Adrenal Insufficiency
Addison Disease
Adrenal Glands
Cosyntropin
Adrenal Cortex Function Tests
Hydrocortisone
Adrenocorticotropic Hormone
Adrenal Cortex
Cortodoxone
Adrenal Medulla
DAX-1 Orphan Nuclear Receptor
Adrenal Hyperplasia, Congenital
Hypothalamic Diseases
Cushing Syndrome
Polyendocrinopathies, Autoimmune
Renal Insufficiency
Diagnostic Techniques, Endocrine
Venous Insufficiency
Glucocorticoids
Adrenal Cortex Hormones
Dehydroepiandrosterone
Pituitary-Adrenal System
Adrenoleukodystrophy
Exocrine Pancreatic Insufficiency
46, XY Disorders of Sex Development
Hypothalamo-Hypophyseal System
Hypopituitarism
Etomidate
Placental Insufficiency
Gonadal Dysgenesis, 46,XY
Primary Ovarian Insufficiency
Mineralocorticoids
Steroid 21-Hydroxylase
Shock, Septic
Steroidogenic Factor 1
Pituitary Diseases
Metyrapone
Inappropriate ADH Syndrome
Empty Sella Syndrome
Clobetasol
Receptor, Melanocortin, Type 2
Hormone Replacement Therapy
Central Nervous System Cysts
Pituitary ACTH Hypersecretion
Aldosterone
Thyrotoxicosis
Dehydroepiandrosterone Sulfate
Esophageal Achalasia
Genetic Diseases, X-Linked
Hypogonadism
Pituitary Gland
Corticotropin-Releasing Hormone
Primary hypoadrenocorticism in a dog receiving glucocorticoid supplementation. (1/362)
A 5-year-old, spayed, female husky-Labrador retriever cross was diagnosed with primary hypoadrenocorticism, an uncommon endocrine disorder caused by a deficiency of glucocorticoid and mineralocorticoid hormones. Subtle clinical signs and previous treatment with exogenous glucocorticoid drugs required an adrenocorticotropic hormone stimulation test to confirm the diagnosis. (+info)Tests of adrenal insufficiency. (2/362)
AIM: In suspected adrenal insufficiency, the ideal test for assessing the hypothalamo-pituitary-adrenal axis is controversial. Therefore, three tests were compared in patients presenting with symptoms suggestive of adrenal insufficiency. METHOD: Responses to the standard short Synacthen test (SSST), the low dose Synacthen test (LDST), and the 08:00 hour serum cortisol concentration were measured in 32 patients. A normal response to the synacthen test was defined as a peak serum cortisol of >/= 500 nmol/l and/or incremental concentration of >/= 200 nmol/l. The sensitivity and specificity of the 08:00 hour serum cortisol concentration compared with other tests was calculated. RESULTS: Three patients had neither an adequate peak nor increment after the SSST and LDST. All had a serum 08:00 hour cortisol concentration of < 200 nmol/l. Eight patients had abnormal responses by both criteria to the LDST but had normal responses to the SSST. Three reported amelioration of their symptoms on hydrocortisone replacement. Twenty one patients had a normal response to both tests (of these, 14 achieved adequate peak and increment after both tests and seven did not have an adequate peak after the LDST but had a normal increment). The lowest 08:00 hour serum cortisol concentration above which patients achieved normal responses to both the LDST and SSST was 500 nmol/l. At this cut off value (compared with the LDST), the serum 08:00 hour cortisol concentration had a sensitivity of 100% but specificity was only 33%. CONCLUSION: The LDST revealed mild degrees of adrenal insufficiency not detected by the SSST. The value of a single 08:00 hour serum cortisol concentration is limited. (+info)Adrenal insufficiency in septic shock. (3/362)
BACKGROUND: Functional adrenal insufficiency has been documented in critically ill adults. OBJECTIVE: To document the incidence of adrenal insufficiency in children with septic shock, and to evaluate its effect on catecholamine requirements, duration of intensive care, and mortality. SETTING: Sixteen-bed paediatric intensive care unit in a university hospital. METHODS: Thirty three children with septic shock were enrolled. Adrenal function was assessed by the maximum cortisol response after synthetic adrenocorticotropin stimulation (short Synacthen test). Insufficiency was defined as a post-Synacthen cortisol increment < 200 nmol/l. RESULTS: Overall mortality was 33%. The incidence of adrenal insufficiency was 52% and children with adrenal insufficiency were significantly older and tended to have higher paediatric risk of mortality scores. They also required higher dose vasopressors for haemodynamic stability. In the survivor group, those with adrenal insufficiency needed a longer period of inotropic support than those with normal function (median, 3 v 2 days), but there was no significant difference in duration of ventilation (median, 4 days for each group) or length of stay (median, 5 v 4 days). Mortality was not significantly greater in children with adrenal insufficiency than in those with adequate adrenal function (6 of 17 v 5 of 16, respectively). CONCLUSION: Adrenal insufficiency is common in children with septic shock. It is associated with an increased vasopressor requirement and duration of shock. (+info)Hypercalcemia in an euthyroid patient with secondary hypoadrenalism and diabetes insipidus due to hypothalamic tumor. (4/362)
A 20-year-old Japanese man with a hypothalamic tumor (most likely germ-cell tumor) which caused secondary hypoadrenalism, hypogonadism and diabetes insipidus developed hypercalcemia and acute renal failure. The serum levels of intact PTH (iPTH), PTH-related protein (PTH-rP), 1,25-dihydroxy vitamin D (1,25- (OH)2 D), ACTH, cortisol, gonadotropins and testosterone were decreased, but his serum levels of triiodothyronine (T3) and thyroxine (T4) were within the normal range at admission, with depressed TSH and slightly increased thyroglobulin. The hypercalcemia was refractory to extensive hydration and calcitonin, but was ameliorated by pamidronate. After irradiation of the hypothalamic tumor, panhypopituitarism gradually developed. The patient has been normocalcemic for the last 2 years and is doing well under replacement therapy with glucocorticoid, L-thyroxine, methyltestosterone and 1-desamino D arginine vasopressin (dDAVP). As to the mechanism of euthyroidism at admission, transient destructive thyroiditis associated with hypopituitarism or delayed development of hypothyroidism following the hypoadrenalism was suggested. This is the first reported case of hypercalcemia in secondary hypoadrenalism due to hypothalamic tumor. Hypercalcemia was most likely induced by increased bone resorption, which was probably elicited by the combined effects of deficient glucocorticoid and sufficient thyroid hormones in addition to hypovolemia and reduced renal calcium excretion. Furthermore, severe dehydration due to diabetes insipidus and disturbance of thirst sensation caused by the hypothalamic tumor aggravated the hypercalcemia, leading to acute renal failure. (+info)Severe hyponatremia caused by hypothalamic adrenal insufficiency. (5/362)
A 60-year-old woman was admitted with severe hyponatremia. Basal values of adrenocorticotropic hormone (ACTH), thyroid hormone and cortisol were normal on admission. Impairment of water diuresis was observed by water loading test. Initially, we diagnosed her condition as the syndrome of inappropriate secretion of antidiuretic hormone (SIADH). By provocation test, we finally confirmed that the hyponatremia was caused by hypothalamic adrenal insufficiency. The basal values of ACTH and cortisol might not be sufficient to exclude the possibility of adrenal insufficiency. Therefore, it is necessary to evaluate adrenal function by provocation test or to re-evaluate it after recovery from hyponatremia. (+info)A case of primary bilateral adrenal lymphoma with partial adrenal insufficiency. (6/362)
Unilateral or bilateral non-Hodgkin's lymphomas arising primarily in the adrenal glands are extremely rare. These lymphomas are usually present with large, bilateral adrenal masses with or without lymphadenopathy, and may be accompanied by adrenal insufficiency in some cases. A review of the literature indicates that patients with primary lymphoma of the adrenal glands usually do not have disease elsewhere, and if present, it is frequently extranodal. We report here an unusual case of primary bilateral adrenal lymphoma with partial adrenal insufficiency. (+info)The 4A syndrome association with osteoporosis. (7/362)
4A syndrome is characterised by adrenocortical insufficiency, achalasia, alacrima, autonomic and other neurological abnormalities. We report an 18-year-old boy with 4 A syndrome and having all classical features of the disease including sensorimotor neuropathy. In addition, the patient had low aldosterone levels and signs of osteoporosis, which apparently developed without glucocorticoid replacement therapy. Although it is speculated that the lack of local growth factors, nutritional deficiency secondary to achalasia or receptor abnormalities regarding bone metabolism contribute to osteoporosis, its etiopathogenesis still needs to be clarified. (+info)Dehydroepiandrosterone replacement in women with adrenal insufficiency. (8/362)
BACKGROUND: The physiologic role of dehydroepiandrosterone in humans is still unclear. Adrenal insufficiency leads to a deficiency of dehydroepiandrosterone; we therefore, investigated the effects of dehydroepiandrosterone replacement, in patients with adrenal insufficiency. METHODS: In a double-blind study, 24 women with adrenal insufficiency received in random order 50 mg of dehydroepiandrosterone orally each morning for four months and placebo daily for four months, with a one-month washout period. We measured serum steroid hormones, insulin-like growth factor I, lipids, and sex hormone-binding globulin, and we evaluated well-being and sexuality with the use of validated psychological questionnaires and visual-analogue scales, respectively. The women were assessed before treatment, after one and four months of treatment with dehydroepiandrosterone, after one and four months of placebo, and one month after the end of the second treatment period. RESULTS: Treatment with dehydroepiandrosterone raised the initially low serum concentrations of dehydroepiandrosterone, dehydroepiandrosterone sulfate, androstenedione, and testosterone into the normal range; serum concentrations of sex hormone-binding globulin, total cholesterol, and high-density lipoprotein cholesterol decreased significantly. Dehydroepiandrosterone significantly improved overall well-being as well as scores for depression and anxiety. For the global severity index, the mean (+/-SD) change from base line was -0.18+/-0.29 after four months of dehydroepiandrosterone therapy, as compared with 0.03+/-0.29 after four months of placebo (P=0.02). As compared with placebo, dehydroepiandrosterone significantly increased the frequency of sexual thoughts (P=0.006), sexual interest (P=0.002), and satisfaction with both mental and physical aspects of sexuality (P=0.009 and P=0.02, respectively). CONCLUSIONS: Dehydroepiandrosterone improves well-being and sexuality in women with adrenal insufficiency. (+info)Adrenal insufficiency is a condition in which the adrenal glands do not produce adequate amounts of certain hormones, primarily cortisol and aldosterone. Cortisol helps regulate metabolism, respond to stress, and suppress inflammation, while aldosterone helps regulate sodium and potassium levels in the body to maintain blood pressure.
Primary adrenal insufficiency, also known as Addison's disease, occurs when there is damage to the adrenal glands themselves, often due to autoimmune disorders, infections, or certain medications. Secondary adrenal insufficiency occurs when the pituitary gland fails to produce enough adrenocorticotropic hormone (ACTH), which stimulates the adrenal glands to produce cortisol.
Symptoms of adrenal insufficiency may include fatigue, weakness, weight loss, decreased appetite, nausea, vomiting, diarrhea, abdominal pain, low blood pressure, dizziness, and darkening of the skin. Treatment typically involves replacing the missing hormones with medications taken orally or by injection.
Addison disease, also known as primary adrenal insufficiency or hypocortisolism, is a rare endocrine disorder characterized by the dysfunction and underproduction of hormones produced by the adrenal glands, specifically cortisol and aldosterone. The adrenal glands are located on top of the kidneys and play a crucial role in regulating various bodily functions such as metabolism, blood pressure, stress response, and immune system function.
The primary cause of Addison disease is the destruction of more than 90% of the adrenal cortex, which is the outer layer of the adrenal glands responsible for hormone production. This damage can be due to an autoimmune disorder where the body's immune system mistakenly attacks and destroys the adrenal gland tissue, infections such as tuberculosis or HIV, cancer, genetic disorders, or certain medications.
The symptoms of Addison disease often develop gradually and may include fatigue, weakness, weight loss, decreased appetite, low blood pressure, darkening of the skin, and mood changes. In some cases, an acute crisis known as acute adrenal insufficiency or Addisonian crisis can occur, which is a medical emergency characterized by sudden and severe symptoms such as extreme weakness, confusion, dehydration, vomiting, diarrhea, low blood sugar, and coma.
Diagnosis of Addison disease typically involves blood tests to measure hormone levels, imaging studies such as CT scans or MRIs to assess the adrenal glands' size and structure, and stimulation tests to evaluate the adrenal glands' function. Treatment usually involves replacing the missing hormones with medications such as hydrocortisone, fludrocortisone, and sometimes mineralocorticoids. With proper treatment and management, individuals with Addison disease can lead normal and productive lives.
The adrenal glands are a pair of endocrine glands that are located on top of the kidneys. Each gland has two parts: the outer cortex and the inner medulla. The adrenal cortex produces hormones such as cortisol, aldosterone, and androgens, which regulate metabolism, blood pressure, and other vital functions. The adrenal medulla produces catecholamines, including epinephrine (adrenaline) and norepinephrine (noradrenaline), which help the body respond to stress by increasing heart rate, blood pressure, and alertness.
Cosyntropin is a synthetic form of adrenocorticotropic hormone (ACTH) that is used in medical testing to assess the function of the adrenal glands. ACTH is a hormone produced and released by the pituitary gland that stimulates the production and release of cortisol, a steroid hormone produced by the adrenal glands.
Cosyntropin is typically administered as an injection, and its effects on cortisol production are measured through blood tests taken at various time points after administration. This test, known as a cosyntropin stimulation test or ACTH stimulation test, can help diagnose conditions that affect the adrenal glands, such as Addison's disease or adrenal insufficiency.
It is important to note that while cosyntropin is a synthetic form of ACTH, it is not identical to the natural hormone and may have slightly different effects on the body. Therefore, it should only be used under the supervision of a healthcare professional.
Adrenal cortex function tests are a group of diagnostic tests that evaluate the proper functioning of the adrenal cortex, which is the outer layer of the adrenal glands. These glands are located on top of each kidney and are responsible for producing several essential hormones. The adrenal cortex produces hormones such as cortisol, aldosterone, and androgens.
There are several types of adrenal cortex function tests, including:
1. Cortisol testing: This test measures the levels of cortisol in the blood or urine to determine if the adrenal glands are producing adequate amounts of this hormone. Cortisol helps regulate metabolism, immune response, and stress response.
2. ACTH (adrenocorticotropic hormone) stimulation test: This test measures the adrenal gland's response to ACTH, a hormone produced by the pituitary gland that stimulates the adrenal glands to produce cortisol. The test involves administering synthetic ACTH and measuring cortisol levels before and after administration.
3. Aldosterone testing: This test measures the levels of aldosterone in the blood or urine to determine if the adrenal glands are producing adequate amounts of this hormone. Aldosterone helps regulate electrolyte balance and blood pressure.
4. Dexamethasone suppression test: This test involves administering dexamethasone, a synthetic corticosteroid, to suppress cortisol production. The test measures cortisol levels before and after administration to determine if the adrenal glands are overproducing cortisol.
5. Androgen testing: This test measures the levels of androgens, such as testosterone and dehydroepiandrosterone (DHEA), in the blood or urine to determine if the adrenal glands are producing excessive amounts of these hormones.
Abnormal results from adrenal cortex function tests may indicate conditions such as Addison's disease, Cushing's syndrome, congenital adrenal hyperplasia, and pheochromocytoma.
Adrenal gland diseases refer to a group of medical conditions that affect the function or structure of the adrenal glands. The adrenal glands are small, triangular-shaped glands located on top of each kidney. They are responsible for producing several essential hormones, including cortisol, aldosterone, and adrenaline (epinephrine).
There are various types of adrenal gland diseases, some of which include:
1. Adrenal Insufficiency: A condition where the adrenal glands do not produce enough hormones, particularly cortisol and aldosterone. This can lead to symptoms such as fatigue, weight loss, low blood pressure, and skin hyperpigmentation.
2. Cushing's Syndrome: A condition characterized by an excess of cortisol in the body. It can be caused by a tumor in the pituitary gland or adrenal glands, or it can result from long-term use of steroid medications.
3. Adrenal Cancer: A rare type of cancer that affects the adrenal glands. Symptoms may include abdominal pain, weight loss, and high blood pressure.
4. Pheochromocytoma: A tumor that develops in the adrenal glands and causes an overproduction of adrenaline (epinephrine) and noradrenaline (norepinephrine). Symptoms may include high blood pressure, headaches, sweating, and anxiety.
5. Adrenal Hemorrhage: A condition where bleeding occurs in the adrenal glands, often as a result of severe trauma or infection. This can lead to adrenal insufficiency and other complications.
6. Congenital Adrenal Hyperplasia: An inherited disorder that affects the production of cortisol and other hormones in the adrenal glands. Symptoms may include ambiguous genitalia, precocious puberty, and short stature.
Treatment for adrenal gland diseases varies depending on the specific condition and its severity. Treatment options may include medication, surgery, or radiation therapy.
Hydrocortisone is a synthetic glucocorticoid, which is a class of steroid hormones. It is identical to the naturally occurring cortisol, a hormone produced by the adrenal gland that helps regulate metabolism and helps your body respond to stress. Hydrocortisone has anti-inflammatory effects and is used to treat various inflammatory conditions such as allergies, skin disorders, and autoimmune diseases. It works by suppressing the immune system's response to reduce swelling, redness, itching, and other symptoms caused by inflammation.
Hydrocortisone is available in different forms, including oral tablets, topical creams, lotions, gels, and ointments, as well as injectable solutions. The specific use and dosage depend on the condition being treated and the individual patient's medical history and current health status.
As with any medication, hydrocortisone can have side effects, especially when used in high doses or for extended periods. Common side effects include increased appetite, weight gain, mood changes, insomnia, and skin thinning. Long-term use of hydrocortisone may also increase the risk of developing osteoporosis, diabetes, cataracts, and other health problems. Therefore, it is essential to follow your healthcare provider's instructions carefully when using this medication.
Adrenocorticotropic Hormone (ACTH) is a hormone produced and released by the anterior pituitary gland, a small endocrine gland located at the base of the brain. ACTH plays a crucial role in the regulation of the body's stress response and has significant effects on various physiological processes.
The primary function of ACTH is to stimulate the adrenal glands, which are triangular-shaped glands situated on top of the kidneys. The adrenal glands consist of two parts: the outer cortex and the inner medulla. ACTH specifically targets the adrenal cortex, where it binds to specific receptors and initiates a series of biochemical reactions leading to the production and release of steroid hormones, primarily cortisol (a glucocorticoid) and aldosterone (a mineralocorticoid).
Cortisol is involved in various metabolic processes, such as regulating blood sugar levels, modulating the immune response, and helping the body respond to stress. Aldosterone plays a vital role in maintaining electrolyte and fluid balance by promoting sodium reabsorption and potassium excretion in the kidneys.
ACTH release is controlled by the hypothalamus, another part of the brain, which produces corticotropin-releasing hormone (CRH). CRH stimulates the anterior pituitary gland to secrete ACTH, which in turn triggers cortisol production in the adrenal glands. This complex feedback system helps maintain homeostasis and ensures that appropriate amounts of cortisol are released in response to various physiological and psychological stressors.
Disorders related to ACTH can lead to hormonal imbalances, resulting in conditions such as Cushing's syndrome (excessive cortisol production) or Addison's disease (insufficient cortisol production). Proper diagnosis and management of these disorders typically involve assessing the function of the hypothalamic-pituitary-adrenal axis and addressing any underlying issues affecting ACTH secretion.
Adrenal gland neoplasms refer to abnormal growths or tumors in the adrenal glands. These glands are located on top of each kidney and are responsible for producing hormones that regulate various bodily functions such as metabolism, blood pressure, and stress response. Adrenal gland neoplasms can be benign (non-cancerous) or malignant (cancerous).
Benign adrenal tumors are called adenomas and are usually small and asymptomatic. However, some adenomas may produce excessive amounts of hormones, leading to symptoms such as high blood pressure, weight gain, and mood changes.
Malignant adrenal tumors are called adrenocortical carcinomas and are rare but aggressive cancers that can spread to other parts of the body. Symptoms of adrenocortical carcinoma may include abdominal pain, weight loss, and hormonal imbalances.
It is important to diagnose and treat adrenal gland neoplasms early to prevent complications and improve outcomes. Diagnostic tests may include imaging studies such as CT scans or MRIs, as well as hormone level testing and biopsy. Treatment options may include surgery, radiation therapy, chemotherapy, or a combination of these approaches.
The adrenal cortex is the outer portion of the adrenal gland, which is located on top of the kidneys. It plays a crucial role in producing hormones that are essential for various bodily functions. The adrenal cortex is divided into three zones:
1. Zona glomerulosa: This outermost zone produces mineralocorticoids, primarily aldosterone. Aldosterone helps regulate sodium and potassium balance and thus influences blood pressure by controlling the amount of fluid in the body.
2. Zona fasciculata: The middle layer is responsible for producing glucocorticoids, with cortisol being the most important one. Cortisol regulates metabolism, helps manage stress responses, and has anti-inflammatory properties. It also plays a role in blood sugar regulation and maintaining the body's response to injury and illness.
3. Zona reticularis: The innermost zone produces androgens, primarily dehydroepiandrosterone (DHEA) and its sulfate form (DHEAS). These androgens are weak compared to those produced by the gonads (ovaries or testes), but they can be converted into more potent androgens or estrogens in peripheral tissues.
Disorders related to the adrenal cortex can lead to hormonal imbalances, affecting various bodily functions. Examples include Addison's disease (insufficient adrenal cortical hormone production) and Cushing's syndrome (excessive glucocorticoid levels).
I am not aware of a medical definition for "Cortodoxone." It is possible that this term is not recognized in the field of medicine as it does not appear to be a commonly used medication, treatment, or diagnostic tool. If you have any more information about where you encountered this term or its potential meaning, I would be happy to try and provide further clarification.
Fludrocortisone is a synthetic corticosteroid hormone, specifically a mineralocorticoid. It is often used to treat conditions associated with low levels of corticosteroids, such as Addison's disease. It works by helping the body retain sodium and lose potassium, which helps to maintain fluid balance and blood pressure.
In medical terms, fludrocortisone is defined as a synthetic mineralocorticoid with glucocorticoid activity used in the treatment of adrenogenital syndrome and Addison's disease, and as an adjunct in the treatment of rheumatoid arthritis. It is also used to treat orthostatic hypotension by helping the body retain sodium and water, thereby increasing blood volume and blood pressure.
It is important to note that fludrocortisone can have significant side effects, particularly if used in high doses or for long periods of time. These can include fluid retention, high blood pressure, increased risk of infection, and slowed growth in children. As with any medication, it should be used under the close supervision of a healthcare provider.
The adrenal medulla is the inner part of the adrenal gland, which is located on top of the kidneys. It is responsible for producing and releasing hormones such as epinephrine (also known as adrenaline) and norepinephrine (also known as noradrenaline). These hormones play a crucial role in the body's "fight or flight" response, preparing the body for immediate action in response to stress.
Epinephrine increases heart rate, blood pressure, and respiratory rate, while also increasing blood flow to muscles and decreasing blood flow to the skin and digestive system. Norepinephrine has similar effects but is generally less potent than epinephrine. Together, these hormones help to prepare the body for physical activity and increase alertness and focus.
Disorders of the adrenal medulla can lead to a variety of symptoms, including high blood pressure, rapid heart rate, anxiety, and tremors. Some conditions that affect the adrenal medulla include pheochromocytoma, a tumor that causes excessive production of epinephrine and norepinephrine, and neuroblastoma, a cancerous tumor that arises from immature nerve cells in the adrenal gland.
DAX-1 (Dosage-sensitive sex reversal, adrenal hypoplasia critical region, on chromosome X, gene 1) is a nuclear receptor protein that functions as a transcriptional regulator. It is also known as NR0B1 (Nuclear Receptor Subfamily 0, Group B, Member 1).
DAX-1 plays crucial roles in various developmental processes, including sexual differentiation and adrenal gland development. Mutations in the DAX-1 gene have been associated with X-linked adrenal hypoplasia congenita (AHC), a condition characterized by defective adrenal gland development and primary adrenal insufficiency.
The term "Orphan Nuclear Receptor" refers to a class of nuclear receptors for which no natural ligand has been identified yet. DAX-1 is one such orphan nuclear receptor, as its specific endogenous ligand remains unknown. However, recent studies suggest that steroids and other small molecules might interact with DAX-1 and modulate its activity.
Congenital Adrenal Hyperplasia (CAH) is a group of inherited genetic disorders that affect the adrenal glands, which are triangular-shaped glands located on top of the kidneys. The adrenal glands are responsible for producing several essential hormones, including cortisol, aldosterone, and androgens.
CAH is caused by mutations in genes that code for enzymes involved in the synthesis of these hormones. The most common form of CAH is 21-hydroxylase deficiency, which affects approximately 90% to 95% of all cases. Other less common forms of CAH include 11-beta-hydroxylase deficiency and 3-beta-hydroxysteroid dehydrogenase deficiency.
The severity of the disorder can vary widely, depending on the degree of enzyme deficiency. In severe cases, the lack of cortisol production can lead to life-threatening salt wasting and electrolyte imbalances in newborns. The excess androgens produced due to the enzyme deficiency can also cause virilization, or masculinization, of female fetuses, leading to ambiguous genitalia at birth.
In milder forms of CAH, symptoms may not appear until later in childhood or even adulthood. These may include early puberty, rapid growth followed by premature fusion of the growth plates and short stature, acne, excessive hair growth, irregular menstrual periods, and infertility.
Treatment for CAH typically involves replacing the missing hormones with medications such as hydrocortisone, fludrocortisone, and/or sex hormones. Regular monitoring of hormone levels and careful management of medication doses is essential to prevent complications such as adrenal crisis, growth suppression, and osteoporosis.
In severe cases of CAH, early diagnosis and treatment can help prevent or minimize the risk of serious health problems and improve quality of life. Genetic counseling may also be recommended for affected individuals and their families to discuss the risks of passing on the disorder to future generations.
Hypothalamic diseases refer to conditions that affect the hypothalamus, a small but crucial region of the brain responsible for regulating many vital functions in the body. The hypothalamus helps control:
1. Body temperature
2. Hunger and thirst
3. Sleep cycles
4. Emotions and behavior
5. Release of hormones from the pituitary gland
Hypothalamic diseases can be caused by genetic factors, infections, tumors, trauma, or other conditions that damage the hypothalamus. Some examples of hypothalamic diseases include:
1. Hypothalamic dysfunction syndrome: A condition characterized by various symptoms such as obesity, sleep disturbances, and hormonal imbalances due to hypothalamic damage.
2. Kallmann syndrome: A genetic disorder that affects the development of the hypothalamus and results in a lack of sexual maturation and a decreased sense of smell.
3. Prader-Willi syndrome: A genetic disorder that causes obesity, developmental delays, and hormonal imbalances due to hypothalamic dysfunction.
4. Craniopharyngiomas: Tumors that develop near the pituitary gland and hypothalamus, often causing visual impairment, hormonal imbalances, and growth problems.
5. Infiltrative diseases: Conditions such as sarcoidosis or histiocytosis can infiltrate the hypothalamus, leading to various symptoms related to hormonal imbalances and neurological dysfunction.
6. Traumatic brain injury: Damage to the hypothalamus due to head trauma can result in various hormonal and neurological issues.
7. Infections: Bacterial or viral infections that affect the hypothalamus, such as encephalitis or meningitis, can cause damage and lead to hypothalamic dysfunction.
Treatment for hypothalamic diseases depends on the underlying cause and may involve medications, surgery, hormone replacement therapy, or other interventions to manage symptoms and improve quality of life.
Cushing syndrome is a hormonal disorder that occurs when your body is exposed to high levels of the hormone cortisol for a long time. This can happen due to various reasons such as taking high doses of corticosteroid medications or tumors that produce cortisol or adrenocorticotropic hormone (ACTH).
The symptoms of Cushing syndrome may include:
* Obesity, particularly around the trunk and upper body
* Thinning of the skin, easy bruising, and purple or red stretch marks on the abdomen, thighs, breasts, and arms
* Weakened bones, leading to fractures
* High blood pressure
* High blood sugar
* Mental changes such as depression, anxiety, and irritability
* Increased fatigue and weakness
* Menstrual irregularities in women
* Decreased fertility in men
Cushing syndrome can be diagnosed through various tests, including urine and blood tests to measure cortisol levels, saliva tests, and imaging tests to locate any tumors. Treatment depends on the cause of the condition but may include surgery, radiation therapy, chemotherapy, or adjusting medication dosages.
Adrenalectomy is a surgical procedure in which one or both adrenal glands are removed. The adrenal glands are small, triangular-shaped glands located on top of each kidney that produce hormones such as cortisol, aldosterone, and adrenaline (epinephrine).
There are several reasons why an adrenalectomy may be necessary. For example, the procedure may be performed to treat tumors or growths on the adrenal glands, such as pheochromocytomas, which can cause high blood pressure and other symptoms. Adrenalectomy may also be recommended for patients with Cushing's syndrome, a condition in which the body is exposed to too much cortisol, or for those with adrenal cancer.
During an adrenalectomy, the surgeon makes an incision in the abdomen or back and removes the affected gland or glands. In some cases, laparoscopic surgery may be used, which involves making several small incisions and using specialized instruments to remove the gland. After the procedure, patients may need to take hormone replacement therapy to compensate for the loss of adrenal gland function.
Hyponatremia is a condition characterized by abnormally low sodium levels in the blood, specifically levels less than 135 mEq/L. Sodium is an essential electrolyte that helps regulate water balance in and around your cells and plays a crucial role in nerve and muscle function. Hyponatremia can occur due to various reasons, including certain medical conditions, medications, or excessive water intake leading to dilution of sodium in the body. Symptoms may range from mild, such as nausea, confusion, and headache, to severe, like seizures, coma, or even death in extreme cases. It's essential to seek medical attention if you suspect hyponatremia, as prompt diagnosis and treatment are vital for a favorable outcome.
Polyendocrinopathies, autoimmune refers to a group of disorders that involve malfunction of multiple endocrine glands, caused by the immune system mistakenly attacking and damaging these glands. The endocrine glands are responsible for producing hormones that regulate various functions in the body.
There are several types of autoimmune polyendocrinopathies, including:
1. Autoimmune Polyendocrine Syndrome Type 1 (APS-1): Also known as Autoimmune Polyglandular Syndrome Type 1 or APECED, this is a rare inherited disorder that typically affects multiple endocrine glands and other organs. It is caused by mutations in the autoimmune regulator (AIRE) gene.
2. Autoimmune Polyendocrine Syndrome Type 2 (APS-2): Also known as Schmidt's syndrome, this disorder typically involves the adrenal glands, thyroid gland, and/or insulin-producing cells in the pancreas. It is more common than APS-1 and often affects middle-aged women.
3. Autoimmune Polyendocrine Syndrome Type 3 (APS-3): This disorder involves the presence of autoimmune Addison's disease, with or without other autoimmune disorders such as thyroid disease, type 1 diabetes, or vitiligo.
4. Autoimmune Polyendocrine Syndrome Type 4 (APS-4): This is a catch-all category for individuals who have multiple autoimmune endocrine disorders that do not fit into the other types of APS.
Symptoms of autoimmune polyendocrinopathies can vary widely depending on which glands are affected and the severity of the damage. Treatment typically involves replacing the hormones that are no longer being produced in sufficient quantities, as well as managing any underlying immune system dysfunction.
Renal insufficiency, also known as kidney failure, is a medical condition in which the kidneys are unable to properly filter waste products and excess fluids from the blood. This results in a buildup of these substances in the body, which can cause a variety of symptoms such as weakness, shortness of breath, and fluid retention. Renal insufficiency can be acute, meaning it comes on suddenly, or chronic, meaning it develops over time. It is typically diagnosed through blood tests, urine tests, and imaging studies. Treatment may include medications to control symptoms, dietary changes, and in severe cases, dialysis or a kidney transplant.
Diagnostic techniques in endocrinology are methods used to identify and diagnose various endocrine disorders. These techniques include:
1. Hormone measurements: Measuring the levels of hormones in blood, urine, or saliva can help identify excess or deficiency of specific hormones. This is often done through immunoassays, which use antibodies to detect and quantify hormones.
2. Provocative and suppression tests: These tests involve administering a medication that stimulates or suppresses the release of a particular hormone. Blood samples are taken before and after the medication is given to assess changes in hormone levels. Examples include the glucose tolerance test for diabetes, the ACTH stimulation test for adrenal insufficiency, and the thyroid suppression test for hyperthyroidism.
3. Imaging studies: Various imaging techniques can be used to visualize endocrine glands and identify structural abnormalities such as tumors or nodules. These include X-rays, ultrasound, computed tomography (CT), magnetic resonance imaging (MRI), and nuclear medicine scans using radioactive tracers.
4. Genetic testing: Molecular genetic tests can be used to identify genetic mutations associated with certain endocrine disorders, such as multiple endocrine neoplasia type 1 or 2, or congenital adrenal hyperplasia.
5. Biopsy: In some cases, a small sample of tissue may be removed from an endocrine gland for microscopic examination (biopsy). This can help confirm the presence of cancer or other abnormalities.
6. Functional tests: These tests assess the ability of an endocrine gland to produce and secrete hormones in response to various stimuli. Examples include the glucagon stimulation test for gastrinoma and the calcium infusion test for hyperparathyroidism.
7. Wearable monitoring devices: Continuous glucose monitoring systems (CGMS) are wearable devices that measure interstitial glucose levels continuously over several days, providing valuable information about glycemic control in patients with diabetes.
Venous insufficiency is a medical condition that occurs when the veins, particularly in the legs, have difficulty returning blood back to the heart due to impaired valve function or obstruction in the vein. This results in blood pooling in the veins, leading to symptoms such as varicose veins, swelling, skin changes, and ulcers. Prolonged venous insufficiency can cause chronic pain and affect the quality of life if left untreated.
Glucocorticoids are a class of steroid hormones that are naturally produced in the adrenal gland, or can be synthetically manufactured. They play an essential role in the metabolism of carbohydrates, proteins, and fats, and have significant anti-inflammatory effects. Glucocorticoids suppress immune responses and inflammation by inhibiting the release of inflammatory mediators from various cells, such as mast cells, eosinophils, and lymphocytes. They are frequently used in medical treatment for a wide range of conditions, including allergies, asthma, rheumatoid arthritis, dermatological disorders, and certain cancers. Prolonged use or high doses of glucocorticoids can lead to several side effects, such as weight gain, mood changes, osteoporosis, and increased susceptibility to infections.
The adrenal cortex hormones are a group of steroid hormones produced and released by the outer portion (cortex) of the adrenal glands, which are located on top of each kidney. These hormones play crucial roles in regulating various physiological processes, including:
1. Glucose metabolism: Cortisol helps control blood sugar levels by increasing glucose production in the liver and reducing its uptake in peripheral tissues.
2. Protein and fat metabolism: Cortisol promotes protein breakdown and fatty acid mobilization, providing essential building blocks for energy production during stressful situations.
3. Immune response regulation: Cortisol suppresses immune function to prevent overactivation and potential damage to the body during stress.
4. Cardiovascular function: Aldosterone regulates electrolyte balance and blood pressure by promoting sodium reabsorption and potassium excretion in the kidneys.
5. Sex hormone production: The adrenal cortex produces small amounts of sex hormones, such as androgens and estrogens, which contribute to sexual development and function.
6. Growth and development: Cortisol plays a role in normal growth and development by influencing the activity of growth-promoting hormones like insulin-like growth factor 1 (IGF-1).
The main adrenal cortex hormones include:
1. Glucocorticoids: Cortisol is the primary glucocorticoid, responsible for regulating metabolism and stress response.
2. Mineralocorticoids: Aldosterone is the primary mineralocorticoid, involved in electrolyte balance and blood pressure regulation.
3. Androgens: Dehydroepiandrosterone (DHEA) and its sulfate derivative (DHEAS) are the most abundant adrenal androgens, contributing to sexual development and function.
4. Estrogens: Small amounts of estrogens are produced by the adrenal cortex, mainly in women.
Disorders related to impaired adrenal cortex hormone production or regulation can lead to various clinical manifestations, such as Addison's disease (adrenal insufficiency), Cushing's syndrome (hypercortisolism), and congenital adrenal hyperplasia (CAH).
Dehydroepiandrosterone (DHEA) is a steroid hormone produced by the adrenal glands. It serves as a precursor to other hormones, including androgens such as testosterone and estrogens such as estradiol. DHEA levels typically peak during early adulthood and then gradually decline with age.
DHEA has been studied for its potential effects on various health conditions, including aging, cognitive function, sexual dysfunction, and certain chronic diseases. However, the evidence supporting its use for these purposes is generally limited and inconclusive. As with any supplement or medication, it's important to consult with a healthcare provider before taking DHEA to ensure safety and effectiveness.
The pituitary-adrenal system, also known as the hypothalamic-pituitary-adrenal (HPA) axis, is a complex set of interactions between the hypothalamus, the pituitary gland, and the adrenal glands. This system plays a crucial role in the body's response to stress through the release of hormones that regulate various physiological processes.
The hypothalamus, located within the brain, receives information from the nervous system about the internal and external environment and responds by releasing corticotropin-releasing hormone (CRH) and vasopressin. These hormones then travel to the anterior pituitary gland, where they stimulate the release of adrenocorticotropic hormone (ACTH).
ACTH is transported through the bloodstream to the adrenal glands, which are located on top of the kidneys. The adrenal glands consist of two parts: the outer cortex and the inner medulla. ACTH specifically targets the adrenal cortex, causing it to release cortisol and other glucocorticoids, as well as androgens such as dehydroepiandrosterone (DHEA).
Cortisol has numerous effects on metabolism, immune function, and cardiovascular regulation. It helps regulate blood sugar levels, suppresses the immune system, and aids in the breakdown of fats, proteins, and carbohydrates to provide energy during stressful situations. DHEA can be converted into male and female sex hormones (androgens and estrogens) in various tissues throughout the body.
The pituitary-adrenal system is tightly regulated through negative feedback mechanisms. High levels of cortisol, for example, inhibit the release of CRH and ACTH from the hypothalamus and pituitary gland, respectively, thereby limiting further cortisol production. Dysregulation of this system has been implicated in several medical conditions, including Cushing's syndrome (overproduction of cortisol) and Addison's disease (underproduction of cortisol).
Adrenoleukodystrophy (ADL) is a rare genetic disorder that affects the nervous system and adrenal glands. It is characterized by the accumulation of very long-chain fatty acids (VLCFAs) in the brain, leading to progressive neurological symptoms such as behavioral changes, visual loss, hearing loss, seizures, and difficulties with coordination and movement.
ADL is caused by mutations in the ABCD1 gene, which provides instructions for making a protein involved in the breakdown of VLCFA. Without this protein, VLCFAs accumulate in the brain and adrenal glands, leading to damage and dysfunction.
There are several forms of ADL, including:
* Childhood cerebral ADL: This is the most severe form of the disorder, typically affecting boys between the ages of 4 and 8. It progresses rapidly and can lead to significant neurological impairment within a few years.
* Adrenomyeloneuropathy (AMN): This form of ADL affects both men and women and is characterized by progressive stiffness, weakness, and spasticity in the legs. It typically develops in adulthood and progresses slowly over many years.
* Addison's disease: This is a condition that affects the adrenal glands, leading to hormonal imbalances and symptoms such as fatigue, weight loss, and low blood pressure.
There is no cure for ADL, but treatments can help manage the symptoms and slow down the progression of the disorder. These may include dietary changes, medications to control seizures or hormone levels, and physical therapy. In some cases, stem cell transplantation may be recommended as a treatment option.
Exocrine pancreatic insufficiency (EPI) is a condition characterized by the reduced ability to digest and absorb nutrients due to a lack of digestive enzymes produced by the exocrine glands in the pancreas. These enzymes, including lipases, amylases, and proteases, are necessary for breaking down fats, carbohydrates, and proteins in food during the digestion process.
When EPI occurs, undigested food passes through the gastrointestinal tract, leading to malabsorption of nutrients, which can result in various symptoms such as abdominal pain, bloating, diarrhea, weight loss, and steatorrhea (fatty stools). EPI is often associated with chronic pancreatitis, cystic fibrosis, pancreatic cancer, or other conditions that damage the exocrine glands in the pancreas.
EPI can be diagnosed through various tests, including fecal elastase testing, fecal fat quantification, and imaging studies to assess the structure and function of the pancreas. Treatment typically involves replacing the missing enzymes with oral supplements taken with meals and snacks to improve digestion and absorption of nutrients. In addition, dietary modifications and management of underlying conditions are essential for optimal outcomes.
'46, XY Disorders of Sex Development' (DSD) is a term used to describe conditions in which individuals are born with chromosomes, gonads, or genitals that do not fit typical definitions of male or female. In these cases, the individual has 46 chromosomes, including one X and one Y chromosome (46, XY), which would typically result in the development of male characteristics. However, for various reasons, the sexual differentiation process may be disrupted, leading to atypical development of the internal and/or external sex organs.
There are several possible causes of 46, XY DSD, including genetic mutations, hormonal imbalances, or anatomical abnormalities. These conditions can range from mild to severe in terms of their impact on physical health and sexual function, and they may also have psychological and social implications.
Examples of 46, XY DSD include complete androgen insensitivity syndrome (CAIS), partial androgen insensitivity syndrome (PAIS), and disorders of gonadal development such as Swyer syndrome. Treatment for 46, XY DSD may involve surgical intervention, hormone replacement therapy, and/or psychological support.
The Hypothalamo-Hypophyseal system, also known as the hypothalamic-pituitary system, is a crucial part of the endocrine system that regulates many bodily functions. It consists of two main components: the hypothalamus and the pituitary gland.
The hypothalamus is a region in the brain that receives information from various parts of the body and integrates them to regulate vital functions such as body temperature, hunger, thirst, sleep, and emotional behavior. It also produces and releases neurohormones that control the secretion of hormones from the pituitary gland.
The pituitary gland is a small gland located at the base of the brain, just below the hypothalamus. It consists of two parts: the anterior pituitary (also called adenohypophysis) and the posterior pituitary (also called neurohypophysis). The anterior pituitary produces and releases several hormones that regulate various bodily functions such as growth, metabolism, reproduction, and stress response. The posterior pituitary stores and releases hormones produced by the hypothalamus, including antidiuretic hormone (ADH) and oxytocin.
The hypothalamo-hypophyseal system works together to maintain homeostasis in the body by regulating various physiological processes through hormonal signaling. Dysfunction of this system can lead to several endocrine disorders, such as diabetes insipidus, pituitary tumors, and hypothalamic-pituitary axis disorders.
Hypopituitarism is a medical condition characterized by deficient secretion of one or more hormones produced by the pituitary gland, a small endocrine gland located at the base of the brain. The pituitary gland controls several other endocrine glands in the body, including the thyroid, adrenals, and sex glands (ovaries and testes).
Hypopituitarism can result from damage to the pituitary gland due to various causes such as tumors, surgery, radiation therapy, trauma, or inflammation. In some cases, hypopituitarism may also be caused by a dysfunction of the hypothalamus, a region in the brain that regulates the pituitary gland's function.
The symptoms and signs of hypopituitarism depend on which hormones are deficient and can include fatigue, weakness, decreased appetite, weight loss, low blood pressure, decreased sex drive, infertility, irregular menstrual periods, intolerance to cold, constipation, thinning hair, dry skin, and depression.
Treatment of hypopituitarism typically involves hormone replacement therapy to restore the deficient hormones' normal levels. The type and dosage of hormones used will depend on which hormones are deficient and may require regular monitoring and adjustments over time.
Etomidate is a intravenous anesthetic medication used for the induction of general anesthesia. It provides a rapid and smooth induction with minimal cardiovascular effects, making it a popular choice in patients with hemodynamic instability. Etomidate also has antiseizure properties. However, its use is associated with adrenal suppression, which can lead to complications such as hypotension and impaired stress response. Therefore, its use is generally avoided in critically ill or septic patients.
The medical definition of 'Etomidate' is:
A carboxylated imidazole derivative that is used as an intravenous anesthetic for the induction of general anesthesia. It has a rapid onset of action and minimal cardiovascular effects, making it useful in patients with hemodynamic instability. Etomidate also has antiseizure properties. However, its use is associated with adrenal suppression, which can lead to complications such as hypotension and impaired stress response. Therefore, its use is generally avoided in critically ill or septic patients.
Placental insufficiency is a condition in which the placenta does not provide adequate nutrients and oxygen to the developing fetus. This can occur due to various reasons, such as poor placental development, damage to the placenta, or problems with the blood flow to the placenta. As a result, the fetus may receive less oxygen and nutrients than it needs for proper growth and development, which can lead to a range of complications, including low birth weight, preterm birth, and developmental delays.
The medical definition of placental insufficiency is: "a condition in which the placenta fails to provide adequate support to the developing fetus, resulting in impaired fetal growth and development." This condition can be diagnosed through various tests, such as ultrasound, fetal monitoring, and blood tests, and may require close monitoring and management throughout pregnancy to ensure the best possible outcomes for both the mother and the baby.
Gonadal dysgenesis, 46,XY is a medical condition where the gonads (testes) fail to develop or function properly in an individual with a 46,XY karyotype (a normal male chromosomal composition). This means that the person has one X and one Y chromosome, but their gonads do not develop into fully functional testes. As a result, the person may have ambiguous genitalia or female external genitalia, and they will typically not produce enough or any male hormones. The condition can also be associated with an increased risk of developing germ cell tumors in the dysgenetic gonads.
The severity of gonadal dysgenesis, 46,XY can vary widely, and it may be accompanied by other developmental abnormalities or syndromes. Treatment typically involves surgical removal of the dysgenetic gonads to reduce the risk of tumor development, as well as hormone replacement therapy to support normal sexual development and reproductive function. The underlying cause of gonadal dysgenesis, 46,XY is not always known, but it can be associated with genetic mutations or chromosomal abnormalities.
Primary Ovarian Insufficiency (POI), also known as Premature Ovarian Failure, is a condition characterized by the cessation of ovarian function before the age of 40. This results in decreased estrogen production and loss of fertility. It is often associated with menstrual irregularities or amenorrhea (absence of menstruation). The exact cause can vary, including genetic factors, autoimmune diseases, toxins, and iatrogenic causes such as chemotherapy or radiation therapy.
Mineralocorticoids are a class of steroid hormones that primarily regulate electrolyte and fluid balance in the body. The most important mineralocorticoid is aldosterone, which is produced by the adrenal gland in response to signals from the renin-angiotensin system. Aldosterone acts on the distal tubules and collecting ducts of the nephrons in the kidneys to increase the reabsorption of sodium ions (Na+) and water into the bloodstream, while promoting the excretion of potassium ions (K+) and hydrogen ions (H+) into the urine. This helps maintain blood pressure and volume, as well as ensuring a proper balance of electrolytes in the body. Other mineralocorticoids include cortisol and corticosterone, which have weak mineralocorticoid activity and play a more significant role as glucocorticoids, regulating metabolism and immune response.
Steroid 21-hydroxylase, also known as CYP21A2, is a crucial enzyme involved in the synthesis of steroid hormones in the adrenal gland. Specifically, it catalyzes the conversion of 17-hydroxyprogesterone to 11-deoxycortisol and progesterone to deoxycorticosterone in the glucocorticoid and mineralocorticoid pathways, respectively.
Deficiency or mutations in this enzyme can lead to a group of genetic disorders called congenital adrenal hyperplasia (CAH), which is characterized by impaired cortisol production and disrupted hormonal balance. Depending on the severity of the deficiency, CAH can result in various symptoms such as ambiguous genitalia, precocious puberty, sexual infantilism, infertility, and increased risk of adrenal crisis.
Septic shock is a serious condition that occurs as a complication of an infection that has spread throughout the body. It's characterized by a severe drop in blood pressure and abnormalities in cellular metabolism, which can lead to organ failure and death if not promptly treated.
In septic shock, the immune system overreacts to an infection, releasing an overwhelming amount of inflammatory chemicals into the bloodstream. This leads to widespread inflammation, blood vessel dilation, and leaky blood vessels, which can cause fluid to leak out of the blood vessels and into surrounding tissues. As a result, the heart may not be able to pump enough blood to vital organs, leading to organ failure.
Septic shock is often caused by bacterial infections, but it can also be caused by fungal or viral infections. It's most commonly seen in people with weakened immune systems, such as those who have recently undergone surgery, have chronic medical conditions, or are taking medications that suppress the immune system.
Prompt diagnosis and treatment of septic shock is critical to prevent long-term complications and improve outcomes. Treatment typically involves aggressive antibiotic therapy, intravenous fluids, vasopressors to maintain blood pressure, and supportive care in an intensive care unit (ICU).
Lacrimal apparatus diseases refer to conditions that affect the structure and function of the lacrimal system, which is responsible for producing, storing, and draining tears. The lacrimal apparatus includes the lacrimal glands, lacrimal canaliculi, lacrimal sac, and nasolacrimal duct.
Diseases of the lacrimal apparatus can cause a range of symptoms, including watery eyes, redness, pain, swelling, and discharge. Some common conditions that affect the lacrimal apparatus include:
1. Dry eye syndrome: A condition in which the lacrimal glands do not produce enough tears or the tears are of poor quality, leading to dryness, irritation, and inflammation of the eyes.
2. Dacryocystitis: An infection of the lacrimal sac that can cause pain, swelling, redness, and discharge from the eye.
3. Nasolacrimal duct obstruction: A blockage in the nasolacrimal duct that can cause watery eyes, discharge, and recurrent infections.
4. Epiphora: Excessive tearing or watering of the eyes due to overflow of tears from the eye because of blocked tear ducts or increased production of tears.
5. Canaliculitis: An infection of the lacrimal canaliculi that can cause swelling, redness, and discharge from the eye.
6. Lacrimal gland tumors: Rare tumors that can affect the lacrimal glands and cause symptoms such as pain, swelling, and protrusion of the eyeball.
Treatment for lacrimal apparatus diseases depends on the specific condition and its severity. Treatment options may include medications, surgery, or a combination of both.
Adrenal cortex neoplasms refer to abnormal growths (tumors) in the adrenal gland's outer layer, known as the adrenal cortex. These neoplasms can be benign or malignant (cancerous). Benign tumors are called adrenal adenomas, while cancerous tumors are called adrenocortical carcinomas.
Adrenal cortex neoplasms can produce various hormones, leading to different clinical presentations. For instance, they may cause Cushing's syndrome (characterized by excessive cortisol production), Conn's syndrome (caused by aldosterone excess), or virilization (due to androgen excess). Some tumors may not produce any hormones and are discovered incidentally during imaging studies for unrelated conditions.
The diagnosis of adrenal cortex neoplasms typically involves a combination of imaging techniques, such as CT or MRI scans, and hormonal assessments to determine if the tumor is functional or non-functional. In some cases, a biopsy may be necessary to confirm the diagnosis and differentiate between benign and malignant tumors. Treatment options depend on the type, size, location, and hormonal activity of the neoplasm and may include surgical excision, radiation therapy, chemotherapy, or a combination of these approaches.
Steroidogenic Factor 1 (SF-1 or NR5A1) is a nuclear receptor protein that functions as a transcription factor, playing a crucial role in the development and regulation of the endocrine system. It is involved in the differentiation and maintenance of steroidogenic tissues such as the adrenal glands, gonads (ovaries and testes), and the hypothalamus and pituitary glands in the brain.
SF-1 regulates the expression of genes that are essential for steroid hormone biosynthesis, including enzymes involved in the production of cortisol, aldosterone, and sex steroids (androgens, estrogens). Mutations in the SF-1 gene can lead to various disorders related to sexual development, adrenal function, and fertility.
In summary, Steroidogenic Factor 1 is a critical transcription factor that regulates the development and function of steroidogenic tissues and the biosynthesis of steroid hormones.
Pituitary diseases refer to a group of conditions that affect the pituitary gland, a small endocrine gland located at the base of the brain. The pituitary gland is responsible for producing and secreting several important hormones that regulate various bodily functions, including growth and development, metabolism, stress response, and reproduction.
Pituitary diseases can be classified into two main categories:
1. Pituitary tumors: These are abnormal growths in or around the pituitary gland that can affect its function. Pituitary tumors can be benign (non-cancerous) or malignant (cancerous), and they can vary in size. Some pituitary tumors produce excess hormones, leading to a variety of symptoms, while others may not produce any hormones but can still cause problems by compressing nearby structures in the brain.
2. Pituitary gland dysfunction: This refers to conditions that affect the normal function of the pituitary gland without the presence of a tumor. Examples include hypopituitarism, which is a condition characterized by decreased production of one or more pituitary hormones, and Sheehan's syndrome, which occurs when the pituitary gland is damaged due to severe blood loss during childbirth.
Symptoms of pituitary diseases can vary widely depending on the specific condition and the hormones that are affected. Treatment options may include surgery, radiation therapy, medication, or a combination of these approaches.
Gonadal disorders refer to conditions that affect the function or structure of the gonads, which are the primary reproductive organs. In females, the gonads are the ovaries, and in males, they are the testes. These disorders can result in issues related to sexual development, reproduction, and hormone production.
Examples of gonadal disorders include:
1. Ovarian dysfunction: This includes conditions such as polycystic ovary syndrome (PCOS), premature ovarian failure, and ovarian insufficiency, which can affect menstruation, fertility, and hormone levels.
2. Testicular disorders: These include conditions such as undescended testes, Klinefelter syndrome, and varicocele, which can impact sperm production, male secondary sexual characteristics, and hormone levels.
3. Gonadal dysgenesis: This is a condition where the gonads do not develop properly during fetal development, leading to ambiguous genitalia or sex chromosome abnormalities.
4. Cancer of the gonads: Both ovarian and testicular cancers can affect gonadal function and require prompt medical attention.
5. Gonadal injury or trauma: Injuries to the gonads can impact their function, leading to fertility issues or hormonal imbalances.
Treatment for gonadal disorders depends on the specific condition and its severity. It may involve medications, surgery, hormone replacement therapy, or assisted reproductive technologies.
Metyrapone is a medication that is primarily used in the diagnosis and treatment of Cushing's syndrome, a condition characterized by excessive levels of cortisol hormone in the body. It works as an inhibitor of steroidogenesis, specifically blocking the enzyme 11-beta-hydroxylase, which is involved in the production of cortisol in the adrenal gland.
By inhibiting this enzyme, metyrapone prevents the formation of cortisol and leads to an accumulation of its precursor, 11-deoxycortisol. This can help restore the balance of hormones in the body and alleviate symptoms associated with Cushing's syndrome.
It is important to note that metyrapone should only be used under the supervision of a healthcare professional, as it can have significant side effects and interactions with other medications.
Inappropriate Antidiuretic Hormone (ADH) Syndrome, also known as the Syndrome of Inappropriate Antidiuresis (SIAD), is a condition characterized by the excessive release or action of antidiuretic hormone (ADH) leading to an imbalance of water and electrolytes in the body.
ADH is a hormone produced by the pituitary gland that helps regulate water balance in the body by controlling the amount of urine produced by the kidneys. In normal conditions, ADH levels increase in response to dehydration or decreased blood volume, causing the kidneys to retain water and decrease urine output.
However, in Inappropriate ADH Syndrome, there is an overproduction or inappropriate release of ADH, even when the body does not need it. This can lead to a condition called hyponatremia, which is low sodium levels in the blood. Hyponatremia can cause symptoms such as headache, confusion, seizures, and in severe cases, coma or death.
Inappropriate ADH Syndrome can be caused by various factors, including certain medications, brain tumors, lung diseases, and other medical conditions that affect the production or release of ADH. It is important to diagnose and treat Inappropriate ADH Syndrome promptly to prevent serious complications from hyponatremia. Treatment typically involves addressing the underlying cause and adjusting fluid intake and electrolyte levels as needed.
Empty Sella Syndrome is a condition characterized by the absence or near-absence of the pituitary gland in the sella turcica, a bony structure at the base of the skull that houses the pituitary gland. This can occur due to the herniation of the arachnoid membrane, which surrounds the brain and spinal cord, into the sella turcica, compressing or replacing the pituitary gland.
In some cases, Empty Sella Syndrome may be asymptomatic and discovered incidentally on imaging studies. However, in other cases, it can lead to hormonal imbalances due to the disruption of the pituitary gland's function. Symptoms may include headaches, vision changes, menstrual irregularities, fatigue, and decreased libido. Treatment typically involves addressing any underlying hormonal deficiencies with medication or hormone replacement therapy.
Clobetasol is a topical corticosteroid medication that is used to reduce inflammation and relieve itching, redness, and swelling associated with various skin conditions. It works by suppressing the immune system's response to reduce inflammation. Clobetasol is available in several forms, including creams, ointments, emulsions, and foams, and is usually applied to the affected area once or twice a day.
It is important to use clobetasol only as directed by a healthcare provider, as prolonged or excessive use can lead to thinning of the skin, increased susceptibility to infections, and other side effects. Additionally, it should not be used on large areas of the body or for extended periods without medical supervision.
A melanocortin type 2 receptor (MC2R) is a G protein-coupled receptor that binds melanocortin peptides such as adrenocorticotropic hormone (ACTH). It is primarily expressed in the adrenal gland, specifically in the zona fasciculata of the cortex. Upon activation by ACTH, MC2R stimulates the production and release of steroid hormones, particularly cortisol, through the cAMP signaling pathway. Dysfunction in this receptor can lead to various endocrine disorders such as congenital adrenal hyperplasia and Cushing's disease.
Hormone Replacement Therapy (HRT) is a medical treatment that involves the use of hormones to replace or supplement those that the body is no longer producing or no longer producing in sufficient quantities. It is most commonly used to help manage symptoms associated with menopause and conditions related to hormonal imbalances.
In women, HRT typically involves the use of estrogen and/or progesterone to alleviate hot flashes, night sweats, vaginal dryness, and mood changes that can occur during menopause. In some cases, testosterone may also be prescribed to help improve energy levels, sex drive, and overall sense of well-being.
In men, HRT is often used to treat low testosterone levels (hypogonadism) and related symptoms such as fatigue, decreased muscle mass, and reduced sex drive.
It's important to note that while HRT can be effective in managing certain symptoms, it also carries potential risks, including an increased risk of blood clots, stroke, breast cancer (in women), and cardiovascular disease. Therefore, the decision to undergo HRT should be made carefully and discussed thoroughly with a healthcare provider.
Central nervous system (CNS) cysts are abnormal fluid-filled sacs that develop in the brain or spinal cord. These cysts can be congenital, meaning they are present at birth and develop as a result of abnormal embryonic development, or they can be acquired later in life due to injury, infection, or disease.
CNS cysts can vary in size and may cause symptoms depending on their location and the amount of pressure they place on surrounding brain or spinal cord tissue. Symptoms may include headaches, seizures, weakness, numbness, or difficulty with coordination and balance. In some cases, CNS cysts may not cause any symptoms and may be discovered incidentally during imaging studies performed for other reasons.
There are several types of CNS cysts, including:
1. Arachnoid cysts: These are the most common type of CNS cyst and occur between the layers of the arachnoid membrane that covers the brain and spinal cord.
2. Colloid cysts: These cysts typically develop at the junction of the third and fourth ventricles in the brain and can obstruct the flow of cerebrospinal fluid (CSF), leading to increased intracranial pressure.
3. Ependymal cysts: These cysts arise from the ependymal cells that line the ventricular system of the brain and can cause symptoms by compressing surrounding brain tissue.
4. Neuroglial cysts: These cysts are composed of glial cells, which support and protect nerve cells in the CNS.
5. Pineal cysts: These cysts develop in the pineal gland, a small endocrine gland located near the center of the brain.
Treatment for CNS cysts depends on their size, location, and symptoms. In some cases, observation and monitoring may be all that is necessary. However, if the cyst is causing significant symptoms or is at risk of rupturing or obstructing CSF flow, surgical intervention may be required to remove or reduce the size of the cyst.
Anti-inflammatory agents are a class of drugs or substances that reduce inflammation in the body. They work by inhibiting the production of inflammatory mediators, such as prostaglandins and leukotrienes, which are released during an immune response and contribute to symptoms like pain, swelling, redness, and warmth.
There are two main types of anti-inflammatory agents: steroidal and nonsteroidal. Steroidal anti-inflammatory drugs (SAIDs) include corticosteroids, which mimic the effects of hormones produced by the adrenal gland. Nonsteroidal anti-inflammatory drugs (NSAIDs) are a larger group that includes both prescription and over-the-counter medications, such as aspirin, ibuprofen, naproxen, and celecoxib.
While both types of anti-inflammatory agents can be effective in reducing inflammation and relieving symptoms, they differ in their mechanisms of action, side effects, and potential risks. Long-term use of NSAIDs, for example, can increase the risk of gastrointestinal bleeding, kidney damage, and cardiovascular events. Corticosteroids can have significant side effects as well, particularly with long-term use, including weight gain, mood changes, and increased susceptibility to infections.
It's important to use anti-inflammatory agents only as directed by a healthcare provider, and to be aware of potential risks and interactions with other medications or health conditions.
Pituitary ACTH hypersecretion, also known as Cushing's disease, is a condition characterized by the excessive production of adrenocorticotropic hormone (ACTH) from the pituitary gland. This results in an overproduction of cortisol, a steroid hormone produced by the adrenal glands, leading to a constellation of symptoms known as Cushing's syndrome.
In Cushing's disease, a benign tumor called an adenoma develops on the pituitary gland, causing it to release excess ACTH. This in turn stimulates the adrenal glands to produce more cortisol than necessary. The resulting high levels of cortisol can cause various symptoms such as weight gain, particularly around the trunk and face (central obesity), thinning of the skin, bruising, weakness, fatigue, mood changes, high blood pressure, and an increased risk of infections.
It is important to distinguish Cushing's disease from other causes of Cushing's syndrome, such as cortisol-producing adrenal tumors or exogenous sources of corticosteroid use, as the treatment approach may differ. Treatment for Cushing's disease typically involves surgical removal of the pituitary tumor, with additional medical management and/or radiation therapy in some cases.
Aldosterone is a hormone produced by the adrenal gland. It plays a key role in regulating sodium and potassium balance and maintaining blood pressure through its effects on the kidneys. Aldosterone promotes the reabsorption of sodium ions and the excretion of potassium ions in the distal tubules and collecting ducts of the nephrons in the kidneys. This increases the osmotic pressure in the blood, which in turn leads to water retention and an increase in blood volume and blood pressure.
Aldosterone is released from the adrenal gland in response to a variety of stimuli, including angiotensin II (a peptide hormone produced as part of the renin-angiotensin-aldosterone system), potassium ions, and adrenocorticotropic hormone (ACTH) from the pituitary gland. The production of aldosterone is regulated by a negative feedback mechanism involving sodium levels in the blood. High sodium levels inhibit the release of aldosterone, while low sodium levels stimulate its release.
In addition to its role in maintaining fluid and electrolyte balance and blood pressure, aldosterone has been implicated in various pathological conditions, including hypertension, heart failure, and primary hyperaldosteronism (a condition characterized by excessive production of aldosterone).
Thyrotoxicosis is a medical condition that results from an excess of thyroid hormones in the body, leading to an overactive metabolic state. It can be caused by various factors such as Graves' disease, toxic adenoma, Plummer's disease, or excessive intake of thyroid hormone medication. Symptoms may include rapid heart rate, weight loss, heat intolerance, tremors, and increased sweating, among others. Thyrotoxicosis is not a diagnosis itself but a manifestation of various underlying thyroid disorders. Proper diagnosis and management are crucial to prevent complications and improve quality of life.
Dehydroepiandrosterone sulfate (DHEA-S) is a steroid hormone that is produced by the adrenal glands. It is a modified form of dehydroepiandrosterone (DHEA), which is converted to DHEA-S in the body for storage and later conversion back to DHEA or other steroid hormones, such as testosterone and estrogen. DHEA-S is often measured in the blood as a marker of adrenal function. It is also available as a dietary supplement, although its effectiveness for any medical purpose is not well established.
Esophageal achalasia is a rare disorder of the esophagus, the tube that carries food from the mouth to the stomach. In this condition, the muscles at the lower end of the esophagus fail to relax properly during swallowing, making it difficult for food and liquids to pass into the stomach. This results in symptoms such as difficulty swallowing (dysphagia), regurgitation of food, chest pain, and weight loss. The cause of esophageal achalasia is not fully understood, but it is believed to be related to damage to the nerves that control the muscles of the esophagus. Treatment options include medications to relax the lower esophageal sphincter, botulinum toxin injections, and surgical procedures such as laparoscopic Heller myotomy or peroral endoscopic myotomy (POEM).
X-linked genetic diseases refer to a group of disorders caused by mutations in genes located on the X chromosome. These conditions primarily affect males since they have only one X chromosome and therefore don't have a second normal copy of the gene to compensate for the mutated one. Females, who have two X chromosomes, are typically less affected because they usually have one normal copy of the gene on their other X chromosome.
Examples of X-linked genetic diseases include Duchenne and Becker muscular dystrophy, hemophilia A and B, color blindness, and fragile X syndrome. Symptoms and severity can vary widely depending on the specific condition and the nature of the genetic mutation involved. Treatment options depend on the particular disease but may include physical therapy, medication, or in some cases, gene therapy.
Pituitary function tests are a group of diagnostic exams that evaluate the proper functioning of the pituitary gland, a small endocrine gland located at the base of the brain. The pituitary gland is responsible for producing and releasing several essential hormones that regulate various bodily functions, including growth, metabolism, stress response, reproduction, and lactation.
These tests typically involve measuring the levels of different hormones in the blood, stimulating or suppressing the pituitary gland with specific medications, and assessing the body's response to these challenges. Some common pituitary function tests include:
1. Growth hormone (GH) testing: Measures GH levels in the blood, often after a provocative test using substances like insulin, arginine, clonidine, or glucagon to stimulate GH release.
2. Thyroid-stimulating hormone (TSH) and free thyroxine (FT4) testing: Assesses the function of the thyroid gland by measuring TSH and FT4 levels in response to TRH (thyrotropin-releasing hormone) stimulation.
3. Adrenocorticotropic hormone (ACTH) and cortisol testing: Evaluates the hypothalamic-pituitary-adrenal axis by measuring ACTH and cortisol levels after a CRH (corticotropin-releasing hormone) stimulation test or an insulin tolerance test.
4. Prolactin (PRL) testing: Measures PRL levels in the blood, which can be elevated due to pituitary tumors or other conditions affecting the hypothalamus.
5. Follicle-stimulating hormone (FSH) and luteinizing hormone (LH) testing: Assesses reproductive function by measuring FSH and LH levels, often in conjunction with estradiol or testosterone levels.
6. Gonadotropin-releasing hormone (GnRH) stimulation test: Evaluates gonadal function by measuring FSH and LH levels after GnRH administration.
7. Growth hormone (GH) testing: Measures GH levels in response to various stimuli, such as insulin-like growth factor-1 (IGF-1), glucagon, or arginine.
8. Vasopressin (ADH) testing: Assesses the posterior pituitary function by measuring ADH levels and performing a water deprivation test.
These tests can help diagnose various pituitary disorders, such as hypopituitarism, hyperpituitarism, or pituitary tumors, and guide appropriate treatment strategies.
Hypogonadism is a medical condition characterized by the inability of the gonads (testes in males and ovaries in females) to produce sufficient amounts of sex hormones, such as testosterone and estrogen. This can lead to various symptoms including decreased libido, erectile dysfunction in men, irregular menstrual periods in women, and reduced fertility in both sexes. Hypogonadism may be caused by genetic factors, aging, injury to the gonads, or certain medical conditions such as pituitary disorders. It can be treated with hormone replacement therapy.
The pituitary gland is a small, endocrine gland located at the base of the brain, in the sella turcica of the sphenoid bone. It is often called the "master gland" because it controls other glands and makes the hormones that trigger many body functions. The pituitary gland measures about 0.5 cm in height and 1 cm in width, and it weighs approximately 0.5 grams.
The pituitary gland is divided into two main parts: the anterior lobe (adenohypophysis) and the posterior lobe (neurohypophysis). The anterior lobe is further divided into three zones: the pars distalis, pars intermedia, and pars tuberalis. Each part of the pituitary gland has distinct functions and produces different hormones.
The anterior pituitary gland produces and releases several important hormones, including:
* Growth hormone (GH), which regulates growth and development in children and helps maintain muscle mass and bone strength in adults.
* Thyroid-stimulating hormone (TSH), which controls the production of thyroid hormones by the thyroid gland.
* Adrenocorticotropic hormone (ACTH), which stimulates the adrenal glands to produce cortisol and other steroid hormones.
* Follicle-stimulating hormone (FSH) and luteinizing hormone (LH), which regulate reproductive function in both males and females.
* Prolactin, which stimulates milk production in pregnant and lactating women.
The posterior pituitary gland stores and releases two hormones that are produced by the hypothalamus:
* Antidiuretic hormone (ADH), which helps regulate water balance in the body by controlling urine production.
* Oxytocin, which stimulates uterine contractions during childbirth and milk release during breastfeeding.
Overall, the pituitary gland plays a critical role in maintaining homeostasis and regulating various bodily functions, including growth, development, metabolism, and reproductive function.
Corticotropin-Releasing Hormone (CRH) is a hormone that is produced and released by the hypothalamus, a small gland located in the brain. CRH plays a critical role in the body's stress response system.
When the body experiences stress, the hypothalamus releases CRH, which then travels to the pituitary gland, another small gland located at the base of the brain. Once there, CRH stimulates the release of adrenocorticotropic hormone (ACTH) from the pituitary gland.
ACTH then travels through the bloodstream to the adrenal glands, which are located on top of the kidneys. ACTH stimulates the adrenal glands to produce and release cortisol, a hormone that helps the body respond to stress by regulating metabolism, immune function, and blood pressure, among other things.
Overall, CRH is an important part of the hypothalamic-pituitary-adrenal (HPA) axis, which regulates many bodily functions related to stress response, mood, and cognition. Dysregulation of the HPA axis and abnormal levels of CRH have been implicated in various psychiatric and medical conditions, including depression, anxiety disorders, post-traumatic stress disorder (PTSD), and Cushing's syndrome.
Adrenal insufficiency
Drospirenone
Pubarche
Hypopituitarism
Leydig cell
HFE H63D gene mutation
Adrenocortical hormone
Pheochromocytoma
Megestrol acetate
Lymphocytosis
Non-tropic hormone
Hypoadrenocorticism in dogs
Hyperdynamic circulation
Hyperkalemia
Betamethasone
Waterhouse-Friderichsen syndrome
Course (medicine)
Triple-A syndrome
Băile Tușnad
Paracoccidioidomycosis
Adrenoleukodystrophy
PD-1 and PD-L1 inhibitors
Etomidate
Cushing's syndrome
Acute liver failure
Glucocorticoid
Metyrapone
Gluten-sensitive enteropathy-associated conditions
Fludrocortisone
List of OMIM disorder codes
Adrenal insufficiency - Wikipedia
Adrenal insufficiency | Addison's Disease | MedlinePlus
Blood level -- what high calcium means - Adrenal Insufficiency - MedHelp
Pediatric Adrenal Insufficiency (Addison Disease): Practice Essentials, Anatomy, Etiology
A to Z: Adrenal Insufficiency
Endocrine Society Reading Room | Controversies in Assessment and Management of Adrenal Insufficiency in Cirrhosis | MedPage...
Pathology Outlines - Adrenal insufficiency-diagnosis
Yin Yang House | Addison'S Disease (Adrenal Insufficiency) Related @ Our Forum
JCI - Partial MCM4 deficiency in patients with growth retardation, adrenal insufficiency, and natural killer cell deficiency
Clinical Practice Guidelines : Adrenal crisis and acute adrenal insufficiency
Adrenal insufficiency: a commentary | Journal of Clinical Pathology
Glucocorticoid management of adrenal insufficiency in the UK | Society for Endocrinology
Recognizing the Symptoms of Adrenal Insufficiency Can Help You Heal | BodyLogicMD
Long Term Adrenal Insufficiency Induces Skeletal Muscle Atrophy and Increases the Serum Levels of Active Form Myostatin in Rat...
Iatrogenic adrenal insufficiency as a side-effect of combined treatment of itraconazole and budesonide | European Respiratory...
Treatment of Adrenal Insufficiency in Neonates and Infants (TAIN) | Genetic Alliance UK
Addison's Disease (Adrenal Insufficiency) - Info Packet (Download) | WRF
New guidelines for the management of adrenal insufficiency during operations published | Living with CAH
Genetic and phenotypic spectrum of non-21-hydroxylase-deficiency primary adrenal insufficiency in childhood: data from 111...
Primary Adrenal Insufficiency Guidelines Pocket Guide - Guideline Central
Controlling intracellular cortisol: Can HSD-1 inhibition reduce Cushings syndrome morbidity and minimize adrenal...
A respiratory chain disorder presenting as developemental delay and hypoglycaemia with adrenal insufficiency<...
Celiac Disease & Primary Adrenal Insufficiency | BeyondCeliac.org
Adrenal Insufficiency, ACTH (Cosyntropin) Test and Steroid Interaction | Karine Wong, Pharm.D. | RxEconsult
Adrenal Insufficiency in the Pediatric Emergency Department - Fingerprint - Northwestern Scholars
Adrenal Insufficiency Symptoms and Treatment in Maple Grove - Osseo MN
Educating GPs - free RCGP Adrenal Insufficiency course | Addison's Disease Self-Help Group
Managing Adrenal Insufficiency Symptoms
Oregon - Adrenal Insufficiency United
Adrenal Insufficiency Panel
ACTH25
- This is called secondary adrenal insufficiency (when caused by lack of production of adrenocorticotropic hormone (ACTH) in the pituitary gland) or tertiary adrenal insufficiency (when caused by lack of corticotropin-releasing hormone (CRH) in the hypothalamus). (wikipedia.org)
- Since the adrenal glands are not directly affected, the effect on mineralocorticoid production is minimal, as ACTH primarily affects glucocorticoid production. (wikipedia.org)
- Sheehan's syndrome: Loss of blood flow to the pituitary gland following childbirth Pituitary apoplexy: Bleeding or impaired blood supply to the pituitary gland Tertiary adrenal insufficiency is caused by impairment of the hypothalamus, resulting in a lack of corticotropin-releasing hormone (CRH) production, causing downstream reduction in ACTH production and subsequently decreasing adrenal stimulation. (wikipedia.org)
- Adrenal insufficiency (Addison disease) can be classified as primary, which occurs when the adrenal gland itself is dysfunctional, or secondary, also called central adrenal insufficiency, which occurs when a lack of secretion of corticotropin-releasing hormone (CRH) from the hypothalamus or of adrenocorticotropic hormone (ACTH) from the pituitary leads to hypofunction of the adrenal cortex. (medscape.com)
- A diagnosis of adrenal insufficiency is confirmed if the serum cortisol level is less than 18 mcg/dL in the presence of a markedly elevated serum ACTH concentration and plasma renin activity. (medscape.com)
- Based on normative data of children of various ages, adrenal insufficiency is likely if the serum cortisol concentration is less than 18 mcg/dL 30-60 minutes after administration of 250 mcg of cosyntropin (synthetic ACTH 1-24). (medscape.com)
- When a patient's serum cortisol response to cosyntropin is subnormal but his or her serum ACTH level is not elevated, the possibility of central adrenal insufficiency should be considered. (medscape.com)
- Indeed, according to the National Institute of Diabetes and Digestive and Kidney Diseases , "Anything that affects the pituitary's ability to make ACTH can cause secondary adrenal insufficiency. (bodylogicmd.com)
- Only one patient with an initial pathological ACTH-test subsequently normalised, the other 10 patients improved but had not achieved normalised adrenal function 2-10 months after itraconazole treatment had been discontinued. (ersjournals.com)
- Furthermore, unlike current Cs treatments that are associated with substantial adrenal insufficiency risk, under full and sustained HSD-1 inhibition autonomously produced or ACTH-stimulated cortisol remains elevated in the circulatory pool, available to enter cells and act at GC, MC or non-genomic receptors at concentrations likely sufficient to prevent adrenal insufficiency. (endocrine-abstracts.org)
- Until further direct experience in these conditions is gathered, we still advise caution in patients with modest autonomous cortisol secretion, who may have suppressed ACTH and atrophied normal adrenal tissue, particularly in situations where stress-dose, non-precursor GC steroids should be considered (e.g., use hydrocortisone not cortisone acetate, or prednisolone not prednisone). (endocrine-abstracts.org)
- Cosyntropin is adrenocorticotropic hormone (ACTH), used to test for adrenal insufficiency. (rxeconsult.com)
- If a baseline ACTH level is drawn, then it can be used to differentiate between primary and secondary adrenal insufficiency. (rxeconsult.com)
- Patients with primary adrenal insufficiency will have elevated levels of ACTH. (rxeconsult.com)
- The more common type of AI, secondary adrenal insufficiency is caused by the impairment of the pituitary gland (a small gland at the base of the brain) in which it fails to produce enough adrenocorticotropic hormone (ACTH). (endocrinology-centers.com)
- ACTH is responsible for stimulating the adrenal glands to produce cortisol. (endocrinology-centers.com)
- Discounted Labs' basic adrenal insufficiency panel includes cortisol, ACTH, and DHEA as a starting point. (discountedlabs.com)
- Depending on lab test results, physicians may choose to do an ACTH stimulation test, renin test, aldosterone test, potassium, sodium, and a CT scan of the adrenal glands. (discountedlabs.com)
- The pituitary gland produces adrenocorticotropic hormone (ACTH), which stimulates the adrenal glands to produce other hormones. (medicalnewstoday.com)
- Secondary adrenal deficiency can also develop when a person uses steroid drugs that affect the hypothalamus and the pituitary gland and prevent the body from producing ACTH. (medicalnewstoday.com)
- Other conditions that should be considered include adrenocorticotropic hormone (ACTH) receptor defect, adrenoleukodystrophy and adrenomyeloneuropathy, autoimmune polyglandular endocrinopathy syndromes, infectious adrenalitis (eg, in association with human immunodeficiency [HIV] infection or tuberculosis [TB]), adrenal hemorrhage, lipoid adrenal hyperplasia, and Wolman disease. (medscape.com)
- Secondary adrenal failure can also occur with adrenocorticotropic hormone (ACTH) deficiency caused by disorders of the pituitary. (unboundmedicine.com)
- Without ACTH, the adrenals do not receive a signal to make cortisol. (medicalnewstoday.com)
- A disorder characterized by decreased secretion of corticotropin (ACTH) by the pituitary gland leading to adrenal insufficiency (e.g., low levels of cortisol). (medbullets.com)
- The most common cause is exogenous steroid administration (tertiary adrenal insufficiency) resulting in atrophy of the adrenal cortex due to insufficient ACTH release from the pituitary gland, and the subsequent inability to produce endogenous glucocorticoids. (ai-online.info)
Pituitary15
- Adrenal insufficiency can also occur when the pituitary gland or the hypothalamus do not produce adequate amounts of the hormones that assist in regulating adrenal function. (wikipedia.org)
- 10 d) central adrenal insufficiency (eg, a patient who recently underwent surgery of the hypothalamus or pituitary regions). (medscape.com)
- In central adrenal insufficiency, the pituitary, a small gland beneath the brain, does not make enough of the hormone that triggers cortisol production. (childrensmn.org)
- Dysfunction of hypothalamic-pituitary-adrenal (HPA) axis is a common but underrecognized occurrence in cirrhosis. (medpagetoday.com)
- It is a life-threatening disorder that can result from primary adrenal failure or secondary adrenal disease due to impairment of the hypothalamic-pituitary axis. (bodylogicmd.com)
- A recent case of iatrogenic Cushing's syndrome and complete suppression of the pituitary-adrenal-axis in a patient with cystic fibrosis (CF) and allergic bronchopulmonary aspergillosis treated with itraconazole as an antifungal agent, and budesonide as an anti-inflammatory agent led to a systematic assessment of this axis and gonadal function in all patients treated with itraconazole in the authors' CF centre. (ersjournals.com)
- The frequency of suppression of the pituitary-adrenal-axis and gonadal steroidogenesis due to pharmacological interaction of itraconazole and budesonide was prospectively studied in a group of 31 patients with CF and six patients with chronic granulomateous disease (CGD) and compared to a control group of 30 CF patients who had been tested as part of a pretransplantation programme. (ersjournals.com)
- Synthesis and secretion of cortisol by the adrenal gland are controlled by a negative feedback mechanism within the hypothalamus-pituitary-adrenal cortex-axis. (discountedlabs.com)
- If the adrenal glands are undamaged but still unable to produce aldosterone or cortisol because of other reasons, such as pituitary gland abnormalities, this condition is called secondary adrenal insufficiency. (iaedjournal.org)
- Patients with AI include patients with primary adrenal insufficiency such as Addison's disease and congenital adrenal hyperplasia, and hypothalamo-pituitary damage from tumours or surgery. (rcpjournals.org)
- 500 mcg/day are at risk of adrenal insufficiency due to hypothalamo-pituitary axis suppression and should be issued with an NHS Steroid Emergency Card. (rcpjournals.org)
- Secondary insufficiency occurs from disorders of the pituitary gland, which produces hormones to regulate the adrenal gland. (unboundmedicine.com)
- Determine if the patient has a history of recent infection, use of corticosteroids such as prednisone, or adrenal or pituitary surgery. (unboundmedicine.com)
- Adrenal insufficiency may be caused by a disorder of the adrenal glands, a disorder of the pituitary gland, or by certain drugs. (msdmanuals.com)
- Rarer causes of adrenal insufficiency are Addison's disease (primary adrenal insufficiency), which results in absence of all endogenous steroid production, as well as pituitary and hypothalamic tumors or lesions (secondary adrenal insufficiency). (ai-online.info)
Congenital10
- Addison's disease), failure of development (e.g. adrenal dysgenesis), or enzyme deficiency (e.g. congenital adrenal hyperplasia). (wikipedia.org)
- Adrenal insufficiency can further be classified as congenital or acquired (see Etiology). (medscape.com)
- Babies and children with adrenal insufficiency (in most cases they have the genetic condition congenital adrenal hyperplasia (CAH) need treatment with hydrocortisone because their bodies do not produce enough cortisol. (geneticalliance.org.uk)
- The study, run by Guy's and St Thomas' NHS Foundation Trust, London UK, will evaluate the effects of different doses of the study drug, Lu AG13909 in adult participants with congenital adrenal hyperplasia (CAH). (livingwithcah.com)
- Altered Emotion Perception Linked to Structural Brain Differences in Youth With Congenital Adrenal Hyperplasia" From Volume 25, Fall 2023 Cares Foundataion Newsletter "Conclusion: Findings suggest that youth with CAH perceive emotive stimuli as more unpleasant. (livingwithcah.com)
- Addison's disease, , the auto-immune type of primary adrenal insufficiency, and congenital adrenal hyperplasia can manifest as adrenal insufficiency. (discountedlabs.com)
- Congenital adrenal hypoplasia: clinical spectrum, experience with hormonal diagnosis, and report on new point mutations of the DAX-1 gene. (medscape.com)
- There is also a rare form of X-linked congenital adrenal insufficiency that is associated with mutations in the NR0B1 gene that produce the DAX1 protein. (unboundmedicine.com)
- Congenital adrenal hyperplasia is characterized by autosomal recessive mutations in one of the enzymes required for cortisol synthesis, impairing cortisol production. (unboundmedicine.com)
- Works to improve the lives of the congenital adrenal hyperplasia (CAH) community and to provide support, advocacy, education, and research. (pediatricadrenalinsufficiency.com)
Management of adrenal insufficiency2
- There are huge variations in reported prevalence due to the complexities and controversies that surround both assessment and management of adrenal insufficiency (AI) in patients with liver cirrhosis. (medpagetoday.com)
- Diagnosis and management of adrenal insufficiency. (teachim.org)
Crisis33
- This is called an adrenal crisis and requires immediate medical treatment, which usually includes additional hormone treatment and fluids given through a vein. (childrensmn.org)
- An adrenal crisis is a physiological event caused by an acute relative insufficiency of adrenal hormones. (rch.org.au)
- Sometimes symptoms can appear suddenly, in a life-threatening complication called acute adrenal failure (also known as an addisonian crisis). (beyondceliac.org)
- An adrenal crisis occurs when there is a sudden, extreme worsening of these symptoms. (endocrinology-centers.com)
- In most cases the symptoms will cause a patient to seek treatment before a crisis is reached, but occasionally adrenal insufficiency symptoms are not diagnosed until an adrenal crisis occurs. (endocrinology-centers.com)
- If not treated immediately, adrenal crisis can be fatal. (endocrinology-centers.com)
- In cases of adrenal crisis, doctors may give IV doses of these replacement hormones. (endocrinology-centers.com)
- It also covers adrenal crisis, how to recognise this condition, and the emergency treatment which should be delivered before hospital transfer. (addisonsdisease.org.uk)
- Primary adrenal insufficiency is more commonly associated with adrenal crisis, in contrast with central (secondary and tertiary), because of the mineralocorticoid deficiency which results in hypovolemia. (teachim.org)
- Adrenal crisis is a syndrome of hypotension/shock with possible fever, abdominal pain, nausea, and fatigue. (teachim.org)
- What is Adrenal Crisis? (navigatingald.com)
- Managing the adrenal aspects of ALD is an important part of your child's care because adrenal insufficiency can lead to adrenal crisis if left unchecked. (navigatingald.com)
- Adrenal crisis refers to a life-threatening condition that occurs when there is not enough cortisol, a hormone produced by the adrenal gland. (navigatingald.com)
- Adrenal crisis can occur more frequently after an infection, trauma, or another stressor. (navigatingald.com)
- If your child has been diagnosed with adrenal insufficiency, it's important to recognize signs of potential stress that can lead to an adrenal crisis. (navigatingald.com)
- now include this answer choice: "Acute adrenal insufficiency/crisis or Addison's disease. (iaedjournal.org)
- That's why we are going to help you understand more about Addison's disease and how you can help callers experiencing acute adrenal insufficiency or an Addisonian crisis. (iaedjournal.org)
- 7 As mentioned previously, symptoms can occur suddenly-a condition called acute adrenal failure or an Addisonian crisis. (iaedjournal.org)
- This may be caused by inadequate glucocortiocid therapy and adrenal crisis. (medscape.com)
- This article provides answers to the important daily clinical questions, such as correct dose finding, dose adaptation in special situations, e g, pregnancy, improvement of quality of life and measures for protection from adrenal crisis. (medscape.com)
- Adrenal insufficiency (AI) is an often-unrecognised endocrine disorder, which can lead to adrenal crisis and death if not identified and treated. (rcpjournals.org)
- Omission of steroids in patients with AI, particularly during physiological stress such as an intercurrent illness or surgery, can also lead to an adrenal crisis. (rcpjournals.org)
- This guidance will go through causes of adrenal insufficiency, groups at risk of an adrenal crisis, emergency management and management for surgical procedures. (rcpjournals.org)
- A new NHS Steroid Emergency Card has been developed to be carried by patients at risk of adrenal crisis. (rcpjournals.org)
- We hope the new emergency card and this guidance will increase awareness of the need to start steroids promptly in patients at risk of an adrenal crisis, particularly those presenting in the emergency department or to acute medicine teams and those undergoing surgery or invasive procedures. (rcpjournals.org)
- All patients with AI or steroid dependence are at risk of an adrenal crisis during intercurrent illness or an invasive procedure/surgery. (rcpjournals.org)
- All healthcare professionals should be aware of the patient groups at risk of an adrenal crisis. (rcpjournals.org)
- All doctors should be aware of the need to start steroids promptly in patients at risk of an adrenal crisis, either at replacement or stress doses, particularly when presenting in the emergency department or to acute medicine teams, undergoing surgery, or invasive procedures. (rcpjournals.org)
- Approximately 8% of people with adrenal insufficiency require hospital treatment each year for adrenal crisis (see Adrenal Crisis, Acute ). (unboundmedicine.com)
- How can I be prepared for an adrenal crisis? (pediatricadrenalinsufficiency.com)
- Without enough cortisol, a person may experience an adrenal crisis. (medicalnewstoday.com)
- If a person shows any signs of an adrenal crisis, they should seek immediate medical help. (medicalnewstoday.com)
- Without treatment, an adrenal crisis can be fatal. (medicalnewstoday.com)
Pediatric Adrenal Insufficiency2
- This website contains information on pediatric adrenal insufficiency from public, organizational and medical sources. (pediatricadrenalinsufficiency.com)
- Information about Pediatric Adrenal Insufficiency from the Pediatric Endocrine Society in Spanish. (pediatricadrenalinsufficiency.com)
Cortex21
- The adrenal glands, also referred to as adrenal cortex normally secretes glucocorticoids (primarily cortisol), mineralocorticoids (primarily aldosterone), and androgens. (wikipedia.org)
- Regulation of the adrenal cortex. (medscape.com)
- The adrenal cortex is divided into 3 major anatomic zones. (medscape.com)
- Addison's Disease is an inadequate release of hormones (especially, though not exclusively, cortisol) by the adrenal cortex. (bodylogicmd.com)
- Autoimmune adrenalitis results from the destruction of the adrenal cortex, which leads to deficiencies in glucocorticoids, mineralocorticoids, and adrenal androgens. (byjus.com)
- Primary adrenal insufficiency or Addison's disease occurs when the adrenal cortex has been destroyed. (byjus.com)
- There are different causes for primary adrenal insufficiency, but 70-90 per cent of cases are due to an autoimmune disorder and caused when the body's own immune system attacks the outer layer (cortex) of the adrenal glands , the exact fact behind this is unaware. (byjus.com)
- Like other glucocorticosteroids, cortisol is synthesized from the common precursor cholesterol in the zona fasciculata of the cortex of the adrenal gland. (discountedlabs.com)
- About 75% of cases of Addison's disease occur when the body's immune system attacks the adrenal glands, causing continual damage to the adrenal cortex-the outermost layers of the glands that secrete cortisol and aldosterone. (iaedjournal.org)
- Symptoms often do not develop until 90% of the adrenal cortex has been damaged. (iaedjournal.org)
- The adrenal glands consist of two layers: the medulla, which is the interior layer, and the cortex, the outer layer. (medicalnewstoday.com)
- Addison's disease occurs when damage to the adrenal cortex disrupts hormone production in the adrenal glands. (medicalnewstoday.com)
- This condition results from direct injury to the adrenal cortex. (medicalnewstoday.com)
- Stewart, PM. The adrenal cortex. (medscape.com)
- Lalli E, Sassone-Corsi P. DAX-1 and the adrenal cortex. (medscape.com)
- Now, there are two adrenal glands , one above each kidney, and each one has an inner layer called the medulla and an outer layer called the cortex which is subdivided into three more layers, the zona glomerulosa, zona fasciculata, and the zona reticularis. (osmosis.org)
- Addison disease, or primary adrenal insufficiency, occurs rarely, but when it occurs, there is loss of at least 90% of the adrenal cortex. (unboundmedicine.com)
- The adrenal glands have two parts: the cortex and the medulla. (medicalnewstoday.com)
- Most tumors that affect the adrenal cortex are adenomas. (medicalnewstoday.com)
- These are benign tumors of the adrenal cortex. (medicalnewstoday.com)
- Although rare, this cancer can affect the cortex, which is the outer part of the adrenal gland. (medicalnewstoday.com)
Acute7
- Potassium is generally not needed in acute situations, especially in patients with primary adrenal insufficiency, who are often hyperkalemic. (medscape.com)
- Anaesthetists must be familiar with the symptoms and signs of acute adrenal insufficiency so that inadequate supplementation or undiagnosed adrenal insufficiency can be detected and treated promptly, as delays may prove fatal. (livingwithcah.com)
- You may be unfamiliar with acute adrenal insufficiency or Addison's disease and unsure when you would select that answer choice. (iaedjournal.org)
- While rare, symptoms can develop quickly, causing acute adrenal failure. (iaedjournal.org)
- Antiphospholipid syndrome occasionally results in acute adrenal insufficiency (Addison disease) secondary to bilateral adrenal hemorrhage. (medscape.com)
- Acute adrenal insufficiency is a rare complication that can manifest in the perioperative period. (ai-online.info)
- It should be noted that patients with Addison's disease are at higher risk for developing acute adrenal insufficiency due to a lack of both glucocorticoid and mineralcorticoid production. (ai-online.info)
Hormones18
- Adrenal insufficiency is a condition in which the adrenal glands do not produce adequate amounts of steroid hormones. (wikipedia.org)
- Addison disease happens if the adrenal glands don't make enough of these hormones. (medlineplus.gov)
- In other words, adrenal insufficiency is defined by a lack or dysfunction of critical hormones. (bodylogicmd.com)
- Adrenal insufficiency is a hormonal disorder caused by the failure of the adrenal glands to produce sufficient amounts of cortisol and aldosterone hormones. (byjus.com)
- The adrenal glands, located atop each of the kidneys, produce steroid hormones vital to the body's metabolism and other bodily functions, especially its stress response. (endocrinology-centers.com)
- When the adrenal glands are unable to produce enough of these hormones, your body can suffer serious reactions which can lead to adrenal insufficiency (AI). (endocrinology-centers.com)
- These tests stimulate the release of the adrenal hormones. (endocrinology-centers.com)
- Your child's doctor will manage adrenal insufficiency with steroids or medication that replace the hormones that their body isn't making. (navigatingald.com)
- Sitting on top of the kidneys are two small adrenal glands that produce two essential hormones: cortisol and aldosterone. (iaedjournal.org)
- Consequently, the adrenal glands will also produce lower levels of hormones. (medicalnewstoday.com)
- Primary adrenal insufficiency , is a rare endocrine disorder that happens when the adrenal gland isn't able to produce enough of the hormones that the body needs, particularly aldosterone and cortisol . (osmosis.org)
- Primary adrenal insufficiency , also known as Addison's disease, is a chronic condition in which the adrenal glands fail to produce enough cortisol and mineralocorticoid hormones. (osmosis.org)
- Adrenal insufficiency occurs when the adrenal glands do not produce adequate amounts of hormones to support the body's function. (unboundmedicine.com)
- Sometimes, the adrenal glands produce too much or not enough of their hormones. (medicalnewstoday.com)
- In adrenal insufficiency, the adrenal glands do not produce enough adrenal hormones. (msdmanuals.com)
- In both types of adrenal insufficiency, the adrenal glands produce an inadequate amount of one or more adrenal hormones. (msdmanuals.com)
- When the adrenal glands become underactive, they tend to produce inadequate amounts of all of the adrenal hormones, including corticosteroids (particularly cortisol ) and mineralocorticoids (particularly aldosterone, which controls blood pressure and the levels of salt [ sodium chloride ] and potassium in the body). (msdmanuals.com)
- The adrenal glands also stimulate the production of small amounts of testosterone and estrogen and other similar sex hormones (androgens, such as dehydroepiandrosterone [DHEA]), levels of which also are reduced in people with adrenocortical insufficiency. (msdmanuals.com)
Forms of adrenal insufficiency1
- Glucocorticoid replacement is required in all forms of adrenal insufficiency. (medscape.com)
People with adrenal insufficiency2
- However, some people with adrenal insufficiency will have no symptoms unless they're exposed to stress. (childrensmn.org)
- The major cause of illness or death for people with adrenal insufficiency is a delay in making the diagnosis, or failure to begin appropriate therapy with glucocorticoids and/or mineralocorticoids. (unboundmedicine.com)
Tertiary2
- Adrenal insufficiency can be described as primary, secondary or tertiary depending on the causes of the condition. (byjus.com)
- In cases of tertiary adrenal insufficiency, a history of exogenous steroid use within the past 3 months is a useful history to elicit. (ai-online.info)
Types of adrenal1
- There are three major types of adrenal insufficiency, depending on the affected organ. (wikipedia.org)
Autoimmune9
- Addison's disease (also called autoimmune adrenalitis), which has been identified to be the cause of 80-90% of primary adrenal insufficiency cases since 1950. (wikipedia.org)
- People with primary adrenal insufficiency often have autoimmune conditions too, including celiac disease. (beyondceliac.org)
- Adrenal insufficiency, or Addison disease, has many causes, the most common of which are autoimmune adrenalitis. (byjus.com)
- Commonly known as Addison's disease , primary adrenal insufficiency is a rare disorder often triggered by an autoimmune disease and is an impairment of the adrenal glands in which they fail to produce enough cortisol. (endocrinology-centers.com)
- Addison's disease, or adrenal insufficiency, is usually an autoimmune disease, resulting from a faulty immune response. (medicalnewstoday.com)
- This can be caused by an autoimmune disorder, infection, or causes of damage to the adrenal glands. (osmosis.org)
- It is not known exactly why this occurs, but it is believed to be related to an autoimmune response that results in the slow destruction of adrenal tissue. (unboundmedicine.com)
- Adrenal insufficiency is often seen in families in association with other autoimmune disorders, most commonly with autoimmune polyendocrine syndrome (APS). (unboundmedicine.com)
- Adrenal insufficiency may be caused by an autoimmune reaction, cancer, an infection, or some other disease. (msdmanuals.com)
Aldosterone6
- Mineralocorticoid replacement is required only in primary adrenal insufficiency, because aldosterone secretion is reduced in primary adrenal insufficiency but not in central adrenal insufficiency. (medscape.com)
- The zona glomerulosa produces aldosterone, and the zonae fasciculata and reticularis together produce cortisol and adrenal androgens. (medscape.com)
- The adrenal glands may also not produce enough aldosterone, which regulates sodium absorption. (beyondceliac.org)
- 1 Addison's disease is a rare disorder of the adrenal glands in which damaged glands do not produce enough aldosterone or cortisol. (iaedjournal.org)
- Adrenal insufficiency is characterized by the decreased production of cortisol, aldosterone, and androgen. (unboundmedicine.com)
- These include Addison's disease, Cushing's syndrome, and adrenal cancer, as well as high blood pressure due to the overproduction of aldosterone. (medicalnewstoday.com)
Mineralocorticoid3
- Since the adrenal glands are directly affected, mineralocorticoid production is also reduced. (wikipedia.org)
- Mineralocorticoid and gonadal insufficiency was not observed in any of the patients. (ersjournals.com)
- Primary adrenal insufficiency is treated with glucocorticoid and mineralocorticoid replacement therapy. (medscape.com)
Symptoms of adrenal6
- By recognizing the symptoms of adrenal insufficiency, you can ensure that you get the support you need to restore healthy function and start on the path to better health. (bodylogicmd.com)
- That's why it is vital to recognize the symptoms of adrenal insufficiency as early as possible. (bodylogicmd.com)
- The symptoms of adrenal insufficiency are varied and can range in severity from mild to debilitating. (bodylogicmd.com)
- And it's easy to understand why-many of the symptoms of adrenal insufficiency can be brushed off as the logical outcome of a stressful lifestyle , attributed to the natural aging process, or seen as a manifestation of burnout syndrome . (bodylogicmd.com)
- Because the symptoms of adrenal insufficiency can present gradually, early diagnosis is uncommon. (endocrinology-centers.com)
- The symptoms of adrenal insufficiency can be difficult to spot. (medicalnewstoday.com)
Diagnosis of adrenal4
- [ 4 ] Therefore, the diagnosis of adrenal insufficiency in premature infants remains problematic. (medscape.com)
- What Lab Tests are Used to Initiate Diagnosis of Adrenal Insufficiency? (discountedlabs.com)
- Emergency treatment should not be delayed while waiting to confirm a diagnosis of adrenal insufficiency. (rcpjournals.org)
- Diagnosis of adrenal insufficiency in children: a survey among pediatric endocrinologists in North America. (bvsalud.org)
Hemorrhage3
- Computed tomography (CT) scanning is the imaging study of choice in the evaluation of adrenal insufficiency and helps to identify adrenal hemorrhage, calcifications, and infiltrative disease. (medscape.com)
- Spontaneous adrenal hemorrhage associated with transient antiphospholipid antibody in a child. (medscape.com)
- Tuberculosis, histoplasmosis, AIDS, malignancies, and hemorrhage into the adrenal glands have all been associated with destruction of the adrenal glands. (unboundmedicine.com)
Risk of adrenal insufficiency1
- People with certain genetic features and conditions have a higher risk of adrenal insufficiency. (medicalnewstoday.com)
Type of adrenal insufficiency2
- A temporary type of adrenal insufficiency also can occur in people who have been treated with high doses of cortisol-like medications (such as prednisone) when the medicine is decreased or stopped. (childrensmn.org)
- This is, of course, a type of adrenal insufficiency. (bodylogicmd.com)
Treatment of Adrenal Insufficiency1
- The length of treatment of adrenal insufficiency is often dependent on whether you have primary or secondary AI. (endocrinology-centers.com)
Atrophy1
- Idiopathic adrenal atrophy is the most common cause of primary adrenal insufficiency. (unboundmedicine.com)
Suppression4
- Suppression of the adrenal glucocorticoid synthesis was observed in 11 of 25 cystic fibrosis patients treated with both itraconazole and budesonide. (ersjournals.com)
- Effects of Etomidate on Adrenal Suppression: A Review of Intubated Septic Patients. (teachim.org)
- Megestrol acetate in pediatric oncology patients may lead to severe, symptomatic adrenal suppression. (medscape.com)
- Suppression of Adrenal Function. (msdmanuals.com)
Known as Addison's disease1
- Primary adrenal insufficiency is also known as Addison's disease and hypocortisolism. (beyondceliac.org)
Addison1
- See also Addison Disease (Adrenal Insufficiency). (medscape.com)
Addison's Disease Self-Help2
- This collaborative initiative between the Addison's Disease Self-Help Group (ADSHG) and RCGP provides vital information regarding Addison's disease and adrenal insufficiency directly to GPs at their desks, free of charge. (addisonsdisease.org.uk)
- I'm raising money for the Addison's Disease Self Help Group so that they can continue to support people with Addison's and adrenal insufficiency. (addisonsdisease.org.uk)
Patients16
- Clinical suspicion is important because the presentation of patients with adrenal insufficiency may be insidious and subtle. (medscape.com)
- Patients with adrenal insufficiency are generally hypovolemic and may be hypoglycemic, hyponatremic, or hyperkalemic. (medscape.com)
- Not only is low cortisol associated with impaired quality of life, patients with adrenal insufficiency also have higher mortality rates than those with healthy adrenal function. (bodylogicmd.com)
- The aim of this study was to evaluate adrenal and gonadal function in patients treated with itraconazole with or without budesonide. (ersjournals.com)
- Eleven of the 25 patients treated with both itraconazole and budesonide had adrenal insufficiency. (ersjournals.com)
- In patients treated with this combination, screening for adrenal insufficiency at regular intervals is suggested. (ersjournals.com)
- The Society for Endocrinology, the Association of Anaesthetists and the Royal College of Physicians have published new " Guidelines for the management of glucocorticoids during the peri-operative period for patients with adrenal insufficiency . (livingwithcah.com)
- The guidelines provide eight recommendations and aim to ensure that patients with adrenal insufficiency are identified and adequately supplemented with glucocorticoids during the peri-operative period. (livingwithcah.com)
- Multiple studies show an increased risk of celiac disease among patients with primary adrenal insufficiency. (beyondceliac.org)
- One study also showed that patients with celiac disease were at an increased risk of developing primary adrenal insufficiency. (beyondceliac.org)
- Once diagnosed with adrenal insufficiency, most patients will need to take medicines on a daily basis. (byjus.com)
- Duration of adrenal inhibition following a single dose of etomidate in critically ill patients. (medscape.com)
- What is the Best Long-term Management Strategy for Patients With Primary Adrenal Insufficiency? (medscape.com)
- Recent data revealed that health-related quality of life in adrenal insufficiency is impaired in many patients and that patients with adrenal insufficiency are also threatened by an increased mortality and morbidity. (medscape.com)
- Large, searchable clinical databases allow us to track outcomes in greater numbers of patients with adrenal insufficiency, but not without a few glitches, notes Dr Plotzker. (medscape.com)
- Hyponatremia in COVID-19 Patients With Adrenal Insufficiency and Its Relation to Mortality and Survival Scores. (who.int)
Secretion1
- This stimulates the synthesis and secretion of cortisol by the adrenal gland. (discountedlabs.com)
Androgens1
- Adrenal insufficiency is the clinical manifestation of deficient production or action of glucocorticoids, with or without deficiency also in mineralocorticoids and adrenal androgens. (bodylogicmd.com)
Etiology1
- CT scan-guided fine-needle aspiration sometimes helps in diagnosing the etiology of infiltrative adrenal disease. (medscape.com)
Impairment of the adrenal glands1
- Primary adrenal insufficiency is due to impairment of the adrenal glands, resulting in a lack of glucocorticoid production. (wikipedia.org)
Gland itself3
- Adrenal insufficiency can be caused by dysfunction of the adrenal gland itself, whether by destruction (e.g. (wikipedia.org)
- The reason it's called "primary" is that the underlying problem is localized to the adrenal gland itself, rather than a problem of a hormone that acts on the adrenal gland or elsewhere in the body . (osmosis.org)
- This condition develops when the adrenal gland itself does not function well and cannot make enough cortisol. (medicalnewstoday.com)
Hyponatremia1
- This case highlights the Brugada phenocopy in the setting of moderate hyperkalemia and severe hyponatremia from adrenal insufficiency that resolves with treatment of the underlying metabolic disturbance. (uic.edu)
Enough cortisol4
- Primary adrenal insufficiency is a rare condition where the adrenal glands (located just above the kidneys) don't produce enough cortisol, which is a hormone that regulates stress and stress reactions. (beyondceliac.org)
- If there is minimal or no change from baseline, the test is positive for adrenal insufficiency which means that the patient is not producing enough cortisol. (rxeconsult.com)
- When the adrenal glands do not make enough cortisol, it is known as adrenal insufficiency. (medicalnewstoday.com)
- This means that the adrenals cannot make enough cortisol. (medicalnewstoday.com)
Disorder2
- Adrenal insufficiency is a rare endocrine or hormonal disorder that affects about 2 or 3 individuals in millions. (byjus.com)
- When this happens, it is known as an adrenal gland disorder. (medicalnewstoday.com)
Dysfunction1
- Grant DB, Barnes ND, Dumic M, Ginalska-Malinowska M, Milla PJ, von Petrykowski W. Neurological and adrenal dysfunction in the adrenal insufficiency/alacrima/achalasia (3A) syndrome. (medscape.com)
Occurs1
- This cancer occurs in childhood and may begin in the medulla, which is the inner part of the adrenal gland. (medicalnewstoday.com)