Anti-leishmanial activity of alkaloidal extract from Aspidosperma ramiflorum. (1/18)
Infections due to protozoa of the genus Leishmania are a major worldwide health problem, with high endemicity in developing countries. The drugs of choice for the treatment of leishmaniasis are the pentavalent antimonials (SbV), which present renal and cardiac toxicity. Besides, the precise chemical structure and mechanism of action of these drugs are unknown up to date. In order to find new drugs against leishmaniasis, we have been studying extracts of Brazilian trees. In the present study, we have evaluated the effectiveness of an alkaloid extract of Aspidosperma ramiflorum Muell. Arg. (Apocynaceae), against the extracellular forms promastigotes of L. (L.) amazonensis and L. (V.) braziliensis. The alkaloid extract of A. ramiflorum was much more effective against L. (L.) amazonensis (LD50 < 47 microg/ml) than L. (V.) braziliensis. Based on these in vitro results against L. (L.) amazonensis new studies should be made to find the compounds with anti-leishmanial activity. (+info)Revisiting a classic approach to the Aspidosperma alkaloids: an intramolecular Schmidt reaction mediated synthesis of (+)-aspidospermidine. (2/18)
[reaction: see text] A total synthesis of (+)-aspidospermidine (1) is described. The key reactions used in the synthesis of this pentacyclic Aspidosperma alkaloid were a deracemizing imine alkylation/Robinson annulation sequence, a selective "redox ketalization", and an intramolecular Schmidt reaction. A Fischer indolization step carried out on a tricyclic ketone mirrored the sequence reported by Stork and Dolfini in their classic aspidospermine synthesis. (+info)Antibacterial activity of indole alkaloids from Aspidosperma ramiflorum. (3/18)
We evaluated the antibacterial activities of the crude methanol extract, fractions (I-V) obtained after acid-base extraction and pure compounds from the stem bark of Aspidosperma ramiflorum. The minimum inhibitory concentration (MIC) was determined by the microdilution technique in Mueller-Hinton broth. Inoculates were prepared in this medium from 24-h broth cultures of bacteria (10(7) CFU/mL). Microtiter plates were incubated at 37 masculineC and the MICs were recorded after 24 h of incubation. Two susceptibility endpoints were recorded for each isolate. The crude methanol extract presented moderate activity against the Gram-positive bacteria B. subtilis (MIC = 250 microg/mL) and S. aureus (MIC = 500 microg/mL), and was inactive against the Gram-negative bacteria E. coli and P. aeruginosa (MIC > 1000 microg/mL). Fractions I and II were inactive against standard strains at concentrations of < or =1000 microg/mL and fraction III displayed moderate antibacterial activity against B. subtilis (MIC = 500 microg/mL) and S. aureus (MIC = 250 microg/mL). Fraction IV showed high activity against B. subtilis and S. aureus (MIC = 15.6 microg/mL) and moderate activity against E. coli and P. aeruginosa (MIC = 250 microg/mL). Fraction V presented high activity against B. subtilis (MIC = 15.6 microg/mL) and S. aureus (MIC = 31.3 microg/mL) and was inactive against Gram-negative bacteria (MIC > 1000 microg/mL). Fractions III, IV and V were then submitted to bioassay-guided fractionation by silica gel column chromatography, yielding individual purified ramiflorines A and B. Both ramiflorines showed significant activity against S. aureus (MIC = 25 microg/mL) and E. faecalis (MIC = 50 microg/mL), with EC50 of 8 and 2.5 microg/mL for ramiflorines A and B, respectively, against S. aureus. These results are promising, showing that these compounds are biologically active against Gram-positive bacteria. (+info)Formal synthesis of aspidosperma alkaloids via the intramolecular [3 + 2] cycloaddition of 2-azapentdienyllithiums. (4/18)
[reaction: see text] A formal synthesis of the Aspidosperma alkaloids aspidospermidine, aspidospermine, and quebrachamine is reported through an efficient preparation of Stork's penultimate intermediate. The key step of the sequence involved an intramolecular [3 + 2] cycloaddition of the 2-azapentadienyllithium 21 formed in situ from the corresponding imine 1, which after N-alkylation of the resulting cycloadduct provided 2 in excellent yield. The synthesis represents a new disconnection of the classical tricyclic ketone used for appendage of the requisite indole. (+info)Application of the Rh(II) cyclization/cycloaddition cascade for the total synthesis of (+/-)-aspidophytine. (5/18)
[Structure: see text] A new strategy for the synthesis of (+/-)-aspidophytine has been developed and is based on a Rh(II)-catalyzed cyclization/dipolar cycloaddition sequence. The resulting [3+2]-cycloadduct undergoes an efficient Lewis acid mediated cascade that rapidly provides the complete skeleton of aspidophytine. The synthesis also features a mild decarbomethoxylation reaction. (+info)Toward general access to the aspidosperma-type terpenoid indole alkaloids: synthesis of the key 3,3-disubstituted piperidones through enantioselective intramolecular heck-type reaction of chloroformamides. (6/18)
An enantioselective intramolecular Heck-type reaction of chloroformamides has been developed for the synthesis of 3,3-disubstituted piperidones. The desired piperidone was formed in the presence of a palladium catalyst, an optically active phosphoramidite ligand, K3PO4 and Ag3PO4. The obtained piperidone was converted to epieburnamonine. (+info)Highly efficient molybdenum-based catalysts for enantioselective alkene metathesis. (7/18)
(+info)Total synthesis of (+)-fendleridine (aspidoalbidine) and (+)-1-acetylaspidoalbidine. (8/18)
(+info)Aspidosperma is a genus of flowering plants in the dogbane family Apocynaceae, characterized by their milky sap and alkaloid-containing bark, which has been used in traditional medicine, although some species are known to be toxic if ingested or handled improperly.
"Aspidosperma" is a genus of flowering plants in the family Apocynaceae, which are native to the Americas. These trees and shrubs are known for their milky sap and contain various alkaloids with potential medicinal properties. However, it's important to note that many of these compounds can also be toxic if not used properly. Therefore, "Aspidosperma" itself is not a medical term or treatment, but rather a botanical name for a group of plants. Any medicinal use of these plants should be done under the guidance of a qualified healthcare professional.
Indole alkaloids are a type of naturally occurring organic compound derived from the fusion of an indole ring, originating from tryptophan metabolism, with various other structures, often possessing significant biological activities such as anti-cancer, anti-malarial, and hallucinogenic properties.
Indole alkaloids are a type of naturally occurring organic compound that contain an indole structural unit, which is a heterocyclic aromatic ring system consisting of a benzene ring fused to a pyrrole ring. These compounds are produced by various plants and animals as secondary metabolites, and they have diverse biological activities. Some indole alkaloids have important pharmacological properties and are used in medicine as drugs or lead compounds for drug discovery. Examples of medically relevant indole alkaloids include reserpine, which is used to treat hypertension, and vinblastine and vincristine, which are used to treat various types of cancer.
Apocynaceae is a family of flowering plants that include species with milky sap, simple or compound leaves, and showy flowers, some of which contain cardiac glycosides and are used in traditional medicine and as ornamentals, such as oleander, periwinkle, and dogbane.
Apocynaceae is a family of flowering plants that includes shrubs, trees, and vines. It's also known as the dogbane or milkweed family. The plants in this family have milky sap and contain toxic compounds, which can be harmful or even fatal to animals and humans if ingested. Some well-known members of Apocynaceae include the various species of milkweeds (Asclepias spp.), oleander (Nerium oleander), and periwinkle (Vinca spp.).
The family is characterized by having opposite leaves, flowers with five petals and five sepals, and a superior ovary. The fruits are usually paired follicles that contain numerous seeds with tufts of hair to aid in wind dispersal. Many species in this family have medicinal or toxic properties, and some have economic importance as ornamental plants, sources of fiber, or for their use in traditional medicine.
Apocynaceae2
- Aspidosperma is a genus of flowering plant in the family Apocynaceae, first described as a genus in 1824. (wikipedia.org)
- This name is the accepted name of a species in the genus Aspidosperma (family Apocynaceae ). (plantlist.org)
Quebracho-blanco1
- White quebracho (Aspidosperma quebracho-blanco) is a common tree around Santiago del Estero The rustic tala (Celtis tala) is closely related to our native desert hackberry and another common tree almost everywhere Monk parakeets taking advantage of a dying red quebracho tree Roadkill on the way to Chaco province. (palmtalk.org)
White Quebracho1
- It is commonly known as Aspidosperma quebracho and White Quebracho. (plankhomeopathy.com)
Genus1
- This volume contains part of the Flora of Panama and a revision of the genus Aspidosperma, amongst other things. (theferns.info)
Excelsum2
- The light elastic wood of the Aspidosperma excelsum , a tree of Guiana having a fluted trunk readily split into planks. (wordnik.com)
- noun The light elastic wood of Aspidosperma excelsum, a South American tree whose trunk is readily split into planks . (wordnik.com)
Respiratory centers1
- As a remedy for organic heart disease, Aspidosperma addresses cardiac irritability, stimulates respiratory centers, and enhances oxygen levels in the blood. (plankhomeopathy.com)
Kuhlm1
- Aspidosperma compactinervium Kuhlm. (pfaf.org)
Homeopathy3
- A fake post including a video and written messages are circulating on social media claims that Homeopathy medicine Aspidosperma Q 20 can. (check4spam.com)
- Aspidosperma is one of the excellent remedies in homeopathy from the vegetable kingdom, mostly indicated in lung diseases. (plankhomeopathy.com)
- False post including a video, posters, and written messages are circulating on social media with claims that Homeopathy medicine Aspidosperma Q 20 can be taken as a substitute for oxygen when oxygen levels fall. (check4spam.com)
Alkaloid2
- It is the Aspidospermine alkaloid and its salts content of Aspidosperma which possess the medicinal effect when given in a crude form and is of great homeopathic therapeutic purpose when given in dynamic doses. (plankhomeopathy.com)
- Recycling upstream redox enzymes expands the regioselectivity of cycloaddition in Pseudo-Aspidosperma alkaloid biosynthesis. (mpg.de)
Markgr2
- Aspidosperma pruinosum Markgr. (pfaf.org)
- Aspidosperma snethlagei Markgr. (plantlist.org)
Oxygen Levels1
- Aspidosperma is one of the best remedies for respiratory paralysis, causing breathlessness, this remedy helps in improving the oxygen levels in the blood and saves the patient from going into a coma. (plankhomeopathy.com)
Asthma2
- Aspidosperma is a remarkable remedy for relieving asthma symptoms characterized by a livid face, difficulty breathing, and bluish discoloration of the lips, face, and fingertips. (plankhomeopathy.com)
- In cases of cardiac asthma, characterized by a feeling of breathlessness, Aspidosperma is among the top-listed remedies. (plankhomeopathy.com)
Tree2
Eyes1
- Aspidosperma is a beneficial remedy for iritis, a condition characterized by redness, irritation, and a burning sensation in the eyes. (plankhomeopathy.com)
Quebracho1
- Quebracho (Aspidosperma). (henriettes-herb.com)
Alkaloids2
- 2. Cytotoxic aspidosperma-type alkaloids from Melodinus suaveolens. (nih.gov)
- The developed strategy enables easily available lactams to be used as stable surrogates of multisubstituted amines and would be applicable to a unified total synthesis of complex Aspidosperma alkaloids. (elsevierpure.com)
Megalocarpon1
- Aspidosperma megalocarpon Müll. (fieldmuseum.org)
Mart1
- Aspidosperma Mart. (cybertaxonomy.org)
Synthesis1
- Their highly convergent synthesis features the regio- and diastereoselective Polonovski-Potier-type reaction for the coupling of two pentacyclic aspidosperma skeletons and the formation of the dihydrofuran ring. (chemistryviews.org)
Scientific1
- Meedan's team of public health experts provide scientific information on aspidosperma Q 20 and how it should not be seen as a treatment for abnormal oxygen levels, COVID-19, or any other medical condition. (ekta-facts.com)