The sebaceous glands situated on the inner surface of the eyelids between the tarsal plates and CONJUNCTIVA.
Eyelid diseases refer to various medical conditions that affect the function, structure, or appearance of the eyelids, including inflammatory, infectious, neoplastic, congenital, and traumatic disorders, which can impact vision, comfort, and overall ocular health.
Each of the upper and lower folds of SKIN which cover the EYE when closed.
The fluid secreted by the lacrimal glands. This fluid moistens the CONJUNCTIVA and CORNEA.
Inflammation of the eyelids.
Corneal and conjunctival dryness due to deficient tear production, predominantly in menopausal and post-menopausal women. Filamentary keratitis or erosion of the conjunctival and corneal epithelium may be caused by these disorders. Sensation of the presence of a foreign body in the eye and burning of the eyes may occur.
Small, sacculated organs found within the DERMIS. Each gland has a single duct that emerges from a cluster of oval alveoli. Each alveolus consists of a transparent BASEMENT MEMBRANE enclosing epithelial cells. The ducts from most sebaceous glands open into a HAIR FOLLICLE, but some open on the general surface of the SKIN. Sebaceous glands secrete SEBUM.
A plastic substance deposited by insects or obtained from plants. Waxes are esters of various fatty acids with higher, usually monohydric alcohols. The wax of pharmacy is principally yellow wax (beeswax), the material of which honeycomb is made. It consists chiefly of cerotic acid and myricin and is used in making ointments, cerates, etc. (Dorland, 27th ed)
The tear-forming and tear-conducting system which includes the lacrimal glands, eyelid margins, conjunctival sac, and the tear drainage system.
The oily substance secreted by SEBACEOUS GLANDS. It is composed of KERATIN, fat, and cellular debris.
Nerve fibers which project from parasympathetic ganglia to synapses on target organs. Parasympathetic postganglionic fibers use acetylcholine as transmitter. They may also release peptide cotransmitters.
The hairs which project from the edges of the EYELIDS.
Passage of light through body tissues or cavities for examination of internal structures.
The mucous membrane that covers the posterior surface of the eyelids and the anterior pericorneal surface of the eyeball.
Glands that secrete SALIVA in the MOUTH. There are three pairs of salivary glands (PAROTID GLAND; SUBLINGUAL GLAND; SUBMANDIBULAR GLAND).
Methods and procedures for the diagnosis of diseases of the eye or of vision disorders.
Measurement of light given off by fluorescein in order to assess the integrity of various ocular barriers. The method is used to investigate the blood-aqueous barrier, blood-retinal barrier, aqueous flow measurements, corneal endothelial permeability, and tear flow dynamics.
Nerve cells where transmission is mediated by NITRIC OXIDE.
That portion of the electromagnetic spectrum usually sensed as heat. Infrared wavelengths are longer than those of visible light, extending into the microwave frequencies. They are used therapeutically as heat, and also to warm food in restaurants.
"Esters are organic compounds that result from the reaction between an alcohol and a carboxylic acid, playing significant roles in various biological processes and often used in pharmaceutical synthesis."
Green dyes containing ammonium and aryl sulfonate moieties that facilitate the visualization of tissues, if given intravenously. They have mostly been used in the study of kidney physiology.

Identification of androgen receptor protein and 5alpha-reductase mRNA in human ocular tissues. (1/158)

BACKGROUND/AIMS: Androgens have been reported to influence the structural organisation, functional activity, and/or pathological features of many ocular tissues. In addition, these hormones have been proposed as a topical therapy for such conditions as dry eye syndromes, corneal wound healing, and high intraocular pressure. To advance our understanding of androgen action in the eye, the purpose of the present study was twofold: firstly, to determine whether tissues of the anterior and posterior segments contain androgen receptor protein, which might make them susceptible to hormone effects following topical application; and, secondly, to examine whether these tissues contain the mRNA for types 1 and/or 2 5alpha-reductase, an enzyme that converts testosterone to the very potent metabolite, dihydrotestosterone. METHODS: Human ocular tissues and cells were obtained and processed for histochemical and molecular biological procedures. Androgen receptor protein was identified by utilising specific immunoperoxidase techniques. The analysis of type 1 and type 2 5alpha-reductase mRNAs was performed by the use of RT-PCR, agarose gel electrophoresis, and DNA sequence analysis. All immunohistochemical evaluations and PCR amplifications included positive and negative controls. RESULTS: These findings show that androgen receptor protein exists in the human lacrimal gland, meibomian gland, cornea, bulbar and forniceal conjunctivae, lens epithelial cells, and retinal pigment epithelial cells. In addition, our results demonstrate that the mRNAs for types 1 and 2 5alpha-reductase occur in the human lacrimal gland, meibomian gland, bulbar conjunctiva, cornea, and RPE cells. CONCLUSION: These combined results indicate that multiple ocular tissues may be target sites for androgen action.  (+info)

Regulation of MMP-9 activity in human tear fluid and corneal epithelial culture supernatant. (2/158)

PURPOSE: To evaluate human corneal epithelial culture supernatant and tear fluid for the presence of activators and inhibitors of matrix metalloproteinase (MMP)-9, MMP-3, and tissue inhibitor of metalloproteinase (TIMP)-1, respectively, and to evaluate the effect of MMP-3 on the activation of MMP-9 in these specimens. METHODS: Unstimulated tear fluid was collected from patients with ocular rosacea and normal control subjects. Levels of MMP-9, MMP-3, and TIMP-1 were determined by enzyme-linked immunosorbent assay (ELISA) and/or immunoblot analysis. Supernatants from primary human corneal epithelial cultures and human tear fluid were incubated with MMP-3. Cultured epithelial cells and their supernatants were also treated with doxycycline before MMP-3 was added. Gelatin zymography was used to identify activated 82-kDa MMP-9. MMP-9 activity was assessed with a commercial MMP-9 activity assay system. RESULTS: MMP-9 and TIMP-1 were detected at significantly higher concentrations in rosacea-affected than in normal tear fluids. MMP-3 was detected exclusively in the tear fluid of patients with ocular rosacea who had corneal epithelial disease. Treatment of the supernatant and tear fluid with MMP-3 resulted in two bands with molecular weights of 92 kDa and 82 kDa, representing pro-MMP-9 and activated MMP-9, respectively. Doxycycline added to the conditioned media did not affect activation of MMP-9 by MMP-3. However, 24-hour treatment of corneal epithelial cultures with doxycycline resulted in a lower concentration and activity of MMP-9 in their supernatants. CONCLUSIONS: MMP-9 and TIMP-1 are produced by the human corneal epithelium and are present in tear fluid. MMP-3 alone is sufficient to activate MMP-9 on the ocular surface. Doxycycline does not directly inhibit this activation by MMP-3, but it decreases MMP-9 activity when added to corneal epithelial cultures.  (+info)

The instilled fluid dynamics and surface chemistry of polymers in the preocular tear film. (3/158)

Using slit lamp fluorophotometry it was demonstrated that the rate of drainage of a vehicle placed in the eye increased with increasing volume and that polymer solutions increased the thickness of the precorneal tear film (PTF). By increasing the viscosity of the delivery vehicle, (e.g., a hydroxypropylmethylcellulose polymer solutions), the PTF retention of fluorescein could be increased. The increased retention was shown to be due to an increase in the tear reservoir volume provided by the more viscous solutions. The PTF retention of fluorescein in a polyvinyl alcohol (PVA) vehicle was not as viscosity dependent, although PVA did seem to produce greater initial PTF fluorescence. This suggested that PVA initially produced a thicker PTF. The PTF retention of fluorescein by five commercial solutions did not have any relation to their wetting properties. The only good correlation with fluorescein retention in the PTF measured, seemed to be the ability of different polymer solutions to stabilize a thick layer of water as measured by the spontaneous spreading of polymer molecules at the air/liquid interface on wet glass surfaces. This model was designed to simulate tear film spreading in vivo. The results suggest that different polymer solutions may produce thicker PTF's than normal by virtue of their ability to drag water with them as they spread over the ocular surface with each blink. Mechanisms by which polymer solutions may increase the thickness of the PTF are discussed.  (+info)

Androgen influence on the meibomian gland. (4/158)

PURPOSE: The hypothesis in the study was that androgens control meibomian gland function, regulate the quality and/or quantity of lipids produced by this tissue, and promote the formation of the tear film's lipid layer. To test this hypothesis, a study was conducted to determine whether androgen receptor protein exists in the epithelial cell nuclei of rat meibomian glands and, in addition, whether androgen deficiency and/or treatment influences the gross morphology, neutral lipid content, and fatty acid profile of the rabbit meibomian gland, as well as the appearance of the tear film lipid layer. METHODS: Rat lids were obtained and processed for immunohistochemistry. Meibomian glands from intact, androgen- and/or placebo-treated rabbits were analyzed by histology, and glandular lipids were evaluated by gas chromatography, high-performance liquid chromatography (HPLC), and mass spectrometry. The rabbit tear film lipid layer was assessed by interferometry. RESULTS: In the current study androgen receptor protein existed within acinar epithelial cell nuclei of rat meibomian glands; androgen deficiency was associated with alterations in the lipid content of the rabbit meibomian gland; 19-nortestosterone treatment modulated the fatty acid profile in the total and neutral lipid fractions of the rabbit meibomian gland; and androgens did not appear to influence the gross morphology of meibomian tissue or to exert a demonstrable effect on the rabbit tear film lipid layer. CONCLUSIONS: The findings show that the meibomian gland is an androgen target organ and that androgens influence the lipid profile within this tissue. However, the extent to which androgens regulate the production of these lipids and whether this action may impact tear film stability remain to be determined.  (+info)

The SAFE strategy for the elimination of trachoma by 2020: will it work? (5/158)

WHO has recently launched a programme (GET 2020) for the elimination of trachoma, the leading cause of preventable blindness. GET 2020 has adopted the SAFE strategy, a comprehensive set of control measures (Surgery for entropion/trichiasis; Antibiotics for infectious trachoma; Facial cleanliness to reduce transmission; Environmental improvements such as control of disease-spreading flies and access to clean water). The present article reviews the strengths and weaknesses of each component of the strategy. Although significant hurdles remain to be overcome there is every reason to hope that GET 2020 will be successful.  (+info)

Polychlorinated biphenyls poisoning in monkey eye. (6/158)

Poisoning by polychlorinated biphenyl(s) (PCB) in humans leads to cutaneous and ocular findings. A white, cheeselike secretion issuing from the orifice of the Meibomian gland duct when the eyelid is squeezed is one sign of this intoxiation. In the rhesus monkey, abnormal hyperkeratosis of the ductal epithelium was observed histopathologically.  (+info)

15-Lipoxygenase-2 expression in benign and neoplastic sebaceous glands and other cutaneous adnexa. (7/158)

15-Lipoxygenase-2 has a limited tissue distribution in epithelial tissues, with mRNA detected in skin, cornea, lung, and prostate. It was originally cloned from human hair rootlets. In this study the distribution of 15-lipoxygenase-2 was characterized in human skin using immunohistochemistry and in situ hybridization. Strong uniform 15-lipoxygenase-2 in situ hybridization (n = 6) and immunostaining (n = 16) were observed in benign cutaneous sebaceous glands, with expression in differentiated secretory cells. Strong 15-lipoxygenase-2 immunostaining was also observed in secretory cells of apocrine and eccrine glands. Variable reduced immunostaining was observed in skin-derived sebaceous neoplasms (n = 8). In the eyelid, Meibomian glands were uniformly negative for 15-lipoxygenase-2 in all cases examined (n = 9), and sebaceous carcinomas apparently derived from Meibomian glands were also negative (n = 12). The mechanisms responsible for differential expression in cutaneous sebaceous vs eyelid Meibomian glands remain to be established. In epidermis, positive immunostaining was observed in the basal cell layer in normal skin, whereas five examined basal cell carcinomas were negative. Thus, the strongest 15-lipoxygenase-2 expression is in the androgen regulated secretory cells of sebaceous, apocrine, and eccrine glands. This compares with the prostate, in which 15-lipoxygenase-2 is expressed in differentiated prostate secretory cells (and reduced in the majority of prostate adenocarcinomas). The product of 15-lipoxygenase-2, 15-hydroxyeicosatetraenoic acid, may be a ligand for the nuclear receptor peroxisome proliferator activated receptor-gamma, which is expressed in sebocytes, and contribute to secretory differentiation in androgen regulated tissues such as prostate and sebaceous glands.  (+info)

Targeted disruption of stearoyl-CoA desaturase1 gene in mice causes atrophy of sebaceous and meibomian glands and depletion of wax esters in the eyelid. (8/158)

Stearoyl-CoA desaturase (SCD) is a microsomal rate-limiting enzyme in the cellular synthesis of monounsaturated fatty acids (MUFA), mainly oleate (18:1) and palmitoleate (16:1), which are the major MUFA of membrane phospholipids, cholesterol esters and triglycerides. Three well-characterized isoforms of SCD, SCD1, SCD2 and SCD3, exist in mice. To investigate the physiologic functions of SCD1, we generated SCD1 null (SCD1-/-) mice. The skin and eyelid of SCD1-/- mice are deficient in triglycerides and cholesterol esters, and the eyelid also is deficient in wax esters. Furthermore, the eyelid and skin of SCD1-/- mice have higher levels of free cholesterol. SCD1-/- mice develop cutaneous abnormalities and narrow eye fissure with atrophic sebaceous and meibomian glands. Consumption of diets containing high levels of oleate, failed to restore the levels of triglycerides, cholesterol esters and wax esters in SCD1-/- mice to the levels found in the eyelid of wild-type mice. These results reveal a physiologic role of SCD in cholesterol homeostasis as well as in the de novo biosynthesis of cholesterol esters, triglycerides and wax esters required for normal skin and eyelid function.  (+info)

Meibomian glands are sebaceous glands located in the eyelids, specifically at the rim of the eyelid near the lashes. They produce an oily substance called meibum that forms the outermost layer of the tear film, helping to prevent evaporation and keep the eye surface lubricated. The Meibomian glands play a crucial role in maintaining the health and comfort of the eyes by providing stability to the tear film and protecting the eye from irritants and dryness.

Eyelid diseases refer to a variety of medical conditions that affect the function and/or appearance of the eyelids. These can include structural abnormalities, such as entropion (inward turning of the eyelid) or ectropion (outward turning of the eyelid), as well as functional issues like ptosis (drooping of the upper eyelid). Other common eyelid diseases include blepharitis (inflammation of the eyelid margin), chalazion (a blocked oil gland in the eyelid), and cancerous or benign growths on the eyelid. Symptoms of eyelid diseases can vary widely, but often include redness, swelling, pain, itching, tearing, and sensitivity to light. Treatment for these conditions depends on the specific diagnosis and may range from self-care measures and medications to surgical intervention.

Eyelids are the thin folds of skin that cover and protect the front surface (cornea) of the eye when closed. They are composed of several layers, including the skin, muscle, connective tissue, and a mucous membrane called the conjunctiva. The upper and lower eyelids meet at the outer corner of the eye (lateral canthus) and the inner corner of the eye (medial canthus).

The main function of the eyelids is to protect the eye from foreign particles, light, and trauma. They also help to distribute tears evenly over the surface of the eye through blinking, which helps to keep the eye moist and healthy. Additionally, the eyelids play a role in facial expressions and non-verbal communication.

In medical terms, "tears" are a clear, salty liquid that is produced by the tear glands (lacrimal glands) in our eyes. They serve to keep the eyes moist, protect against dust and other foreign particles, and help to provide clear vision by maintaining a smooth surface on the front of the eye. Tears consist of water, oil, and mucus, which help to prevent evaporation and ensure that the tears spread evenly across the surface of the eye. Emotional or reflexive responses, such as crying or yawning, can also stimulate the production of tears.

Blepharitis is a common inflammatory condition that affects the eyelids, specifically the eyelash follicles and the edges of the eyelids (called the "eyelid margins"). It can cause symptoms such as redness, swelling, itching, burning, and a crusty or flaky buildup on the lashes. Blepharitis can be caused by a variety of factors, including bacterial infection, skin disorders like seborrheic dermatitis or rosacea, and meibomian gland dysfunction. It is often a chronic condition that requires ongoing treatment to manage symptoms and prevent recurrence.

Dry eye syndrome, also known as keratoconjunctivitis sicca, is a condition characterized by insufficient lubrication and moisture of the eyes. This occurs when the tears produced by the eyes are not sufficient in quantity or quality to keep the eyes moist and comfortable. The medical definition of dry eye syndromes includes the following symptoms:

1. A gritty or sandy sensation in the eyes
2. Burning or stinging sensations
3. Redness and irritation
4. Blurred vision that improves with blinking
5. Light sensitivity
6. A feeling of something foreign in the eye
7. Stringy mucus in or around the eyes
8. Difficulty wearing contact lenses
9. Watery eyes, which may seem contradictory but can be a response to dryness
10. Eye fatigue and discomfort after prolonged screen time or reading

The causes of dry eye syndromes can include aging, hormonal changes, certain medical conditions (such as diabetes, rheumatoid arthritis, lupus, Sjogren's syndrome), medications (antihistamines, decongestants, antidepressants, birth control pills), environmental factors (dry air, wind, smoke, dust), and prolonged screen time or reading.

Treatment for dry eye syndromes depends on the severity of the condition and its underlying causes. It may include artificial tears, lifestyle changes, prescription medications, and in some cases, surgical procedures to improve tear production or drainage.

Sebaceous glands are microscopic, exocrine glands that are found in the dermis of mammalian skin. They are attached to hair follicles and produce an oily substance called sebum, which is composed of triglycerides, wax esters, squalene, and metabolites of fat-producing cells (fatty acids, cholesterol). Sebum is released through a duct onto the surface of the skin, where it forms a protective barrier that helps to prevent water loss, keeps the skin and hair moisturized, and has antibacterial properties.

Sebaceous glands are distributed throughout the body, but they are most numerous on the face, scalp, and upper trunk. They can also be found in other areas of the body such as the eyelids (where they are known as meibomian glands), the external ear canal, and the genital area.

Abnormalities in sebaceous gland function can lead to various skin conditions, including acne, seborrheic dermatitis, and certain types of skin cancer.

I believe you may be asking for a medical explanation or examples of substances that are referred to as "waxes." Waxes are not a specific medical term, but they can refer to various natural or synthetic esters that are insoluble in water and have a soft, waxy consistency. In a medical context, the term "waxes" might refer to:

1. Cerumen (Earwax): A yellowish waxy substance produced by glands in the ear canal. Cerumen helps protect the ear by trapping dirt, dust, and other particles and preventing them from entering the inner ear.
2. Sebaceous Waxes: These are esters found in sebum, an oily substance produced by sebaceous glands in the skin. Sebum helps keep the skin and hair moisturized and protected.
3. Cutaneous Waxes: These are lipid-rich substances secreted by specialized sweat glands called eccrine glands. They help to waterproof and protect the skin.
4. Histological Waxes: Paraffin or other waxes used in histology for tissue processing, embedding, and microtomy to prepare thin sections of tissues for examination under a microscope.

These are some examples of substances that can be referred to as "waxes" in a medical context.

The lacrimal apparatus is a complex system in the eye that produces, stores, and drains tears. It consists of several components including:

1. Lacrimal glands: These are located in the upper outer part of the eyelid and produce tears to keep the eye surface moist and protected from external agents.
2. Tear ducts (lacrimal canaliculi): These are small tubes that drain tears from the surface of the eye into the lacrimal sac.
3. Lacrimal sac: This is a small pouch-like structure located in the inner part of the eyelid, which collects tears from the tear ducts and drains them into the nasolacrimal duct.
4. Nasolacrimal duct: This is a tube that runs from the lacrimal sac to the nose and drains tears into the nasal cavity.

The lacrimal apparatus helps maintain the health and comfort of the eye by keeping it lubricated, protecting it from infection, and removing any foreign particles or debris.

Sebum is an oily, waxy substance that is produced by the sebaceous glands in the skin of mammals. It is composed mainly of triglycerides, wax esters, squalene, and free fatty acids, as well as smaller amounts of metabolites and other substances. Sebum plays an important role in the maintenance of the skin's barrier function and in the regulation of its moisture levels. It also has antimicrobial properties that help to protect the skin from infection. Excessive sebum production can contribute to the development of acne and other skin conditions.

Parasympathetic fibers, postganglionic, refer to the portion of the parasympathetic nervous system's peripheral nerves that arise from ganglia (clusters of neurons) located near or within the target organs. These postganglionic fibers are responsible for transmitting signals from the ganglia to the effector organs such as glands, smooth muscles, and heart, instructing them to carry out specific functions.

The parasympathetic nervous system is one of the two subdivisions of the autonomic nervous system (the other being the sympathetic nervous system). Its primary role is to conserve energy and maintain homeostasis during rest or digestion. The preganglionic fibers originate in the brainstem and sacral spinal cord, synapsing in the ganglia located near or within the target organs. Upon receiving signals from the preganglionic fibers, the postganglionic fibers release neurotransmitters like acetylcholine to activate muscarinic receptors on the effector organ, leading to responses such as decreased heart rate, increased gastrointestinal motility and secretion, and contraction of the urinary bladder.

Eyelashes are defined in medical terms as the slender, hair-like growths that originate from the edges of the eyelids. They are made up of keratin and follicles, and their primary function is to protect the eyes from debris, sweat, and other irritants by acting as a physical barrier. Additionally, they play a role in enhancing the aesthetic appeal of the eyes and can also serve as a sensory organ, helping to detect potential threats near the eye area.

Transillumination is a medical procedure that involves the passage of bright light through a body structure, typically fluid-filled or hollow organs, to assess their size, location, or presence of abnormalities. This technique is often used to examine structures such as the breasts, lungs, or extremities in both adults and children. The transmission of light can help identify any irregularities like tumors, cysts, or other lesions based on the differences in light transmission through normal and abnormal tissues. It's a non-invasive, relatively simple, and quick method to gain preliminary information about certain medical conditions. However, transillumination is not commonly used as a primary diagnostic tool and often serves as an adjunct to other imaging techniques or clinical examinations.

The conjunctiva is the mucous membrane that lines the inner surface of the eyelids and covers the front part of the eye, also known as the sclera. It helps to keep the eye moist and protected from irritants. The conjunctiva can become inflamed or infected, leading to conditions such as conjunctivitis (pink eye).

Salivary glands are exocrine glands that produce saliva, which is secreted into the oral cavity to keep the mouth and throat moist, aid in digestion by initiating food breakdown, and help maintain dental health. There are three major pairs of salivary glands: the parotid glands located in the cheeks, the submandibular glands found beneath the jaw, and the sublingual glands situated under the tongue. Additionally, there are numerous minor salivary glands distributed throughout the oral cavity lining. These glands release their secretions through a system of ducts into the mouth.

Diagnostic techniques in ophthalmology refer to the various methods and tests used by eye specialists (ophthalmologists) to examine, evaluate, and diagnose conditions related to the eyes and visual system. Here are some commonly used diagnostic techniques:

1. Visual Acuity Testing: This is a basic test to measure the sharpness of a person's vision. It typically involves reading letters or numbers from an eye chart at a specific distance.
2. Refraction Test: This test helps determine the correct lens prescription for glasses or contact lenses by measuring how light is bent as it passes through the cornea and lens.
3. Slit Lamp Examination: A slit lamp is a microscope that allows an ophthalmologist to examine the structures of the eye, including the cornea, iris, lens, and retina, in great detail.
4. Tonometry: This test measures the pressure inside the eye (intraocular pressure) to detect conditions like glaucoma. Common methods include applanation tonometry and non-contact tonometry.
5. Retinal Imaging: Several techniques are used to capture images of the retina, including fundus photography, fluorescein angiography, and optical coherence tomography (OCT). These tests help diagnose conditions like macular degeneration, diabetic retinopathy, and retinal detachments.
6. Color Vision Testing: This test evaluates a person's ability to distinguish between different colors, which can help detect color vision deficiencies or neurological disorders affecting the visual pathway.
7. Visual Field Testing: This test measures a person's peripheral (or side) vision and can help diagnose conditions like glaucoma, optic nerve damage, or brain injuries.
8. Pupillary Reactions Tests: These tests evaluate how the pupils respond to light and near objects, which can provide information about the condition of the eye's internal structures and the nervous system.
9. Ocular Motility Testing: This test assesses eye movements and alignment, helping diagnose conditions like strabismus (crossed eyes) or nystagmus (involuntary eye movement).
10. Corneal Topography: This non-invasive imaging technique maps the curvature of the cornea, which can help detect irregularities, assess the fit of contact lenses, and plan refractive surgery procedures.

Fluorophotometry is a medical diagnostic technique that measures the concentration of fluorescein dye in various tissues, particularly the eye. This technique utilizes a specialized instrument called a fluorophotometer which emits light at a specific wavelength that causes the fluorescein to emit light at a longer wavelength. The intensity of this emitted light is then measured and used to calculate the concentration of fluorescein in the tissue.

Fluorophotometry is often used in ophthalmology to assess the permeability of the blood-retinal barrier, which can be helpful in diagnosing and monitoring conditions such as diabetic retinopathy, age-related macular degeneration, and uveitis. It may also have applications in other medical fields for measuring the concentration of fluorescent markers in various tissues.

Nitrergic neurons are specialized cells within the nervous system that release nitric oxide (NO) as their primary neurotransmitter. Nitric oxide is a small, gaseous molecule that plays an essential role in various physiological processes, including neurotransmission, vasodilation, and immune response.

In the context of the nervous system, nitrergic neurons are involved in several functions:

1. Neurotransmission: Nitric oxide acts as a retrograde messenger, transmitting signals backward across synapses to modulate the activity of presynaptic neurons. This unique mode of communication allows for fine-tuning of neural circuits and contributes to various cognitive processes, such as learning and memory.
2. Vasodilation: Nitrergic neurons are present in blood vessel walls, where they release nitric oxide to cause vasodilation. This process helps regulate blood flow and pressure in different organs and tissues.
3. Immune response: Nitrergic neurons can interact with immune cells, releasing nitric oxide to modulate their activity and contribute to the body's defense mechanisms.
4. Gastrointestinal motility: In the gastrointestinal tract, nitrergic neurons are involved in regulating smooth muscle contractility and relaxation, which influences gut motility and secretion.
5. Reproductive system function: Nitrergic neurons play a role in the regulation of sexual behavior, penile erection, and sperm motility in the male reproductive system.

It is important to note that nitrergic neurons can be found throughout the nervous system, including the central and peripheral nervous systems, and are involved in various physiological processes. Dysfunction of these neurons has been implicated in several pathological conditions, such as neurodegenerative diseases, cardiovascular disorders, and gastrointestinal motility dysfunctions.

Infrared rays are not typically considered in the context of medical definitions. They are a type of electromagnetic radiation with longer wavelengths than those of visible light, ranging from 700 nanometers to 1 millimeter. In the field of medicine, infrared radiation is sometimes used in therapeutic settings for its heat properties, such as in infrared saunas or infrared therapy devices. However, infrared rays themselves are not a medical condition or diagnosis.

Esters are organic compounds that are formed by the reaction between an alcohol and a carboxylic acid. They are widely found in nature and are used in various industries, including the production of perfumes, flavors, and pharmaceuticals. In the context of medical definitions, esters may be mentioned in relation to their use as excipients in medications or in discussions of organic chemistry and biochemistry. Esters can also be found in various natural substances such as fats and oils, which are triesters of glycerol and fatty acids.

Lissamine Green Dyes are a type of diagnostic dye used in ophthalmology to assess the health and integrity of the tear film and the corneal surface. These dyes have a green color and are often used in conjunction with other dyes like fluorescein. When applied to the eye, Lissamine Green Dyes selectively stain areas of the eye that have been damaged or disrupted, such as areas of dryness, irritation, or inflammation.

The dye binds to denatured proteins and cellular debris on the surface of the eye, highlighting any abnormalities in the tear film or corneal epithelium. Lissamine Green Dyes can help diagnose conditions such as dry eye syndrome, exposure keratopathy, and corneal abrasions. The dye is generally considered safe for use in diagnostic procedures, but it should be used with caution and according to proper protocols to minimize any potential risks or discomfort to the patient.

A blocked meibomian gland can cause a chalazion (or "meibomian cyst") to form in the eyelid. Meibomian gland dysfunction Gland ... Meibomian glands (also called tarsal glands, palpebral glands, and tarsoconjunctival glands) are sebaceous glands along the ... Meibomian gland probing is also used on patients who experience deep clogging of the glands. Meibomian gland dysfunction may be ... Inflammation of the meibomian glands (also known as meibomitis, meibomian gland dysfunction, or posterior blepharitis) causes ...
What are meibomian glands?. Meibomian glands are the oil glands that line the edge of your eyelids, near your eyelashes. Around ... What is meibomian gland dysfunction?. Meibomian gland dysfunction (MGD) is a common condition that occurs when the meibomian ... usually as a result of a blockage in the meibomian glands at the base of the eyelashes. When meibomian glands do not produce ... Meibomian gland dysfunction can cause significant ocular discomfort and dry eyes, but can be effectively treated if detected ...
Evaluation of Meibomian Gland Dysfunction Among Ophthalmic Healthcare Workers ...
It is characterised by obstruction of the Meibomian glands and/or alterations in the consistency of glandular secretions. At ... Meibomian gland dysfunction (MGD) is frequently encountered by eye care practitioners. ... Meibomian gland dysfunction (MGD) is frequently encountered by eye care practitioners. It is characterised by obstruction of ... Intense pulsed light for the treatment of Meibomian gland dysfunction: A systematic review and meta-analysis.. Aug 10, 2020 ...
Learn how to manage Meibomian Gland Dysfunction (MGD) and Dry Eye with the latest treatments and techniques. Get the facts on ... Meibomian gland dysfunction (MGD) is a common eye condition that affects the meibomian glands, which are located in the eyelids ... One of the most common causes of dry eye is meibomian gland dysfunction (MGD). MGD is a condition in which the meibomian glands ... and meibomian gland expression, can be used to reduce symptoms and improve the health of the meibomian glands. By managing MGD ...
Meibomian Gland Dysfunction (MGD). MGD causes blockages in the meibomian glands which prevents them from secreting enough oil, ... a larger problem found within the glands of the eyelids. Meibomian glands are tiny glands found in our eyelids and they are ... Treating the leading cause of Dry Eye: MGD (Meibomian Gland Dysfunction). For many suffering from Dry Eye, the underlying cause ... This application has proved to be an extremely effective process for clearing blockages found in the Meibomian glands. Best of ...
Meibomian Gland Dysfunction is a blockage of your meibomian gland, which are located in the lower and upper eyelids near the ... LipiFlow® may help provide relief by removing the blockage of the Meibomian Glands. When the glands are properly function this ... What Do You Know About Meibomian Gland Dysfunction?. November 1, 2014. August 26, 2014. Dr. Brian 0 Comment Dry Eye Dry Eye, ... Meibomian Gland Dysfunction is one such cause of dry eyes and can cause inflammation of the eye and eyelid. ...
Tips for optometrists on coding for meibomian gland disease and Keratoconjunctivitis Sicca including codes to use. ... H02.88A Meibomian Gland Dysfunction Right Eye, Upper and Lower Eyelids. H02.88B Meibomian Gland Dysfunction Left Eye, Upper and ... NOT Meibomian Gland Dysfunction) therefore it should not be listed in the modifying factors for Meibomian Gland Dysfunction. ... Evacuation of meibomian glands, using heat delivered through wearable, open-eye eyelid treatment devices and manual gland ...
Association Between Contact Lens Discomfort and Meibomian Gland Morphology. Contact Lens & Anterior Eye. ... Association of Ocular Surface and Meibomian Gland Alterations With Silicone Hydrogel Contact Lens Wear Cont Lens Anterior Eye ... Is contact lens discomfort related to meibomian gland morphology?. Cont Lens Anterior Eye 2022 Aug 23;[EPub Ahead of Print], M ... Epiphora Outcomes Following Surgery for Meibomian Gland Inversion in Patients With Facial Nerve Palsy Ophthalmic Plast Reconstr ...
Growth factor influence on immortalized meibomian gland epithelial cells * Meibomian gland epithelial cells differentiating in ... Meibomian glands of subjects with moderate to severe gland dysfunction * The influence of retinoic acid on immortalized human ... Influence of video display terminal use and meibomian gland dysfunction on the ocular surface and te… ... Antibiotic treatment for dry eye disease related to meibomian gland dysfunction and blepharitis - A … ...
Meibomian Gland Expression . Ensure your health and wellbeing using Private Medical Services offered by Dr Arun Ghosh at our ... What Is Meibomian Gland Expression?. Meibomian Gland Expression is a procedure performed to cure MGD (Meibomian Gland ... There are about 25 to 40 Meibomian glands in the upper eyelid and 20 to 30 in the lower eyelid. The function of these glands is ... Meibomian Gland Dysfunction is usually found in adults over 45 years of age. It has many causes, from environmental stress, ...
The prevalence of meibomian gland dysfunction ranges from 30.3% to 63.3% and, in Asia, the prevalence is at the top of that ... Because severe meibomian gland dysfunction can alter the lid margin structure, confounding efforts to assess outcomes, only ... In their study, Dr Jain and his team recruited 60 patients with moderate signs and symptoms of meibomian gland dysfunction who ... Over the study period, improvement was seen in all measures of meibomian gland dysfunction in the two groups, except the ...
... and how to unclog meibomian glands naturally and through treatments here at Pacific Pier Optometry in Santa Monica, CA. ... What Meibomian Glands Are & How They Work Meibomian glands are oil glands situated along the edge of your eyelids at the base ... Causes of Clogged Meibomian Glands Clogged meibomian glands can be quite a nuisance, causing dry, irritated eyes. There are ... it can lead to meibomian gland dysfunction (MGD). In MGD, the meibomian glands dont secrete enough oil. This can cause the ...
THE MEIBOMIAN GLANDS. LITTLE WHITE BUMPS EXPLAINED! Meibomian glands are modified sebaceous glands that are… ...
Meibomian gland dysfunction (MGD) is a common eye condition that occurs when the Meibomian glands in the eyelids do not ... It used to be that imaging of these Meibomian glands would reveal short, missing, or clogged glands for many patients in their ... In a recent study, 42% of kids aged 4 to 17 years showed some evidence of Meibomian gland atrophy. We do not have direct ... Unfortunately, we cant cure dry eyes, but we do have good therapies that can help to keep these Meibomian glands healthy and ...
Everything you need to know about Meibomian Gland Lipogranuloma. Health Issue Description - FCN ... A chalazion is a cyst in the eyelid that is caused by inflammation of a blocked meibomian gland, usually on the upper eyelid. ... The condition is caused by obstruction of one of the ducts that drains one of the Meibomian glands. ...
So why do I claim that Dry Eye Disease IS Meibomian Gland Dysfunction? Clinically, Meibomian Gland Dysfunction is super ... Meibomian Gland Dysfunction has caused a tear imbalance leading to dry eye but the initial cause was Meibomian Gland ... the lacrimal gland as well as the meibomian glands and theres other accessory glands that produce tears as well. ... Meibomian glands are sebaceous glands located all along both your upper and lower eyelids. They play an important role in ...
... Alpha-1 blocker therapy for BPH may be the culprit, study suggests.. By ... Morphological Changes of Meibomian Glands in Men With Benign Prostate Hyperplasia. Cornea 2021;40:445-448. ... Between previous studies showing BPH as a risk factor for dry eye disease (DED), meibomian gland dysfunction (MGD) being the ... reflecting loss of meibomian glands. Tear breakup time was significantly shorter (3.6 vs. 5.6 seconds), and Schirmer score was ...
Meibomian gland dysfunction, or MGD, is a common type of eye condition. Its name refers to the gland located in the eyelids ... Dry eye often occurs as a result of the Meibomian gland becoming blocked. Other abnormalities in the glands size, location, ... and shape can also trigger blockage or dysfunction of the gland. This leads to dry eye and is called Meibomian gland ... Meibomian Gland Dysfunction: Let Our Lancaster Optometrist Help You. When you visit our Lancaster optometrist, a key part of ...
Centre for Ocular Research & Education. School of Optometry & Vision Science. University of Waterloo. 200 University Avenue West. Waterloo, ON, Canada N2L 3G1. P: +1-519-888-4742. P: +1-519-888-4303. [email protected]. ...
Because of this, his zeis, moll and meibomian glands have burnt up and he no longer has lubrication in his eyes. He is in pain ... What Are Treatment Options for Loss of Zeis, Moll and Meibomian Glands Due to Stevens-Johnson Syndrome/TEN?. November 10, 2010 ... One Response to "What Are Treatment Options for Loss of Zeis, Moll and Meibomian Glands Due to Stevens-Johnson Syndrome/TEN?" ... How can he be helped? Is there any type of surgeries out there that can replace these glands? Please let me know. Thanks much! ...
TFOS treatment videos: Debridement, Lid hygiene, Lid warming, punctual plugging and therapeutic meibomian gland expression. TBA ...
After examining the meibomian glands you find, in addition to the keratinization, a severe dropout of the lower lid glands ( ... Since the literature has shown that over 84% of dry eye is the result of meibomian gland dysfunction (MGD), you perform a quick ... De-capping or opening meibomian gland orifices,. *Massaging or sonic stimulation of the lid margin mechanically breaking up ... When treating meibomian gland (MGD) is critical. 03/18/22, 9:56 am ...
Meibomian gland dysfunction is a condition when the meibomian glands cant produce enough meibum to keep the ocular surfaces ... Meibomian Gland Dysfunction. Meibomian Gland Dysfunction is basically a blockage in the meibomian glands due to which they fail ... Symptoms Of Meibomian Gland Dysfunction. The major symptoms of the meibomian gland dysfunction includes:. Dryness:. The eyes ... Causes Of Meibomian Gland Dysfunction. Meibomian gland dysfunction can be the result of a number of causes. The most common ...
Learn about all about Meibomian Gland Dysfunction: the causes, symptoms and treatment options. ...
Learn about all about Meibomian Gland Dysfunction: the causes, symptoms and treatment options. ... What are the Solutions for Meibomian Gland Dysfunction?. Treatments for Meibomian Gland Dysfunction range from self- ... Meibomian Gland Dysfunction occurs when the meibomian glands fail to provide enough meibum. This can be triggered by various ... What is Meibomian Gland Dysfunction?. Our tears are made up of three components: the lipid (oil) layer, aqueous (water) layer, ...
Meibomian gland dysfunction is part of this issue. ...
Learn about all about Meibomian Gland Dysfunction: the causes, symptoms and treatment options. ...
Meibomian Gland Probing and Expression (MGPE). Intraductal meibomian gland probing is a relatively nontraumatic method to ... Meibomian Gland Expression takes 20 minutes and it is safe for you to drive home after treatment. ... A specially designed tool unblocks each of the meibomian glands and expresses the build-up of oil. A topical antibiotic/steroid ... As we use a topical anaesthesia (eyedrops), Meibomian Gland Expression is not painful and almost all patients tolerate the ...

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