Polyketides of up to a few dozen carbons in length, formed by chain extension of multiple PROPIONATES and oxygenated to form tetrahydrofuran and lactone rings along the length of the chain. They are found in ANNONACEAE and other PLANTS. Related compounds cyclize to MACROLIDES.
A plant genus of the family ANNONACEAE. It has edible fruit and seeds which contain acetogenins and benzoquinazoline and other alkaloids.
The custard-apple plant family of the order Magnoliales, subclass Magnoliidae, class Magnoliopsida. Some members provide large pulpy fruits and commercial timber. Leaves and wood are often fragrant. Leaves are simple, with smooth margins, and alternately arranged in two rows along the stems.
Compounds with a 5-membered ring of four carbons and an oxygen. They are aromatic heterocycles. The reduced form is tetrahydrofuran.
A plant genus of the family ANNONACEAE. Members contain uvarigrin, uvarigrandin, chamuvaritin and other acetogenins and benzylisoquinoline alkaloids.
Bactericidal cationic quaternary ammonium surfactant used as a topical anti-infective agent. It is an ingredient in medicaments, deodorants, mouthwashes, etc., and is used to disinfect apparatus, etc., in the food processing and pharmaceutical industries, in surgery, and also as a preservative. The compound is toxic orally as a result of neuromuscular blockade.
Cyclic esters of hydroxy carboxylic acids, containing a 1-oxacycloalkan-2-one structure. Large cyclic lactones of over a dozen atoms are MACROLIDES.
A genus of RED ALGAE in the family Rhodomelaceae. Some species are a rich source of chlorine-and bromine-containing metabolites which show significant antibacterial activity.
A flavoprotein and iron sulfur-containing oxidoreductase complex that catalyzes the conversion of UBIQUINONE to ubiquinol. In MITOCHONDRIA the complex also couples its reaction to the transport of PROTONS across the internal mitochondrial membrane. The NADH DEHYDROGENASE component of the complex can be isolated and is listed as EC 1.6.99.3.

Inhibitory activities of three annonaceous acetogenins on NADH oxidase of chicken liver mitochondria. (1/25)

Annonaceous acetogenins (ACG) are natural products found in the plant family Annonaceae and which strongly inhibited mitochondrial complex I. The inhibition of NADH oxidase of chicken liver mitochondria by three different structural ACG was studied here, and ACG was shown to have potent inhibitory activities similar to rotenone for NADH oxidase. The IC(50) values indicated that bis-adjacent tetrahydrofuran (THF) type squamocin C was more potent than non-adjacent bis-THF type squamostatin B, and the latter was more potent than non-THF type compound 1 in the assay. The roles of structural factors of ACG such as the terminal gamma-lactone, the features of other ring moieties and hydroxyl groups, as well as the alkyl chain were simply discussed in this study.  (+info)

Differential cytotoxic effects of Annona squamosa seed extracts on human tumour cell lines: role of reactive oxygen species and glutathione. (2/25)

Annonaceous acetogenins are a new class of compounds that have been reported to have potent pesticidal, parasiticidal, anti-microbial, cell growth inhibitory activities. In this study, organic and aqueous extracts from the defatted seeds of Annona squamosa (custard apple) were tested on different human tumour cell lines for antitumoural activity. While organic and aqueous extracts induced apoptosis in MCF-7 and K-562 cells, they failed to do so in COLO-205 cells. Treatment of MCF-7 and K-562 cells with organic and aqueous extracts resulted in nuclear condensation, DNA fragmentation, induction of reactive oxygen species (ROS) generation and reduced intracellular glutathione levels. In addition downregulation of Bcl-2 and PS externalization by Annexin-V staining suggested induction of apoptosis in MCF-7 and K-562 cells by both the extracts through oxidative stress. On the contrary, COLO-205 cells showed only PS externalization but no change in ROS and glutathione levels. These observations suggest that the induction of apoptosis by A. squamosa extracts can be selective for certain types of cancerous cells.  (+info)

REM sleep behavior disorder in patients with guadeloupean parkinsonism, a tauopathy. (3/25)

STUDY OBJECTIVE: To describe sleep characteristics and rapid eye movement (REM) sleep behavior disorder in patients with Guadeloupean atypical parkinsonism (Gd-PSP), a tauopathy resembling progressive supranuclear palsy that mainly affects the midbrain. It is possibly caused by the ingestion of sour sop (corossol), a tropical fruit containing acetogenins, which are mitochondrial poisons. DESIGN: Sleep interview, motor and cognitive tests, and overnight videopolysomnography. PATIENTS: Thirty-six age-, sex-, disease-duration- and disability-matched patients with Gd-PSP (n = 9), progressive supranuclear palsy (a tauopathy, n = 9), Parkinson disease (a synucleinopathy, n = 9) and controls (n = 9). SETTINGS: Tertiary-care academic hospital. RESULTS: REM sleep behavior disorder was found in 78% patients with Gd-PSP (43% of patients reported having this disorder several years before the onset of parkinsonism), 44% of patients with idiopathic Parkinson disease, 33% of patients with progressive supranuclear palsy, and no controls. The percentage of muscle activity during REM sleep was greater in patients with Gd-PSP than in controls (limb muscle activity, 8.3%+/-8.7% vs 0.1%+/- 0.2%; chin muscle activity, 24.3%+/- 23.7% vs 0.7%+/-2.0%) but similar to that of other patient groups. The latency and percentage of REM sleep were similar in patients with Gd-PSP, patients with Parkinson disease, and controls, whereas patients with progressive supranuclear palsy had delayed and shortened REM sleep. CONCLUSION: Although Gd-PSP is a tauopathy, most patients experience REM sleep behavior disorder. This suggests that the location of neuronal loss or dysfunction in the midbrain, rather than the protein comprising the histologic lesions (synuclein versus tau aggregation), is responsible for suppressing muscle atonia during REM sleep. Subjects with idiopathic REM sleep behavior disorder should avoid eating sour sop.  (+info)

Synthesis of annonaceous acetogenins from muricatacin. (4/25)

Synthetic studies of annonaceous acetogenins starting from (-)-muricatacin (1a) or (+)-muricatacin are described, involving (-)-muricatacin (1a), mono-THF acetogenin, solamin (2), reticulatacin (3), (15R, 16R, 19S, 20S)-cis-solamin (4a) and (15S, 16S, 19R, 20R)-cis-solamin (4b), non-adjacent bis-THF acetogenin, 4-deoxygigantecin (5), and epoxide-bearing acetogenin, (15S, 16R, 19S, 20R)-diepomuricanin (6a).  (+info)

Anthelmintic acetogenin from Annona squamosa L. Seeds. (5/25)

Annona squamosa seeds extracts showed anthelmintic activity against Haemonchus contortus, the main nematode of sheep and goat in Northeastern Brazil. A compound 1 was isolated from ethyl acetate extract and inhibited the egg hatching of H. contortus at 25 mg ml(-1). The structure of 1 was determined as a C37 trihydroxy adjacent bistetrahydrofuran acetogenin based on spectroscopic analysis.  (+info)

Synthesis and antitumor activity of C-9 epimers of the tetrahydrofuran containing acetogenin 4-deoxyannoreticuin. (6/25)

 (+info)

Halogenated terpenes and a C(15)-acetogenin from the marine red alga Laurencia saitoi. (7/25)

 (+info)

Genotoxic and cytotoxic effects produced by acetogenins obtained from Annona cherimolia Mill. (8/25)

In the present study we extracted three isomeric acetogenins (Ace) from the seeds of Annona cherimolia Mill. (Annonaceae) and determined their genotoxic and cytotoxic potential in mice. Our results showed a significant increase in the rate of micronucleated polychromatic erythrocytes induced by Ace with respect to the value for the control group; the effect was less pronounced than that observed with daunorubicin (Dau). To evaluate cytotoxicity, we determined the proportion of polychromatic erythrocytes with respect to the number of normochromatic erythrocytes, and we found an inhibitory effect induced by Ace that was quite similar to that observed with Dau. Besides, by means of the 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide test, we also determined the cytotoxicity of Ace in both a normal fibroblast mouse cell line and in a line derived from human colon cancer. In this assay, the strongest decrease in viability corresponded to the malignant cell line. Our results established for the first time the genotoxic capacity of these compounds in vivo, and confirmed their cytotoxic potential in cultured cells.  (+info)

Acetogenins are a type of compound that are produced by certain plants, particularly those in the family Annonaceae. They are known for their potential medicinal properties, including anti-cancer, anti-malarial, and insecticidal activities. Acetogenins have a complex structure, consisting of a long chain of carbon atoms with various functional groups attached. They work by inhibiting the function of certain enzymes that are necessary for the survival of cancer cells and other target organisms.

"Annona" is a genus of plants in the custard apple family, Annonaceae. It includes several species that produce edible fruit, such as Annona squamosa (sugar-apple or sweetsop), Annona reticulata (custard apple or bullock's heart), and Annona cherimola (cherimoya). These fruits are native to tropical regions of the Americas and have been cultivated for their sweet, aromatic flesh.

In a medical context, "Annona" is not commonly used as a term. However, some research has investigated the potential medicinal properties of compounds found in Annona species. For example, acetogenins found in the seeds and bark of certain Annona species have been studied for their potential anti-cancer, insecticidal, and anti-malarial properties.

It's worth noting that while some research has suggested that these compounds may have therapeutic potential, more studies are needed to confirm their safety and efficacy in humans. Additionally, it's important to note that the seeds and bark of Annona species can be toxic if ingested in large quantities, so they should not be consumed without medical supervision.

Annonaceae is a family of flowering plants, also known as custard apple family. It includes several genera and species of tropical trees and shrubs that are native to the Americas, Africa, Asia, and Australia. The plants in this family are characterized by their large, often fragrant flowers and fleshy fruits. Some of the commercially important crops in this family include cherimoya, soursop, custard apple, and pawpaw. Many species of Annonaceae have also been studied for their potential medicinal properties, including the presence of alkaloids with anticancer and anti-malarial activities.

Furans are not a medical term, but a class of organic compounds that contain a four-membered ring with four atoms, usually carbon and oxygen. They can be found in some foods and have been used in the production of certain industrial chemicals. Some furan derivatives have been identified as potentially toxic or carcinogenic, but the effects of exposure to these substances depend on various factors such as the level and duration of exposure.

In a medical context, furans may be mentioned in relation to environmental exposures, food safety, or occupational health. For example, some studies have suggested that high levels of exposure to certain furan compounds may increase the risk of liver damage or cancer. However, more research is needed to fully understand the potential health effects of these substances.

It's worth noting that furans are not a specific medical condition or diagnosis, but rather a class of chemical compounds with potential health implications. If you have concerns about exposure to furans or other environmental chemicals, it's best to consult with a healthcare professional for personalized advice and recommendations.

"Uvaria" is not a term that has a widely accepted medical definition. It is a genus of flowering plants in the family Annonaceae, commonly known as the custard apple family. Some species of Uvaria are used in traditional medicine in various parts of the world, but there is limited scientific evidence to support their effectiveness or safety.

If you have any specific medical concern related to a plant or substance in the Uvaria genus, I would recommend consulting with a healthcare professional for accurate information and guidance.

Benzethonium is an antimicrobial agent used as a preservative in some pharmaceutical and cosmetic products. It has broad-spectrum activity against gram-positive and gram-negative bacteria, fungi, and viruses. The chemical name for benzethonium chloride is N'-(1-benzyl-4-phenoxypyridinio) decane methosulfate.

Benzethonium chloride is commonly used as a topical antiseptic in products such as skin cleansers, hand sanitizers, and first aid treatments. It works by disrupting the bacterial cell membrane, leading to the death of the microorganism. However, it may not be effective against some spores and highly resistant bacteria.

It is important to note that benzethonium chloride should be used according to the instructions on the product label and should not be ingested or used in the eyes or mucous membranes unless specifically directed by a healthcare professional.

Lactones are not a medical term per se, but they are important in the field of pharmaceuticals and medicinal chemistry. Lactones are cyclic esters derived from hydroxy acids. They can be found naturally in various plants, fruits, and some insects. In medicine, lactones have been used in the synthesis of drugs, including certain antibiotics and antifungal agents. For instance, the penicillin family of antibiotics contains a beta-lactone ring in their structure, which is essential for their antibacterial activity.

I apologize for any confusion, but "Laurencia" is not a commonly used medical term or diagnosis. It is possible that you may be referring to "Laurasia," which is a geological supercontinent that existed during the early Mesozoic Era, but it is not a medical concept. If you have a different context or meaning in mind, please provide more information so I can give a more accurate response.

Electron Transport Complex I, also known as NADH:ubiquinone oxidoreductase, is a large protein complex located in the inner mitochondrial membrane of eukaryotic cells and the cytoplasmic membrane of prokaryotic cells. It is the first complex in the electron transport chain, a series of protein complexes that transfer electrons from NADH to oxygen, driving the synthesis of ATP through chemiosmosis.

Complex I consists of multiple subunits, including a flavin mononucleotide (FMN) cofactor and several iron-sulfur clusters, which facilitate the oxidation of NADH and the reduction of ubiquinone (coenzyme Q). The energy released during this electron transfer process is used to pump protons across the membrane, creating a proton gradient that drives ATP synthesis.

Defects in Complex I can lead to various mitochondrial diseases, including neurological disorders and muscle weakness.

Acetogenins inhibit NADH dehydrogenase, a key enzyme in energy metabolism. Li, N.; Shi, Z.; Tang, Y.; Chen, J.; Li, X. (2008 ... Acetogenins are a class of polyketide natural products found in plants of the family Annonaceae. They are characterized by ... Purified acetogenins and crude extracts of the common North American pawpaw (Asimina triloba) or the soursop (Annona muricata) ... Media related to Acetogenins at Wikimedia Commons (Articles with short description, Short description matches Wikidata, Commons ...
Several bioactive molecules known as acetogenins have been isolated from its bark including: bullatacin, which has pesticidal ... Gu, Zhe-Ming; Zhao, Geng-Xian; Oberlies, Nicholas H.; Zeng, Lu; McLaughlin, Jerry L. (1995). "Annonaceous Acetogenins". ... a novel bioactive acetogenin from Annona bullata (Annonaceae)". Tetrahedron. 45 (22): 6941-6948. doi:10.1016/S0040-4020(01) ... "New cytotoxic annonaceous acetogenins: Bullatanocin and cis- and trans-Bullatanocinone, from Annona bullata (Annonaceae)". ...
Fang, Xin-Ping; Rieser, Matthew J.; Gu, Zhe-Ming; Zhao, Geng-Xian; McLaughlin, Jerry L. (1993). "Annonaceous acetogenins: An ...
Alali, Feras Q.; Rogers, Lingling; Zhang, Yan; McLaughlin, Jerry L. (1998). "Unusual bioactive annonaceous acetogenins from ...
Terpenes and Acetogenins". American Scientist. 53 (4): 499A-500A. JSTOR 27836252. Singsaas, Eric L. (2000). "Terpenes and the ...
Tchen, T. T. (1965). "Reviewed Work: The Biosynthesis of Steroids, Terpenes & Acetogenins". American Scientist. Research ...
... was the first known example in a class of compounds known as acetogenins. Acetogenins, which are found in plants of ... Zafra-Polo, M. C.; González, M. C.; Estornell, E.; Sahpaz, S.; Cortes, D. (1996). "Acetogenins from Annonaceae, Inhibitors of ...
The bark, leaves, and roots of some species are used in folk medicines.[citation needed] The acetogenin compounds, which occur ... A large number of chemical compounds, including flavonoids, alkaloids, and acetogenins, have been extracted from the seeds and ... Experimental results indicate that acetogenins is responsible for this accumulation. Lancewood (Oxandra lanceolata) is a tough ... 2005-08-02). "Quantification of acetogenins in Annona muricata linked to atypical parkinsonism in guadeloupe". Movement ...
... s are a group of chemical compounds classified as acetogenins. They are found in the extracts of Annona seeds (A. ... and an isolated acetogenin against Helicoverpa armigera". Journal of Pest Science. 90 (2): 701-709. doi:10.1007/s10340-016-0817 ... an Insecticidal Acetogenin of the Pawpaw, Asimina triloba (Annonaceae)". Pesticide Biochemistry and Physiology. Volume 45, ...
It is a member of the class of compounds known as acetogenins. H. Naito; E. Kawahara; K. Maruta; M. Maeda; S. Sasaki (1995). " ... H.-W. Chih; H.-F. Chiu; K.-S. Tang; F.-R. Chang; Y.-C. Wu (2001). "Bullatacin, a potent antitumor annonaceous acetogenin, ... "The First Total Synthesis of (+)-Bullatacin, a Potent Antitumor Annonaceous Acetogenin, and (+)-(15,24)-bis-epi-Bullatacin". ... Two Highly Potent Bioactive Acetogenins from Annona bullata". Journal of Natural Products. 52 (3): 463-477. doi:10.1021/ ...
Other acetogenins have been isolated from the seeds, bark, and leaves.[citation needed] Annona squamosa is native to the ... Bayer AG has patented the extraction process and molecular identity of the annonaceous acetogenin annonin, as well as its use ... 1990). "Bullatacin, bullatacinone, and squamone, a new bioactive acetogenin, from the bark of Annona squamosa". Journal of ... 2012). "Anti-tumor activity of Annona squamosa seeds extract containing annonaceous acetogenin compounds". Journal of ...
He published his findings on the Annonaceous acetogenins in peer reviewed journals. These acetogenins have been identified as ... McLaughlin, Jerry L. (2008). "Paw Paw and Cancer: Annonaceous Acetogenins from Discovery to Commercial Products". Journal of ...
Mitregenin, an acetogenin, has been isolated from its leaves and twigs. Several members of the acetogenin family of compounds ... Zhang, Qiang; Di, Ying-Tong; He, Hong-Ping; Li, Shun-Lin; Hao, Xiao-Jiang (2010). "Mitregenin, a New Annonaceous Acetogenin ...
... is an acetogenin found in Uvaria chamae. (+)-Chamuvarinin was synthesized in 2010 by a research group from the ... Fall, D; Duval, RA; Gleye, C; Laurens, A; Hocquemiller, R (2004). "Chamuvarinin, an acetogenin bearing a tetrahydropyran ring ...
Bioactive molecules isolated from its bark, including acetogenins have been reported to have cytotoxic properties in tests with ... Wongsa, Nikhom; Kanokmedhakul, Somdej; Kanokmedhakul, Kwanjai (2011). "Cananginones A-I, linear acetogenins from the stem bark ...
Due to the presence of acetogenins, the leaves, twigs, and bark of pawpaw trees can be used to make an organic insecticide. The ... Pawpaw defends against herbivory by producing strong-smelling natural toxins known as acetogenins. Pawpaw leaves, twigs, and ... Phytochemical extracts of the bark, leaves, twigs, and seeds contain acetogenins, including the neurotoxin annonacin, as well ... Chemicals consumed by the caterpillars confer protection throughout the butterflies' lives, as trace amounts of acetogenins ...
Like other acetogenins, it is a mitochondrial complex I (NADH-dehydrogenase) inhibitor. As NADH-dehydrogenase is responsible ... It is a member of the class of compounds known as acetogenins. Annonacin-containing fruit products are regularly consumed ... "Determination of Neurotoxic Acetogenins in Pawpaw (Asimina triloba) Fruit by LC-HRMS". Journal of Agricultural and Food ... "Quantification of acetogenins in Annona muricata linked to atypical Parkinsonism in Guadeloupe". Movement Disorders. 20 (12): ...
"C15 acetogenins from the Laurencia complex: 50 years of research - an overview". Revista Brasileira de Farmacognosia. 25 (6): ...
Tantithanaporn, S.; Wattanapiromsakul, C.; Itharat, A.; Keawpradub, N. (2011). "Cytotoxic activity of acetogenins and styryl ...
... is a cytotoxic acetogenin derivate with the molecular formula C35H62O7 which has been isolated from the bark of the ... "Acetogenins as Selective Inhibitors of the Human Ovarian 1A9 Tumor Cell Line". Journal of Medicinal Chemistry. 46 (15): 3185- ... Two novel cytotoxic bis-tetrahydro-furanic γ-lactone acetogenins from Annona cherimolia". Tetrahedron. 47 (38): 8195-8202. doi: ...
Like other members of the family Annonaceae, the entire plant contains small amounts of neurotoxic acetogenins, such as ... December 2005). "Quantification of acetogenins in Annona muricata linked to atypical parkinsonism in guadeloupe". Mov. Disord. ...
Isolated Acetogenins and Biological Activities". International Journal of Molecular Sciences. 16 (7): 15625-15658. doi:10.3390/ ...
The leaves, twigs, and bark of the common pawpaw tree contain natural insecticides known as acetogenins. Larvae of the zebra ...
The tetrahydrofuran ring is found in diverse natural products including lignans, acetogenins, and polyketide natural products. ...
... a new acetogenin inhibitor of mitochondrial electron transport from Xylopia emarginata Mart., Annonaceae". Revista Brasileira ...
November 2016). "Characterization of the Annonaceous acetogenin, annonacinone, a natural product inhibitor of plasminogen ...
Rolliniastatin-2, an acetogenin, is the first complex I inhibitor found that does not share the same binding site as rotenone. ... Acetogenins from Annonaceae are even more potent inhibitors of complex I. They cross-link to the ND2 subunit, which suggests ... Degli Esposti M, Ghelli A, Ratta M, Cortes D, Estornell E (July 1994). "Natural substances (acetogenins) from the family ... an acetogenin found in Asimina triloba fruit) is the most potent known inhibitor of NADH dehydrogenase (ubiquinone) (IC50=1.2 ...
Other acetogenins have been discovered with anti-malarial and anti-tumor properties, and some even inhibit HIV replication in ... The first acetogenin discovered was uvaricin, which has anti-leukemic properties when used in living organisms. ... Several members of the family Annonaceae are also under investigation for uses of a group of chemicals called acetogenins. ...
The compound annonacin and dozens of other acetogenins contained in the seeds and fruit of some members of Annonaceae such as ... Several annonaceous species have been found to contain acetogenins, a class of natural compounds with a wide variety of ... Esposti, M Degli; A Ghelli; M Ratta; D Cortes; E Estornell (1994-07-01). "Natural substances (acetogenins) from the family ...
Bioactive compounds extracted from its bark, including acetogenins, have been reported to be cytotoxic in tests with cultured ...
Acetogenins inhibit NADH dehydrogenase, a key enzyme in energy metabolism. Li, N.; Shi, Z.; Tang, Y.; Chen, J.; Li, X. (2008 ... Acetogenins are a class of polyketide natural products found in plants of the family Annonaceae. They are characterized by ... Purified acetogenins and crude extracts of the common North American pawpaw (Asimina triloba) or the soursop (Annona muricata) ... Media related to Acetogenins at Wikimedia Commons (Articles with short description, Short description matches Wikidata, Commons ...
US-5955497-A chemical patent summary.
Hoye TR, Tan L. Total synthesis of the potent antitumor, bis-tetrahydrofuranyl annonaceous acetogenins (+)-asimicin and (+)- ... Hoye, T. R., & Tan, L. (1995). Total synthesis of the potent antitumor, bis-tetrahydrofuranyl annonaceous acetogenins (+)- ... Hoye, TR & Tan, L 1995, Total synthesis of the potent antitumor, bis-tetrahydrofuranyl annonaceous acetogenins (+)-asimicin ... Total synthesis of the potent antitumor, bis-tetrahydrofuranyl annonaceous acetogenins (+)-asimicin and (+)-bullatacin. / Hoye ...
Finally, the bioactivity of a newly-registered acetogenin-based (Anosom® 1 EC) formulation was investigated, both separately ... the bioguided fractionation using different chromatographic techniques which led to isolation of acetogenin rolliniastatin-1 ...
Annonaceous acetogenin mimic AA005 reportedly inhibits mammalian mitochondrial NADH-ubiquinone reductase (Complex I) and ... Annonaceous acetogenins are a family of natural products with antitumor activities. ... Annonaceous acetogenins are a family of natural products with antitumor activities. Annonaceous acetogenin mimic AA005 ... A) Chemical structures of annonaceous acetogenin mimic AA005. (B-E) Adherent cells of SW620 (B) and BT549 (C), leukemic cells ...
Biologically Active Aliphatic Acetogenins from Specialized Idioblast Oil Cells. Journal: Current Organic Chemistry. Volume: 4 ...
The studies concentrate on the antitumor properties and selective toxicity of annonaceous acetogenins. In 1997, the Purdue team ...
Graviola leaves contain acetogenins, which are active constituents that can support healthy cell growth and function.* Other ... Cancer-fighting properties* - Some preliminary studies suggest that acetogenins found in graviola may help to fight cancer ...
Graviola leaves contain acetogenins, which are active constituents that can support healthy cell growth and function.* Other ... Cancer-fighting properties* - Some preliminary studies suggest that acetogenins found in graviola may help to fight cancer ...
... acetogenins, induce HepG2 cell death through the induction of the complete apoptotic mitochondrial pathway. J. Bioenerg. ...
Muricoreacin and murihexocin C, mono-tetrahydrofuran acetogenins, from the leaves of Annona muricata. Phytochemistry. 1998 Sep; ... New cytotoxic monotetrahydrofuran annonaceous acetogenins from Annona muricata. J Nat Prod. 2002 Apr;65(4):470-5. PMID: ... 6. Oberlies NH, Chang CJ, McLaughlin JL (1997) Structure-activity relationships of diverse Annonaceous acetogenins against ... Two new cytotoxic monotetrahydrofuran Annonaceous acetogenins, annomuricins A and B, from the leaves of Annona muricata. J Nat ...
Antitumor potential of an acetogenin isolated from the seed extracts of Annona squamosa Linn. ...
The authors results in applying these simple methods in the discovery of Annonaceous acetogenins will be presented to ...
The smell is due to a mixture of chemicals, and among these are the acetogenins. This group of chemicals is commonly produced ... In fact, the zebra swallowtail actually sequesters the acetogenins in its body, rendering it toxic to animals that would ...
Soursop (Annona muricata): The plant has a strong antibiotic power due to its acetogenin content, especially in the leaves and ...
More recent scientific studies suggest that acetogenins, the active constituents of graviola, can support healthy cell growth ...
Computational binding affinity and molecular dynamic characterization of annonaceous acetogenins at nucleotide binding domain ( ...
Research has shown that it is antimalarial, uterine stimulant, anticrustacean, antiparasitic, cytotoxic (acetogenins), cardiac ...
Keywords: Acetogenins; Annonamine; AutoDock Vina; Graviola; HeLa cell line; Kaempferol; PC3 cell line; R programming ... It has a wide potent anticancerous agents coined as Acetogenins which play a key role towards many varieties of cancer, ... Acetogenins are potent inhibitors of NADH oxidase of the plasma membranes of cancer cells. Potent leads were taken for the ...
Multiple research studies have discovered beneficial acetogenins in the Graviola plant. Graviola also supports the bodys ...
Acetogenins from the stems of Uvaria micrantha showing antiproliferative effects on HepG2 liver cancer cells. Thongnest S, ... Acetogenins from the stems of Uvaria micrantha showing antiproliferative effects on HepG2 liver cancer cells. Thongnest S, ...
... acetogenins (especially bullatacin and bullatacinone); a camptothecin (including the synthetic analogue topotecan); bryostatin ...
The acetogenins from the paw paw plant inhibit ATP production in cancer cells, depriving them of the energy they need to ...
What is factual and proven through scientific study is that the soursop, with its annonaceous acetogenins is more effective in ...
Acetogenins Acetogenins, Annonaceous use Acetogenins Acetohexamide Acetohydroxy Acid Isomeroreductase use Ketol-Acid ...
IN-VITRO; PATHOGENICITY; ANTIPROTOZOAL; ACETOGENINS; POLYSTYRENE; KERATITIS; ADHESION. categoria. Multidisciplinary Sciences. ...
... acetogenins. 73 shop Managing Sea Cucumber Fisheries With an Ecosystem Approach (Fao Fisheries and Aquaculture Technical;( f) ...
  • Hoye, TR & Tan, L 1995, ' Total synthesis of the potent antitumor, bis-tetrahydrofuranyl annonaceous acetogenins (+)-asimicin and (+)-bullatacin ', Tetrahedron Letters , vol. 36, no. 12, pp. 1981-1984. (umn.edu)
  • Annonaceous acetogenins are a family of natural products with antitumor activities. (biomedcentral.com)
  • Annonaceous acetogenin mimic AA005 reportedly inhibits mammalian mitochondrial NADH-ubiquinone reductase (Complex I) and induces gastric cancer cell death. (biomedcentral.com)
  • The studies concentrate on the antitumor properties and selective toxicity of annonaceous acetogenins. (pearltrees.com)
  • New cytotoxic monotetrahydrofuran annonaceous acetogenins from Annona muricata. (vitanatural.net)
  • 6. Oberlies NH, Chang CJ, McLaughlin JL (1997) Structure-activity relationships of diverse Annonaceous acetogenins against multidrug resistant human mammary adenocarcinoma (MCF-7/Adr) cells. (vitanatural.net)
  • What is factual and proven through scientific study is that the soursop, with its annonaceous acetogenins is more effective in targeting the cells that cancer patients want to target ie the cancer cells. (stackexchange.com)
  • Identification of Annonaceous Acetogenins and Alkaloids from the Leaves, Pulp, and Seeds of Annona atemoya . (bvsalud.org)
  • More recent scientific studies suggest that acetogenins, the active constituents of graviola, can support healthy cell growth and function. (allstarhealth.com)
  • Multiple research studies have discovered beneficial acetogenins in the Graviola plant. (raintree.com)
  • Graviola leaf powder consists of a specialized substance named as acetogenins. (moringaforwholesale.com)
  • These acetogenins are the substance, which helps the Graviola to perform the anti-cancer function of them. (moringaforwholesale.com)
  • The acetogenins produced from the Graviola leaf powder, helps you in the treatment of more than one type of cancer, which includes pancreatic cancer, breast cancer, prostate cancer, liver cancer, lung cancer and lymphomas. (moringaforwholesale.com)
  • However, the acetogenins produced or extracted from the Graviola leaf powder , easily replaces the need for the other potent anti-cancer treatment. (moringaforwholesale.com)
  • Source of acetogenins anti-cancer, graviola in capsules, powder and infusions. (linkorado.com)
  • It's particularly rich in alkaloids, phenols, and acetogenins. (gaiaverso.org)
  • Phenols, alkaloids and acetogenins are the most important and effective compounds. (asianjab.com)
  • Purified acetogenins and crude extracts of the common North American pawpaw (Asimina triloba) or the soursop (Annona muricata) remain under laboratory studies. (wikipedia.org)
  • Pure Soursop Leaf Annona muricata Extract must have Acetogenins! (bionutriciaextract.com)
  • Without Acetogenins, it's not Soursop Leaf Annona muricata! (bionutriciaextract.com)
  • It has a wide potent anticancerous agents coined as Acetogenins which play a key role towards many varieties of cancer, Acetogenins are potent inhibitors of NADH oxidase of the plasma membranes of cancer cells. (ingentaconnect.com)
  • Acetogenins inhibit NADH dehydrogenase, a key enzyme in energy metabolism. (wikipedia.org)
  • The acetogenins from the paw paw plant inhibit ATP production in cancer cells, depriving them of the energy they need to sustain their rapid metabolism. (treelite.com)
  • Oberlies et al (1995) researched the capability of acetogenins to block, or inhibit, the cell growth of tumor cells. (guyabano.com)
  • Examples include: Annonacin Annonins Bullatacin Uvaricin Structurally, acetogenins are a series of C-35/C-37 compounds usually characterized by a long aliphatic chain bearing a terminal methyl-substituted α,β-unsaturated γ-lactone ring, as well as one to three tetrahydrofuran (THF) rings. (wikipedia.org)
  • Plagioneurin B belongs to acetogenin group has well-established class of compounds. (um.edu.my)
  • Two new cytotoxic acetogenins from Annona squamosa . (tramil.net)
  • Natural substances (acetogenins) from the family Annonaceae are powerful inhibitors of mitochondrial NADH dehydrogenase (Complex I)". Biochemical Journal. (wikipedia.org)
  • Acetogenins are a class of polyketide natural products found in plants of the family Annonaceae. (wikipedia.org)
  • Recent Progress on the Total Synthesis of Acetogenins from Annonaceae" (PDF). (wikipedia.org)
  • Acetogenins from Annonaceae. (wikipedia.org)
  • These findings can indicate that acetogenins can selectively block the cell growth of tumor cells, while the healthy cells remain unaffected with minimal toxicity by this compound. (guyabano.com)
  • Its main antioxidants are acetogenins and quercetin. (pharmavita.eu)
  • Furthermore, guyabano is loaded with antioxidants such as acetogenins and flavonoids. (agraryo.com)
  • The smell is due to a mixture of chemicals, and among these are the acetogenins. (cincynature.org)
  • It contains hundreds of chemicals called acetogenins. (whatsdalatest.com)
  • Acetogenins from the stems of Uvaria micrantha showing antiproliferative effects on HepG2 liver cancer cells. (cri.or.th)
  • Acetogenin group has attracted worldwide attention in the past few years due their biological abilities as inhibitors for several types of tumour cells. (um.edu.my)
  • Results showed that the more acetogenins was added with the cancerous cells, the more the cell growth was blocked. (guyabano.com)
  • In addition, the non-cancerous healthy cells were not affected by the acetogenins and the cell growth was not blocked. (guyabano.com)
  • Muricoreacin and murihexocin C, mono-tetrahydrofuran acetogenins, from the leaves of Annona muricata. (vitanatural.net)
  • The plant has a strong antibiotic power due to its acetogenin content, especially in the leaves and seeds. (botanical-online.com)
  • The tree produces these 'acetogenins' in the leaves, stem and bark. (guyabano.com)
  • What everyone would like is to make these acetogenins in big quantities, to help everyone. (guyabano.com)
  • In fact, the zebra swallowtail actually sequesters the acetogenins in its body, rendering it toxic to animals that would otherwise eat it-similar to how monarchs use toxins from milkweeds. (cincynature.org)
  • Acetogenins have been investigated for their biological properties, but are a concern due to neurotoxicity. (wikipedia.org)

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