor revealed positive staining for Cytokeratin 20, Mucin 2, and CDX2, although Cytokeratin 7 and Mucin 6 were negative. (hindawi.com)
  • Night sweats are a nonspecific symptom that patients commonly experience but rarely discuss with their physicians without prompting. (aafp.org)
  • Although many life-threatening causes such as malignancies or infections have been described, most patients who report persistent night sweats in the primary care setting do not have a serious underlying disorder. (aafp.org)
  • The presence of night sweats alone does not indicate an increased risk of death. (aafp.org)
  • Night sweats are a common experience, with a prevalence of up to 41% among primary care patients. (aafp.org)
  • 1 The definition of night sweats varies and generally does not require that the symptom be bothersome to the patient. (aafp.org)
  • A systematic review found that the cross-sectional prevalence of night sweats ranges from 10% to 41% in the primary care setting, with the highest prevalence occurring in patients between 41 and 55 years of age. (aafp.org)
  • In a study of school-aged children in China, 12% reported having weekly night sweats during the past year. (aafp.org)
  • A cohort study of 1,534 patients older than 65 years found that after seven years, patients who reported having night sweats were not more likely to die or to die earlier than patients who did not report them. (aafp.org)
  • In one study conducted in the primary care research setting, only 12% of patients who were explicitly asked about night sweats reported the symptom to their physicians. (aafp.org)
  • 1 , 2 One study of 843 patients older than 65 years estimated an annual incidence of 5% (i.e., 5% of patients reported the onset of night sweats during one year). (aafp.org)
  • In the absence of environmental factors, some potential mechanisms for night sweats have been suggested. (aafp.org)
  • Individual patients may be less tolerant of night sweats, or may be awake because of another medical condition and are therefore more likely to notice sweating. (aafp.org)
  • acid-fast bacilli were not visible, and weight loss but no night sweats. (cdc.gov)
  • Abnormal growths of tissue that follow a previous neoplasm but are not metastases of the latter. (lookformedical.com)
  • We present a case with regional lymph node metastases five years after excision of the primary tumour. (regionh.dk)
  • However, only 5% of the lymph nodes were sent along with the primary tumor, indicating the disease's aggressive behavior but with possible metastases underdiagnosed. (pvb.com.br)
  • The leading sign of clinical aggression of a tumor is the presence of its metastases. (med-blog.com)
  • As the depth of tumor invasion increases, the frequency of regional metastases increases. (med-blog.com)
  • Metastases associated with adrenal gland are more prominent in the determination of preexisting neoplasms and underlying adrenal insufficiency. (targetwoman.com)
  • It is a benign congenital hamartoma related to abnormalities of the epidermis, sebaceous glands, sweat glands, and hair follicles. (aad.org)
  • Molecular genetics and immunopathologic analysis of bladder cancer have shown some abnormalities in a number of genes and proteins that have been implicated in the development and progression of such tumors, mainly in the p53 pathway. (ijpmonline.org)
  • Individuals in the United States can also be exposed to radioiodine, primarily 123I and 131I, as a result of clinical procedures in which radioiodine compounds are administered to detect abnormalities of the thyroid gland or to destroy the thyroid gland to treat thyrotoxicosis or thyroid gland tumors. (cdc.gov)
  • They were first described in 1956 by Kersting and Helwig as a distinct form of sweat gland tumor ,which they called eccrine spiradenoma. (medscape.com)
  • In current practice, they are considered to originate from the hair follicle bulge, rather than the sweat gland. (medscape.com)
  • [ 1 ] All 27 spiradenomas and 30 cylindromas in this study were positive for CD200, whereas other tumors thought to be of eccrine lineage were all negative, suggesting that spiradenomas are not eccrine tumors, but rather are follicular tumors derived from the hair follicle bulge and representing the least differentiated follicular tumors. (medscape.com)
  • Most are malignant except the insulin-producing tumors (INSULINOMA). (lookformedical.com)
  • An insulinoma is a rare tumor of the pancreas . (webmd.com)
  • You might hear an insulinoma called a " neuroendocrine tumor " because it starts in special cells in your body called neuroendocrine cells. (webmd.com)
  • The main treatment for an insulinoma is surgery to remove the tumor. (webmd.com)
  • The second neoplasm may have the same or different histological type and can occur in the same or different organs as the previous neoplasm but in all cases arises from an independent oncogenic event. (lookformedical.com)
  • The tumors mostly appear on the face, especially in the folds in the skin between the nose and lips (nasolabial folds, sometimes called smile lines), but may also occur on the neck, scalp, or trunk. (medlineplus.gov)
  • For tumors to develop, a second mutation or deletion of genetic material involving the other copy of the CYLD gene must occur in certain cells during a person's lifetime. (medlineplus.gov)
  • Various malignant skin tumors have been reported to co-occur with BCC at one site [ 3 ]. (e-acfs.org)
  • These tumors occur predominantly on one adrenal gland as an unilateral condition. (targetwoman.com)
  • These tumors occur together with other disorders such as endocrine neoplasia type 2. (targetwoman.com)
  • Sweating may also occur for reasons unrelated to temperature regulation. (aafp.org)
  • [ 7 ] age-related decline in saliva output was found to occur in the stimulated parotid, unstimulated submandibular/sublingual, and stimulated submandibular/sublingual glands. (medscape.com)
  • Additional research suggests that changes may occur in the viscoelasticity of saliva with aging, particularly in saliva produced by the submandibular and sublingual glands. (medscape.com)
  • It is also employed for the detection of malignant tumors including those of the brain, liver, and thyroid gland. (lookformedical.com)
  • Tumors or cancer of the THYROID GLAND. (lookformedical.com)
  • The thyroid gland weighs, on average, 15 g, and is composed of two lateral lobes that extend to the sides of the larynx to very close to the midline of the thyroid cartilage, and that are joined by an isthmus that pass in front of the trachea. (teknon.es)
  • An enlarged thyroid gland ( goiter ) is in the neck just below the Adam's apple. (healthlinkbc.ca)
  • A malignant tumor composed of cells showing differentiation toward sebaceous epithelium. (nih.gov)
  • In epithelial tumors, this marker is also strongly expressed. (histoprime.com)
  • In contrast, non-epithelial tumors do not contain detectable EMA. (histoprime.com)
  • Transfer of a neoplasm from its primary site to lymph nodes or to distant parts of the body by way of the lymphatic system. (lookformedical.com)
  • The outflow of lymph from the posterior parts of the vulva occurs in the inguinal lymph nodes located on the localization side of the tumor, from the anterior sections the outflow occurs in the same lymph nodes and, in addition, through the pre-symphysical plexus to the inguinal lymph nodes located on the opposite side. (med-blog.com)
  • The glands ( lymph nodes ) on either side of the neck, under the jaw, or behind the ears commonly swell when you have a cold or sore throat. (healthlinkbc.ca)
  • Tumors of the cutaneous adnexa arise from, or differentiate toward, structures in normal skin such as hair follicles, sweat ducts/glands, sebaceous glands, or a the disease and results in a specific diagnostic interpretation. (ejmjih.com)
  • Clarification for the origin (either primary or secondary to skin) of the tumor via immunostaining to assess for a myoepithelial in situ component was performed, yielding a negative result. (cdlib.org)
  • The prevalence of MPMs has increased owing to earlier detection of tumors by screening tests and improved treatment modalities for primary tumors. (bvsalud.org)
  • The authors also describe the usefulness of positron emission tomography/computed tomography for detecting occult primary tumors in patients with cutaneous malignancies. (bvsalud.org)
  • Primary malignant neoplasms of the sweat glands are rare, constituting less than 1% of all primary malignant skin lesions 1 . (bvsalud.org)
  • Sox10 and DOG1 Expression in Primary Adnexal Tumors of the Skin. (nih.gov)
  • In some countries, maxillofacial surgeons are also involved in the primary treatment of neoplasm involving the salivary glands. (medscape.com)
  • The prevalence of poroma is not clearly defined, but it is regarded as a relatively rare tumor. (clinicaladvisor.com)
  • Vulvar cancer - a relatively rare tumor. (med-blog.com)
  • In addition, prognostic markers are evaluated and emphasis placed on the pitfalls commonly encountered when evaluating these neoplasms. (edu.au)
  • When two distinct neoplasms are located adjacent to the same cutaneous site, the phenomenon is commonly referred to as a collision tumor [ 1 , 2 ]. (e-acfs.org)
  • Schwannomas are benign, slow-growing peripheral nerve sheath tumors commonly occurring in the head, neck, and flexor regions of the extremities. (koreamed.org)
  • Swollen glands commonly develop when the body fights infections from colds, insect bites, or small cuts. (healthlinkbc.ca)
  • During 2002-2017, the most common incident adrenal gland disorder among male and female service members was adrenal insufficiency and the least common was adrenomedullary hyperfunction. (health.mil)
  • In both sexes, overall rates of other disorders of adrenal gland and Cushing's syndrome were lower than for adrenal insufficiency but higher than for hyperaldosteronism, adrenogenital disorders, and adrenomedullary hyperfunction. (health.mil)
  • In both sexes, the annual rates of adrenal insufficiency and other disorders of adrenal gland increased slightly during the 16-year period. (health.mil)
  • 1 Adrenal insufficiency occurs when the outer portion of the adrenal gland (adrenal cortex) does not produce an adequate amount of cortisol. (health.mil)
  • Multiple familial trichoepithelioma is a condition involving multiple skin tumors that develop from structures associated with the skin (skin appendages), such as hair follicles and sweat glands. (medlineplus.gov)
  • Affected individuals are also at increased risk of developing tumors in tissues other than skin appendages, particularly benign or malignant tumors of the salivary glands. (medlineplus.gov)
  • This book provides a comprehensive, state-of-the-art account of the role of immunohistochemistry in the diagnosis of skin tumors, which is crucial given that overlapping histologic features and unusual morphologic changes can lead to considerable diagnostic uncertainty. (edu.au)
  • Their molecular footprint often reflects the histologic tumor type, and familiarity with these changes will be increasingly necessary for diagnostic and therapeutic considerations. (ejmjih.com)
  • Dentists are involved with aspects of salivary gland function in several ways, such as diagnosing problems involving the major and minor salivary glands, in the management of oral dryness associated with salivary problems, in the treatment of caries and periodontal disease resulting from decreased salivary flow, and in controlling salivation during restorative procedures. (medscape.com)
  • Significant abnormality or disease of the salivary glands, such as that associated with Sjögren syndrome or neoplasm, necessitates additional evaluation by an otolaryngologist or an otolaryngologist/head and neck surgeon for comprehensive treatment of the gland pathology itself. (medscape.com)
  • Autonomic innervation of the salivary glands involves both parasympathetic and sympathetic input. (medscape.com)
  • Ameloblastoma is a benign epithelial odontogenic neoplasm which is common amongst the Yoruba ethinc group. (bvsalud.org)
  • It is unclear whether clear cell acanthoma represents a benign neoplasm or a reactive inflammatory dermatosis. (statpearls.com)
  • The tumor can present as a nodule, cyst, or ulcer. (cdlib.org)
  • Grossly, the resected tumor from vestibule of vagina was papillomatous nodule, 4 × 2 cm in size and yellowish in color (Figure 1 ). (hindawi.com)
  • a) Low-power view of the tumor shows papillomatous nodule. (hindawi.com)
  • The scintigraphic image shows that the nodule may be "hotter" than the rest of the gland, of equal thermal intensity or hypofunctional or cold. (teknon.es)
  • A nodule is usually a growth on a gland. (healthlinkbc.ca)