• Cardio-Metabolic Indices and Metabolic Syndrome as Predictors of Clinical Severity of Gastroenteropancreatic Neuroendocrine Tumors. (ukw.de)
  • Multiple endocrine neoplasia type 1 is a rare genetic syndrome, characterized by the co-occurrence, in the same individual or in related individuals of the same family, of hyperparathyroidism, duodenopancraetic neuroendocrine tumors, pituitary adenomas, adrenocortical tumors, and neuroendocrine tumors (carcinoids) in the thymus, the bronchi, or the stomach. (nih.gov)
  • In MEN1 patients, special attention should be paid to evaluate the progression duodenopancraetic neuroendocrine tumors because of their malignant potential. (nih.gov)
  • Also, thymic neuroendocrine tumors should be detected as soon as possible because they represent the most lethal tumor. (nih.gov)
  • Pheochromocytoma is a rare neuroendocrine tumor of the adrenal medulla. (ctisus.com)
  • Streptozocin chemotherapy for advanced/metastatic well-differentiated neuroendocrine tumors: an analysis of a multi-center survey in Japan. (cancerindex.org)
  • Neuroendocrine tumors (NETs) are believed to be relatively rare and to follow a generally indolent course. (cancerindex.org)
  • Among patients with Cushing's syndrome from excess endogenous production of cortisol, Cushing's disease is the underlying cause in approximately 60 to 70% of patients, independent adrenal production of cortisol in 20 to 30% of patients, and ectopic paraneoplastic neuroendocrine tumors that secrete corticotropin, are the underlying cause in about 6 to 10% of patients. (standardofcare.com)
  • Carcinoid tumors develop from neuroendocrine cells in the gastrointestinal tract (90%), pancreas, pulmonary bronchi, and rarely the genitourinary tract. (msdmanuals.com)
  • In most cases they are nonfunctioning, benign adrenocortical adenomas. (empendium.com)
  • Because of its nonenhanced CT attenuation of less than or equal to 10 HU, a lipid-rich adrenal adenoma may be mimicked by a benign adrenal cyst, or it may be mimicked by a tumor with central cystic and/or necrotic change such as ACC, pheochromocytoma, or metastasis. (ctisus.com)
  • Adrenal adenoma is the most common benign adrenal tumor that arises from the cortex, whereas adrenocortical carcinoma (ACC) is a rare malignant tumor of the cortex. (ctisus.com)
  • In contrast to the approach taken by the ACR, the American Association of Clinical Endocrinologists and American Association of Endocrine Surgeons has taken a more conservative approach and recommend imaging evaluation 3 to 6 months after the initial diagnosis, and then annually for 1 to 2 years for all nodules less than 4 cm, even those with benign characteristics. (ctisus.com)
  • Cushing syndrome from excess endogenous cortisol production may also be caused by a benign or malignant adrenal tumor that secretes cortisol or by a benign or malignant non-pituitary corticotropin secreting tumor. (standardofcare.com)
  • Benign adrenal gland tumors. (the-hospitalist.org)
  • DNA methylation is a comprehensive marker for pediatric adrenocortical tumors. (usp.br)
  • Adrenocortical carcinoma (ACC) is a rare and highly metastatic malignancy. (usz.ch)
  • Background: Hepatocellular carcinoma (HCC) is the most common liver malignancy and the leading cause of death in patients with cirrhosis. (bvsalud.org)
  • Adrenocortical carcinoma (ACC) (also known as adrenal cortical carcinoma) is a rare malignancy with a poor prognosis, affecting 1-2 people per million per year year. (medscape.com)
  • However, they need to undergo a careful clinical and biochemical evaluation for adrenal hormone excess (pheochromocytoma, primary aldosteronism, Cushing syndrome, feminization/virilism) and the risk of malignancy. (empendium.com)
  • Other features such as mass size, heterogeneity, and clinical context (eg, history of hypervascular malignancy or suspicion for pheochromocytoma) must be taken into account when using washout CT. (ctisus.com)
  • Patients found with pituitary incidentalomas can be susceptible to several types of adverse outcomes: hormonal hypersecretion, hypopituitarism, neurologic morbidity due to tumor size, and malignancy in rare cases. (the-hospitalist.org)
  • Palliation of metastatic functioning tumors may be achieved by resection of both the primary tumor and metastatic lesions. (cancer.gov)
  • Biochemical and Genomic Changes of a Devastating Metastatic Medullary Thyroid Cancer. (ucsf.edu)
  • Streptozotocin-induced diabetic ketoacidosis in a patient with metastatic islet-cell carcinoma. (cancerindex.org)
  • A phenotypic map of disseminated hepatocellular carcinoma (HCC) shows clonal constrains in metastatic sites: a morphological study of 88 HCC autopsies. (usp.br)
  • Multiple endocrine neoplastic type 2 is a rare genetic syndrome, characterized by the familial occurrence of medullary thyroid carcinoma either isolated or associated with pheochromocytoma, primary hyperparathyroidism, or typical features (Marfanoid habitus, mucosal neuromas). (nih.gov)
  • A pheochromocytoma (see the image below) is a rare, catecholamine-secreting tumor derived from chromaffin cells. (medscape.com)
  • The term pheochromocytoma (in Greek, phios means dusky, chroma means color, and cytoma means tumor) refers to the color the tumor cells acquire when stained with chromium salts. (medscape.com)
  • Imaging studies should be performed only after biochemical studies have confirmed the diagnosis of pheochromocytoma. (medscape.com)
  • Dr. Soe is an academic endocrinologist who cares for patients with general endocrine disorders, and endocrine neoplasia (tumors of endocrine glands) including thyroid cancers, pheochromocytoma/paraganglioma and other adrenal tumors. (ucsf.edu)
  • A pheochromocytoma (see the image below) is a rare, catecholamine-secreting tumor that may precipitate life-threatening hypertension. (medscape.com)
  • More recent data have shown that these values are not as specific for adenoma as previously believed, since other adrenal tumors such as pheochromocytoma, hypervascular metastases, and ACC also can meet these washout thresholds. (ctisus.com)
  • Biopsies of adrenal masses are not routinely recommended and are only indicated, after exclusion of pheochromocytoma, when an adrenal metastasis of a primary extra-adrenal cancer is suspected or when pathological confirmation of inoperable adrenocortical cancer (ACC) may impact treatment. (bioscientifica.com)
  • ACTH-secreting pituitary adenomas are sporadic tumors in the vast majority of cases, but they can rarely be part of genetic conditions such as multiple endocrine neoplasia type 1 (NEM1), multiple endocrine neoplasia type 4 (NEM4) and familial isolated pituitary adenoma (FIPA) ( 8 8. (scielo.br)
  • The European Society of Endocrinology and the European Network for the Study of Adrenal Tumors has taken a simpler approach and recommend no further follow-up imaging for nodules less than 4 cm with a nonenhanced attenuation of less than 10 HU (ie, those that can be diagnosed as lipid-rich adenomas). (ctisus.com)
  • Corticotropin secreting corticotroph adenomas account for up to 15% of pituitary tumors with an incidence of 1.6 cases per 1 million persons and are typically small, approximately 6 mm in diameter and are 5 to 10 times as common in women as in men. (standardofcare.com)
  • Other less common etiologies of endogenous Cushing's syndrome include ectopic ACTH secretion (EAS ~10%), adrenal adenomas and carcinomas and, more rarely, adrenal primary macronodular adrenal hyperplasia (PMAH) or primary pigmented nodular adrenal disease (PPNAD) ( Table 1 ). (scielo.br)
  • You will be part of a young and dynamic international research group embedded in the interactive and supportive research environment of our Department of Endocrinology, Diabetology and Clinical Nutrition. (usz.ch)
  • Clinical practice guidelines ACC by the European Society of Endocrinology recommend performing a chest CT in addition to an abdominal-pelvic cross-sectional imaging (CT or MRI) in any case where there is high suspicion for ACC. (medscape.com)
  • Management of adrenal incidentalomas: European Society of Endocrinology Clinical Practice Guideline in collaboration with the European Network for the Study of Adrenal Tumors. (empendium.com)
  • Endocrine Meeting 2018 welcomes all the Endocrinologists , Diabetologists, and other medical & clinical experts working the arena of Endocrinology , Metabolic Syndrome and related field to this upcoming Euro Endocrinology Meeting at Paris, France. (endocrineconferences.com)
  • Biochemical assessment aims to detect increased levels of cortisol (24-hour urine, 1 mg dexamethasone suppression test, serum adrenocorticotropic hormone and cortisol), androgens (dehydroepiandrosterone sulfate, testosterone), estrogens (estradiol), and mineralocorticoids (renin, aldosterone). (cancer.gov)
  • High level of serum testosterone, adrenal androgen, plasma ACTH and low basal cortisol are proof of CAH, whereas elevated level of 17-OH pregnenolone is biochemical marker of 3β-HSD enzyme deficiency. (bioscientifica.com)
  • Surgical intervention, aimed at removing the tumor and the source of cortisol or adrenocorticotropic hormone (ACTH), is the optimal treatment in most cases of Cushing's syndrome. (jofem.org)
  • We describe a case of ACC producing cortisol, which was complicated by an acute psychotic episode requiring intravenous etomidate for stabilization of the clinical condition prior to surgery. (jofem.org)
  • Adrenocortical carcinoma (ACC), a rare tumor has the propensity to produce and secrete steroids with the most frequent condition is a cortisol-secreting ACC causing Cushingoid phenotype. (jofem.org)
  • Unilateral, adrenal adenoma, or carcinoma and bilateral micronodular or macro nodular adrenal hyperplasia are the most common causes of Cushing's syndrome due to corticotropin independent, adrenal gland production of cortisol. (standardofcare.com)
  • Clinical presentation varies, in part, related to the extent in duration of cortisol excess. (standardofcare.com)
  • Adachi J , Hirai Y , Terui K , Nakano T , Fukuda Y , Suda T , Sasano H . A report of 7 cases of adrenal tumors secreting both cortisol and aldosterone. (comprehensivephysiology.com)
  • A higher risk of death was associated with increasing age, poorly differentiated tumors, involved margins, and nodal or distant metastases. (medscape.com)
  • It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. (lookformedical.com)
  • In a large patient-population study in the United States, 3982 patients diagnosed with ACC were identified from the National Cancer Data Base (NCDB), and tumor, treatment, and hospital factors associated with survival after resection were examined. (medscape.com)
  • Data set for reporting of carcinoma of the adrenal cortex: explanations and recommendations of the guidelines from the International Collaboration on Cancer Reporting. (ukw.de)
  • Revisions to the International Neuroblastoma Response Criteria: A Consensus Statement From the National Cancer Institute Clinical Trials Planning Meeting. (cancercentrum.se)
  • Dr. Seib has clinical and research expertise in the surgical management of endocrine disorders in older adults, including primary hyperparathyroidism, thyroid cancer, and hyperthyroidism. (stanford.edu)
  • Modern approaches to treating cancer take advantage of critical biochemical differences between cancer cells and normal cells - from radiation therapy to chemotherapy to experimental gene therapy. (janechin.net)
  • E ditor -The Li-Fraumeni syndrome (LFS) is a rare familial cancer syndrome that predisposes gene carriers to the development of diverse early onset malignancies, including soft tissue sarcomas, osteosarcomas, adrenocortical carcinomas, brain tumours, breast carcinomas, and leukaemia, 1-3 with other cancer types occurring less frequently. (bmj.com)
  • Cancer Summit 2020, Conference will focus on educational research directed toward its impact on clinical outcomes, through oral and poster presentations, educational workshop sessions, and influential plenary presentations. (cancersummit.org)
  • According to market study, Market Value for Oncology (i.e. on Organ defined Cancer and Tumors ) will be more than double to $ 623 Million by 2020. (cancersummit.org)
  • Tumors or cancer of the MOUTH. (lookformedical.com)
  • Tumors or cancer of the SKIN . (lookformedical.com)
  • Tumors or cancer of the LUNG. (lookformedical.com)
  • Tumors or cancer of the LIVER. (lookformedical.com)
  • Tumors or cancer of the UTERINE CERVIX. (lookformedical.com)
  • It represents a large group of epithelial lung malignancies which can be divided into two clinical groups: SMALL CELL LUNG CANCER and NON-SMALL-CELL LUNG CARCINOMA . (lookformedical.com)
  • RARITAN, N.J., September 17, 2019 - The Janssen Pharmaceutical Companies of Johnson & Johnson announced today multiple data presentations from its prostate cancer and solid tumor portfolios will be featured at the European Society for Medical Oncology (ESMO) Annual Congress 2019, taking place September 27 to October 1 in Barcelona, Spain. (jnj.com)
  • Janssen is focused on addressing areas of unmet need in both prostate cancer and solid tumors, and this year's ESMO Annual Congress provides an opportunity to share these important study results for both approved and investigational therapies," said Mark Wildgust, Ph.D., Vice President, Global Medical Affairs, Oncology, Janssen Research & Development, LLC. (jnj.com)
  • Patients with clinical indications for ultrasound had their suspected diagnoses recorded before ultrasound testing. (bvsalud.org)
  • Adrenal carcinomas arise from the adrenal cortex and are bilateral in up to 10% of patients. (medscape.com)
  • Patients who have low-grade tumors without evidence of invasion into local tissues or spread to lymph nodes have an improved prognosis. (cancer.gov)
  • Baseline Demographic and Clinical Characteristics of Patients with Adrenal Incidentaloma from a Single Center in China: A Survey. (empendium.com)
  • Most patients are asymptomatic and tend to have a normal biochemical profile. (empendium.com)
  • Our survey showed the clinical benefit and safety of STZ therapy for Japanese patients with unresectable NET. (cancerindex.org)
  • Previous case reports have found that intravenous infusion of etomidate has been useful for patients with adrenocorticotropic hormone (ACTH)-secreting lung tumors, presenting with acute psychosis, although similar reports for patients with glucocorticoid-secreting ACCs are limited [ 4 , 5 ]. (jofem.org)
  • Because Cushing's syndrome is potentially curable, the diagnosis should be pursued in all patients whose clinical course suggests endogenous hypercortisolism. (standardofcare.com)
  • The thyroglobulin (Tg)/ thyroid-stimulating hormone (TSH) ratio has manifested to be a reliable marker for predicting prognosis in patients with differentiated thyroid carcinoma (DTC). (biomedcentral.com)
  • A randomized clinical trial of intravenous methylprednisolone with two protocols in patients with Graves' Orbitopathy. (medscape.com)
  • Screening for hypercortisolism is recommended for patients who present multiple and progressive clinical signs and symptoms, especially those who are considered to be more specific to Cushing's syndrome, abnormal findings relative to age ( e.g. , spinal osteoporosis and high blood pressure in young patients), weight gain associated with reduced growth rate in the pediatric population and for those with adrenal incidentalomas. (scielo.br)
  • Biochemical assessment of Cushing's disease in patients with corticotroph macroadenomas. (scielo.br)
  • Surgical resection of the tumor is the treatment of choice and usually cures the hypertension. (medscape.com)
  • Additionally, performance status (PS) and resection of the primary tumor were observed to influence mOS. (cancerindex.org)
  • A detailed hormonal workup is also recommended to identify potential autonomous excess of glucocorticoids, sex hormones, mineralocorticoids, and adrenocortical steroid hormone precursors. (medscape.com)
  • Hormones and The Heart - Clinical Cases]. (ukw.de)
  • All adrenocortical hormones are steroid compounds derived from cholesterol (see the image below). (medscape.com)
  • It is important to recognize the common tumors associated with LFS on MRI, and it is also important to be aware of the high rate of false-positive lesions. (bvsalud.org)
  • Incidentalomas are mass lesions that are inadvertently discovered during radiolographic diagnostic testing or treatment for other clinical conditions that are unrelated to the incidental mass. (the-hospitalist.org)
  • In recent decades, improvements in radiographic diagnostic techniques and sensitivity have led to increasing discovery of incidental lesions that are often in the absence of clinical signs or symptoms. (the-hospitalist.org)
  • Broad categories of etiologies should be considered: pituitary adenoma, nonpituitary tumors, vascular lesions, infiltrative disorders, and others (see Table 2). (the-hospitalist.org)
  • Scintigram obtained by using iodine-131-beta-iodomethyl-norcholesterol (NP-59) in a 59-year-old man with hypertension shows fairly intense radionuclide uptake in the right adrenal tumor. (medscape.com)
  • In MEN2, calcitonin and carcinoembryonic antigen (CEA) serve as excellent tumor markers for medullary thyroid carcinoma. (nih.gov)
  • This research is a continuation of the work I led in Sydney which identified tumour and blood markers and resulted in a phase I clinical trial of microRNA replacement therapy (NCT 02369198). (otago.ac.nz)
  • These tumor models display varied molecular, biochemical and mutational signatures that closely mimics the clinical situation. (usz.ch)
  • Integrating methylome and transcriptome signatures expands the molecular classification of the pituitary tumors. (usp.br)
  • The heterogeneous clinical presentation, unexplored molecular background and lack of prostate biopsies complicate therapy. (oncotarget.com)
  • Leukemia and tumors of the brain, soft tissues, breasts, adrenal glands, and bone are the most common cancers associated with this syndrome. (bvsalud.org)
  • An obvious requirement for the stringent control of cell cycle progression is the prevention of deregulated proliferation - loss of control may result in tumors and cancers. (janechin.net)
  • Children with mutation in the RET gene should have prophylactic total thyroidectomy according to the category of aggressiveness of the detected mutation whereas those with clinical MEN2 should be operated on upon diagnosis. (nih.gov)
  • Adrenocortical carcinoma (ACC) is a rare tumor with an annual incidence of 2 cases per 1 million population. (cancer.gov)
  • Needle tract seeding is a potential, albeit rare, complication following transcutaneous biopsies, leading to the seeding of tumor cells along the path of the needle. (bioscientifica.com)
  • Adrenocortical carcinoma (ACC) is rare with an incidence of 0.7 - 2.0 per million per year. (jofem.org)
  • Cushing's disease (CD) is a rare clinical condition that is due to ACTH-producing pituitary adenoma, and it is the most common etiology of endogenous Cushing's syndrome after 6 yrs of age (~70%) ( 2 2. (scielo.br)
  • Less than 1% of people with Cushing's syndrome have a tumor that secretes corticotropin releasing hormone. (standardofcare.com)
  • Most cases of Cushing's disease are the result of microadenomas, particularly tumors smaller than 6 mm, which are difficult to identify on imaging studies. (standardofcare.com)
  • Subjects with clinical MEN1 and those who carry a mutation in the MEN1 gene should be offered biochemical and imaging screening in order to detect tumors and evaluate their progression over time. (nih.gov)
  • Comparative biochemical studies of rapamycin and wortmannin on transforming growth factor-beta 1 (TGF-beta1)-mediated G(1)-S cell cycle progression in C3H-10T1/2 embryonic fibroblasts. (janechin.net)
  • Therefore, understanding biochemical dynamics of cell cycle progression may lead to target-specific therapy with improved side effect profiles. (janechin.net)
  • GABRB2 is associated with a spectrum of neuropsychiatric disorders, and displays of differential gene expression between tumor and non tumor tissues. (wikipedia.org)
  • The patient demographics, tumor characteristics, context of STZ chemotherapy, and patient outcome were collected and assessed. (cancerindex.org)
  • A lesion with cytological characteristics associated with invasive carcinoma but the tumor cells are confined to the epithelium of origin, without invasion of the basement membrane. (lookformedical.com)
  • Clinical and biochemical characteristics of adrenocorticotropin-secreting macroadenomas. (scielo.br)
  • The goals of treatment in ACC include both control of tumor growth and mitigation of the effects derived from the production of hormone excess, as hypercortisolism may lead to poor quality of life and precocious death. (jofem.org)
  • 5 A detailed history and physical examination should be obtained with specific inquiry as to signs and symptoms of hormonal excess and mass effect from the tumor. (the-hospitalist.org)
  • Although pheochromocytomas have classically been associated with 3 syndromes-von Hippel-Lindau (VHL) syndrome, multiple endocrine neoplasia type 2 (MEN 2), and neurofibromatosis type 1 (NF1)-there are now 10 genes that have been identified as sites of mutations leading to these tumors. (medscape.com)
  • In addition to studying genes, genetic testing in a broader sense includes biochemical tests for the presence or absence of key proteins that signal aberrant gene function. (healthywomen.org)
  • median age 36.8, range 20-69), considering biochemical parameters of blood and ejaculates, and epigenetic regulation of the estrogen receptor genes ( ESR1 and ESR2 ) in leukocytes isolated from blood (systemic regulation) and in somatic cells isolated from ejaculates (local regulation). (oncotarget.com)
  • Additional screens for MMTV provirus entry sites in tumors revealed several other upregulated genes that are associated with other gene development pathways such as INT2, INT3, and INT4 [4,5,6]. (chemdiv.com)
  • It can affect individuals at any age, but it is most prevalent in the second and third decades of life and is mostly (~80-90%) caused by pituitary tumors with a diameter less than 10 mm (microadenomas) ( 5 5. (scielo.br)
  • All adrenocortical steroids are degraded in the liver and predominantly conjugated to glucuronides, with lesser amounts of sulfates formed. (medscape.com)
  • The tumor is malignant in 10% of cases but may be cured completely by surgical removal. (medscape.com)
  • When such tumors arise outside of the adrenal gland, they are termed extra-adrenal pheochromocytomas, or paragangliomas. (medscape.com)
  • An anaplastic, highly malignant, and usually bronchogenic carcinoma composed of small ovoid cells with scanty neoplasm. (lookformedical.com)
  • The majority of classical LFS families harbour germline mutations of the p53 tumour suppressor gene. (bmj.com)
  • Adrenocortical carcinoma (ACC) can be classified into functioning and nonfunctioning tumors by clinical and biochemical assessment. (cancer.gov)
  • Pathological assessment can differentiate high-grade and low-grade tumors according to the mitotic activity of the tumor. (cancer.gov)
  • When clinical, biochemical, and radiologic studies are discordant or equivocal, bilateral inferior petrosal sinus sampling should be performed. (standardofcare.com)