Acetogenins
Annona
Annonaceae
Furans
Uvaria
Benzethonium
Lactones
Laurencia
Electron Transport Complex I
Inhibitory activities of three annonaceous acetogenins on NADH oxidase of chicken liver mitochondria. (1/25)
Annonaceous acetogenins (ACG) are natural products found in the plant family Annonaceae and which strongly inhibited mitochondrial complex I. The inhibition of NADH oxidase of chicken liver mitochondria by three different structural ACG was studied here, and ACG was shown to have potent inhibitory activities similar to rotenone for NADH oxidase. The IC(50) values indicated that bis-adjacent tetrahydrofuran (THF) type squamocin C was more potent than non-adjacent bis-THF type squamostatin B, and the latter was more potent than non-THF type compound 1 in the assay. The roles of structural factors of ACG such as the terminal gamma-lactone, the features of other ring moieties and hydroxyl groups, as well as the alkyl chain were simply discussed in this study. (+info)Differential cytotoxic effects of Annona squamosa seed extracts on human tumour cell lines: role of reactive oxygen species and glutathione. (2/25)
Annonaceous acetogenins are a new class of compounds that have been reported to have potent pesticidal, parasiticidal, anti-microbial, cell growth inhibitory activities. In this study, organic and aqueous extracts from the defatted seeds of Annona squamosa (custard apple) were tested on different human tumour cell lines for antitumoural activity. While organic and aqueous extracts induced apoptosis in MCF-7 and K-562 cells, they failed to do so in COLO-205 cells. Treatment of MCF-7 and K-562 cells with organic and aqueous extracts resulted in nuclear condensation, DNA fragmentation, induction of reactive oxygen species (ROS) generation and reduced intracellular glutathione levels. In addition downregulation of Bcl-2 and PS externalization by Annexin-V staining suggested induction of apoptosis in MCF-7 and K-562 cells by both the extracts through oxidative stress. On the contrary, COLO-205 cells showed only PS externalization but no change in ROS and glutathione levels. These observations suggest that the induction of apoptosis by A. squamosa extracts can be selective for certain types of cancerous cells. (+info)REM sleep behavior disorder in patients with guadeloupean parkinsonism, a tauopathy. (3/25)
STUDY OBJECTIVE: To describe sleep characteristics and rapid eye movement (REM) sleep behavior disorder in patients with Guadeloupean atypical parkinsonism (Gd-PSP), a tauopathy resembling progressive supranuclear palsy that mainly affects the midbrain. It is possibly caused by the ingestion of sour sop (corossol), a tropical fruit containing acetogenins, which are mitochondrial poisons. DESIGN: Sleep interview, motor and cognitive tests, and overnight videopolysomnography. PATIENTS: Thirty-six age-, sex-, disease-duration- and disability-matched patients with Gd-PSP (n = 9), progressive supranuclear palsy (a tauopathy, n = 9), Parkinson disease (a synucleinopathy, n = 9) and controls (n = 9). SETTINGS: Tertiary-care academic hospital. RESULTS: REM sleep behavior disorder was found in 78% patients with Gd-PSP (43% of patients reported having this disorder several years before the onset of parkinsonism), 44% of patients with idiopathic Parkinson disease, 33% of patients with progressive supranuclear palsy, and no controls. The percentage of muscle activity during REM sleep was greater in patients with Gd-PSP than in controls (limb muscle activity, 8.3%+/-8.7% vs 0.1%+/- 0.2%; chin muscle activity, 24.3%+/- 23.7% vs 0.7%+/-2.0%) but similar to that of other patient groups. The latency and percentage of REM sleep were similar in patients with Gd-PSP, patients with Parkinson disease, and controls, whereas patients with progressive supranuclear palsy had delayed and shortened REM sleep. CONCLUSION: Although Gd-PSP is a tauopathy, most patients experience REM sleep behavior disorder. This suggests that the location of neuronal loss or dysfunction in the midbrain, rather than the protein comprising the histologic lesions (synuclein versus tau aggregation), is responsible for suppressing muscle atonia during REM sleep. Subjects with idiopathic REM sleep behavior disorder should avoid eating sour sop. (+info)Synthesis of annonaceous acetogenins from muricatacin. (4/25)
Synthetic studies of annonaceous acetogenins starting from (-)-muricatacin (1a) or (+)-muricatacin are described, involving (-)-muricatacin (1a), mono-THF acetogenin, solamin (2), reticulatacin (3), (15R, 16R, 19S, 20S)-cis-solamin (4a) and (15S, 16S, 19R, 20R)-cis-solamin (4b), non-adjacent bis-THF acetogenin, 4-deoxygigantecin (5), and epoxide-bearing acetogenin, (15S, 16R, 19S, 20R)-diepomuricanin (6a). (+info)Anthelmintic acetogenin from Annona squamosa L. Seeds. (5/25)
Annona squamosa seeds extracts showed anthelmintic activity against Haemonchus contortus, the main nematode of sheep and goat in Northeastern Brazil. A compound 1 was isolated from ethyl acetate extract and inhibited the egg hatching of H. contortus at 25 mg ml(-1). The structure of 1 was determined as a C37 trihydroxy adjacent bistetrahydrofuran acetogenin based on spectroscopic analysis. (+info)Synthesis and antitumor activity of C-9 epimers of the tetrahydrofuran containing acetogenin 4-deoxyannoreticuin. (6/25)
(+info)Halogenated terpenes and a C(15)-acetogenin from the marine red alga Laurencia saitoi. (7/25)
(+info)Genotoxic and cytotoxic effects produced by acetogenins obtained from Annona cherimolia Mill. (8/25)
In the present study we extracted three isomeric acetogenins (Ace) from the seeds of Annona cherimolia Mill. (Annonaceae) and determined their genotoxic and cytotoxic potential in mice. Our results showed a significant increase in the rate of micronucleated polychromatic erythrocytes induced by Ace with respect to the value for the control group; the effect was less pronounced than that observed with daunorubicin (Dau). To evaluate cytotoxicity, we determined the proportion of polychromatic erythrocytes with respect to the number of normochromatic erythrocytes, and we found an inhibitory effect induced by Ace that was quite similar to that observed with Dau. Besides, by means of the 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide test, we also determined the cytotoxicity of Ace in both a normal fibroblast mouse cell line and in a line derived from human colon cancer. In this assay, the strongest decrease in viability corresponded to the malignant cell line. Our results established for the first time the genotoxic capacity of these compounds in vivo, and confirmed their cytotoxic potential in cultured cells. (+info)Acetogenins are a type of compound that are produced by certain plants, particularly those in the family Annonaceae. They are known for their potential medicinal properties, including anti-cancer, anti-malarial, and insecticidal activities. Acetogenins have a complex structure, consisting of a long chain of carbon atoms with various functional groups attached. They work by inhibiting the function of certain enzymes that are necessary for the survival of cancer cells and other target organisms.
"Annona" is a genus of plants in the custard apple family, Annonaceae. It includes several species that produce edible fruit, such as Annona squamosa (sugar-apple or sweetsop), Annona reticulata (custard apple or bullock's heart), and Annona cherimola (cherimoya). These fruits are native to tropical regions of the Americas and have been cultivated for their sweet, aromatic flesh.
In a medical context, "Annona" is not commonly used as a term. However, some research has investigated the potential medicinal properties of compounds found in Annona species. For example, acetogenins found in the seeds and bark of certain Annona species have been studied for their potential anti-cancer, insecticidal, and anti-malarial properties.
It's worth noting that while some research has suggested that these compounds may have therapeutic potential, more studies are needed to confirm their safety and efficacy in humans. Additionally, it's important to note that the seeds and bark of Annona species can be toxic if ingested in large quantities, so they should not be consumed without medical supervision.
Annonaceae is a family of flowering plants, also known as custard apple family. It includes several genera and species of tropical trees and shrubs that are native to the Americas, Africa, Asia, and Australia. The plants in this family are characterized by their large, often fragrant flowers and fleshy fruits. Some of the commercially important crops in this family include cherimoya, soursop, custard apple, and pawpaw. Many species of Annonaceae have also been studied for their potential medicinal properties, including the presence of alkaloids with anticancer and anti-malarial activities.
Furans are not a medical term, but a class of organic compounds that contain a four-membered ring with four atoms, usually carbon and oxygen. They can be found in some foods and have been used in the production of certain industrial chemicals. Some furan derivatives have been identified as potentially toxic or carcinogenic, but the effects of exposure to these substances depend on various factors such as the level and duration of exposure.
In a medical context, furans may be mentioned in relation to environmental exposures, food safety, or occupational health. For example, some studies have suggested that high levels of exposure to certain furan compounds may increase the risk of liver damage or cancer. However, more research is needed to fully understand the potential health effects of these substances.
It's worth noting that furans are not a specific medical condition or diagnosis, but rather a class of chemical compounds with potential health implications. If you have concerns about exposure to furans or other environmental chemicals, it's best to consult with a healthcare professional for personalized advice and recommendations.
"Uvaria" is not a term that has a widely accepted medical definition. It is a genus of flowering plants in the family Annonaceae, commonly known as the custard apple family. Some species of Uvaria are used in traditional medicine in various parts of the world, but there is limited scientific evidence to support their effectiveness or safety.
If you have any specific medical concern related to a plant or substance in the Uvaria genus, I would recommend consulting with a healthcare professional for accurate information and guidance.
Benzethonium is an antimicrobial agent used as a preservative in some pharmaceutical and cosmetic products. It has broad-spectrum activity against gram-positive and gram-negative bacteria, fungi, and viruses. The chemical name for benzethonium chloride is N'-(1-benzyl-4-phenoxypyridinio) decane methosulfate.
Benzethonium chloride is commonly used as a topical antiseptic in products such as skin cleansers, hand sanitizers, and first aid treatments. It works by disrupting the bacterial cell membrane, leading to the death of the microorganism. However, it may not be effective against some spores and highly resistant bacteria.
It is important to note that benzethonium chloride should be used according to the instructions on the product label and should not be ingested or used in the eyes or mucous membranes unless specifically directed by a healthcare professional.
Lactones are not a medical term per se, but they are important in the field of pharmaceuticals and medicinal chemistry. Lactones are cyclic esters derived from hydroxy acids. They can be found naturally in various plants, fruits, and some insects. In medicine, lactones have been used in the synthesis of drugs, including certain antibiotics and antifungal agents. For instance, the penicillin family of antibiotics contains a beta-lactone ring in their structure, which is essential for their antibacterial activity.
I apologize for any confusion, but "Laurencia" is not a commonly used medical term or diagnosis. It is possible that you may be referring to "Laurasia," which is a geological supercontinent that existed during the early Mesozoic Era, but it is not a medical concept. If you have a different context or meaning in mind, please provide more information so I can give a more accurate response.
Electron Transport Complex I, also known as NADH:ubiquinone oxidoreductase, is a large protein complex located in the inner mitochondrial membrane of eukaryotic cells and the cytoplasmic membrane of prokaryotic cells. It is the first complex in the electron transport chain, a series of protein complexes that transfer electrons from NADH to oxygen, driving the synthesis of ATP through chemiosmosis.
Complex I consists of multiple subunits, including a flavin mononucleotide (FMN) cofactor and several iron-sulfur clusters, which facilitate the oxidation of NADH and the reduction of ubiquinone (coenzyme Q). The energy released during this electron transfer process is used to pump protons across the membrane, creating a proton gradient that drives ATP synthesis.
Defects in Complex I can lead to various mitochondrial diseases, including neurological disorders and muscle weakness.
Acetogenin
Annona bullata
Phytochemical Analysis
Goniothalamus giganteus
Medicinal plants
Phytochemistry
Uvaricin
Annonaceae
Annonin
Bullatacin
Annona squamosa
Jerry L. McLaughlin
Mitrephora maingayi
Chamuvarinin
Cananga brandisiana
Asimina triloba
Annonacin
Oxonium ion
Goniothalamus undulatus
Molvizarin
Cherimoya
Annonamine
Asimina
Tetrahydrofuran
Annona jahnii
Plasminogen activator inhibitor-1
Respiratory complex I
Magnoliids
Annona
Uvariopsis congensis
Acetogenin - Wikipedia
Total synthesis of the potent antitumor, bis-tetrahydrofuranyl annonaceous acetogenins (+)-asimicin and (+)-bullatacin<...
Metabólitos secundários de Annonaceae: triagem, fracionamento biomonitorado e bioatividade...
Annonaceous acetogenin mimic AA005 induces cancer cell death via apoptosis inducing factor through a caspase-3-independent...
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Downloadable Resources for Health Information
medical science - Does soursop cure cancer? - Skeptics Stack Exchange
DeCS 2017 - July 04, 2017 version
CICECO Publication » Potential anti-Acanthamoeba and anti-adhesion activities of Annona muricata and Combretum trifoliatum...
Annonaceous8
- Hoye, TR & Tan, L 1995, ' Total synthesis of the potent antitumor, bis-tetrahydrofuranyl annonaceous acetogenins (+)-asimicin and (+)-bullatacin ', Tetrahedron Letters , vol. 36, no. 12, pp. 1981-1984. (umn.edu)
- Annonaceous acetogenins are a family of natural products with antitumor activities. (biomedcentral.com)
- Annonaceous acetogenin mimic AA005 reportedly inhibits mammalian mitochondrial NADH-ubiquinone reductase (Complex I) and induces gastric cancer cell death. (biomedcentral.com)
- The studies concentrate on the antitumor properties and selective toxicity of annonaceous acetogenins. (pearltrees.com)
- New cytotoxic monotetrahydrofuran annonaceous acetogenins from Annona muricata. (vitanatural.net)
- 6. Oberlies NH, Chang CJ, McLaughlin JL (1997) Structure-activity relationships of diverse Annonaceous acetogenins against multidrug resistant human mammary adenocarcinoma (MCF-7/Adr) cells. (vitanatural.net)
- What is factual and proven through scientific study is that the soursop, with its annonaceous acetogenins is more effective in targeting the cells that cancer patients want to target ie the cancer cells. (stackexchange.com)
- Identification of Annonaceous Acetogenins and Alkaloids from the Leaves, Pulp, and Seeds of Annona atemoya . (bvsalud.org)
Graviola7
- More recent scientific studies suggest that acetogenins, the active constituents of graviola, can support healthy cell growth and function. (allstarhealth.com)
- Multiple research studies have discovered beneficial acetogenins in the Graviola plant. (raintree.com)
- Graviola leaf powder consists of a specialized substance named as acetogenins. (moringaforwholesale.com)
- These acetogenins are the substance, which helps the Graviola to perform the anti-cancer function of them. (moringaforwholesale.com)
- The acetogenins produced from the Graviola leaf powder, helps you in the treatment of more than one type of cancer, which includes pancreatic cancer, breast cancer, prostate cancer, liver cancer, lung cancer and lymphomas. (moringaforwholesale.com)
- However, the acetogenins produced or extracted from the Graviola leaf powder , easily replaces the need for the other potent anti-cancer treatment. (moringaforwholesale.com)
- Source of acetogenins anti-cancer, graviola in capsules, powder and infusions. (linkorado.com)
Alkaloids2
- It's particularly rich in alkaloids, phenols, and acetogenins. (gaiaverso.org)
- Phenols, alkaloids and acetogenins are the most important and effective compounds. (asianjab.com)
Soursop3
- Purified acetogenins and crude extracts of the common North American pawpaw (Asimina triloba) or the soursop (Annona muricata) remain under laboratory studies. (wikipedia.org)
- Pure Soursop Leaf Annona muricata Extract must have Acetogenins! (bionutriciaextract.com)
- Without Acetogenins, it's not Soursop Leaf Annona muricata! (bionutriciaextract.com)
Potent inhibitors1
- It has a wide potent anticancerous agents coined as Acetogenins which play a key role towards many varieties of cancer, Acetogenins are potent inhibitors of NADH oxidase of the plasma membranes of cancer cells. (ingentaconnect.com)
Inhibit3
- Acetogenins inhibit NADH dehydrogenase, a key enzyme in energy metabolism. (wikipedia.org)
- The acetogenins from the paw paw plant inhibit ATP production in cancer cells, depriving them of the energy they need to sustain their rapid metabolism. (treelite.com)
- Oberlies et al (1995) researched the capability of acetogenins to block, or inhibit, the cell growth of tumor cells. (guyabano.com)
Compounds2
- Examples include: Annonacin Annonins Bullatacin Uvaricin Structurally, acetogenins are a series of C-35/C-37 compounds usually characterized by a long aliphatic chain bearing a terminal methyl-substituted α,β-unsaturated γ-lactone ring, as well as one to three tetrahydrofuran (THF) rings. (wikipedia.org)
- Plagioneurin B belongs to acetogenin group has well-established class of compounds. (um.edu.my)
Cytotoxic1
- Two new cytotoxic acetogenins from Annona squamosa . (tramil.net)
NADH1
- Natural substances (acetogenins) from the family Annonaceae are powerful inhibitors of mitochondrial NADH dehydrogenase (Complex I)". Biochemical Journal. (wikipedia.org)
Annonaceae3
- Acetogenins are a class of polyketide natural products found in plants of the family Annonaceae. (wikipedia.org)
- Recent Progress on the Total Synthesis of Acetogenins from Annonaceae" (PDF). (wikipedia.org)
- Acetogenins from Annonaceae. (wikipedia.org)
Toxicity1
- These findings can indicate that acetogenins can selectively block the cell growth of tumor cells, while the healthy cells remain unaffected with minimal toxicity by this compound. (guyabano.com)
Antioxidants2
- Its main antioxidants are acetogenins and quercetin. (pharmavita.eu)
- Furthermore, guyabano is loaded with antioxidants such as acetogenins and flavonoids. (agraryo.com)
Chemicals2
- The smell is due to a mixture of chemicals, and among these are the acetogenins. (cincynature.org)
- It contains hundreds of chemicals called acetogenins. (whatsdalatest.com)
Cells4
- Acetogenins from the stems of Uvaria micrantha showing antiproliferative effects on HepG2 liver cancer cells. (cri.or.th)
- Acetogenin group has attracted worldwide attention in the past few years due their biological abilities as inhibitors for several types of tumour cells. (um.edu.my)
- Results showed that the more acetogenins was added with the cancerous cells, the more the cell growth was blocked. (guyabano.com)
- In addition, the non-cancerous healthy cells were not affected by the acetogenins and the cell growth was not blocked. (guyabano.com)
Leaves3
- Muricoreacin and murihexocin C, mono-tetrahydrofuran acetogenins, from the leaves of Annona muricata. (vitanatural.net)
- The plant has a strong antibiotic power due to its acetogenin content, especially in the leaves and seeds. (botanical-online.com)
- The tree produces these 'acetogenins' in the leaves, stem and bark. (guyabano.com)
Quantities1
- What everyone would like is to make these acetogenins in big quantities, to help everyone. (guyabano.com)
Fact1
- In fact, the zebra swallowtail actually sequesters the acetogenins in its body, rendering it toxic to animals that would otherwise eat it-similar to how monarchs use toxins from milkweeds. (cincynature.org)
Properties1
- Acetogenins have been investigated for their biological properties, but are a concern due to neurotoxicity. (wikipedia.org)