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Osteonecrosis: Death of a bone or part of a bone, either atraumatic or posttraumatic.Femur Head Necrosis: Aseptic or avascular necrosis of the femoral head. The major types are idiopathic (primary), as a complication of fractures or dislocations, and LEGG-CALVE-PERTHES DISEASE.Bisphosphonate-Associated Osteonecrosis of the Jaw: Necrotic jaws or other maxillofacial skeleton necrosis associated with bisphosphonate use (see BISPHOSPHONATES). Injury, dental procedures, and trauma can trigger the necrotic process.Jaw DiseasesFemur Head: The hemispheric articular surface at the upper extremity of the thigh bone. (Stedman, 26th ed)Diphosphonates: Organic compounds which contain P-C-P bonds, where P stands for phosphonates or phosphonic acids. These compounds affect calcium metabolism. They inhibit ectopic calcification and slow down bone resorption and bone turnover. Technetium complexes of diphosphonates have been used successfully as bone scanning agents.Bone Density Conservation Agents: Agents that inhibit BONE RESORPTION and/or favor BONE MINERALIZATION and BONE REGENERATION. They are used to heal BONE FRACTURES and to treat METABOLIC BONE DISEASES such as OSTEOPOROSIS.Jaw: Bony structure of the mouth that holds the teeth. It consists of the MANDIBLE and the MAXILLA.Maxillary DiseasesHumerus: Bone in humans and primates extending from the SHOULDER JOINT to the ELBOW JOINT.Methylprednisolone: A PREDNISOLONE derivative with similar anti-inflammatory action.Hip Joint: The joint that is formed by the articulation of the head of FEMUR and the ACETABULUM of the PELVIS.Mandibular DiseasesTooth Extraction: The surgical removal of a tooth. (Dorland, 28th ed)Metal-on-Metal Joint Prostheses: Types of prosthetic joints in which both wear surfaces of the joint coupling are metallic.Bone Transplantation: The grafting of bone from a donor site to a recipient site.Glucocorticoids: A group of CORTICOSTEROIDS that affect carbohydrate metabolism (GLUCONEOGENESIS, liver glycogen deposition, elevation of BLOOD SUGAR), inhibit ADRENOCORTICOTROPIC HORMONE secretion, and possess pronounced anti-inflammatory activity. They also play a role in fat and protein metabolism, maintenance of arterial blood pressure, alteration of the connective tissue response to injury, reduction in the number of circulating lymphocytes, and functioning of the central nervous system.Osteocytes: Mature osteoblasts that have become embedded in the BONE MATRIX. They occupy a small cavity, called lacuna, in the matrix and are connected to adjacent osteocytes via protoplasmic projections called canaliculi.Femur: The longest and largest bone of the skeleton, it is situated between the hip and the knee.Fibula: The bone of the lower leg lateral to and smaller than the tibia. In proportion to its length, it is the most slender of the long bones.Alendronate: A nonhormonal medication for the treatment of postmenopausal osteoporosis in women. This drug builds healthy bone, restoring some of the bone loss as a result of osteoporosis.Osteotomy: The surgical cutting of a bone. (Dorland, 28th ed)Orthopedic Procedures: Procedures used to treat and correct deformities, diseases, and injuries to the MUSCULOSKELETAL SYSTEM, its articulations, and associated structures.Dromaiidae: A family of flightless, running BIRDS, in the order Casuariiformes. The emu is the only surviving member of the family. They naturally inhabit forests, open plains, and grasslands in Australia.Dental Prophylaxis: Treatment for the prevention of periodontal diseases or other dental diseases by the cleaning of the teeth in the dental office using the procedures of DENTAL SCALING and DENTAL POLISHING. The treatment may include plaque detection, removal of supra- and subgingival plaque and calculus, application of caries-preventing agents, checking of restorations and prostheses and correcting overhanging margins and proximal contours of restorations, and checking for signs of food impaction.Blood Coagulation Disorders, Inherited: Hemorrhagic and thrombotic disorders that occur as a consequence of inherited abnormalities in blood coagulation.Arthroplasty, Replacement, Hip: Replacement of the hip joint.Epiphyses: The head of a long bone that is separated from the shaft by the epiphyseal plate until bone growth stops. At that time, the plate disappears and the head and shaft are united.Femoral Neck Fractures: Fractures of the short, constricted portion of the thigh bone between the femur head and the trochanters. It excludes intertrochanteric fractures which are HIP FRACTURES.Magnetic Resonance Imaging: Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.Imidazoles: Compounds containing 1,3-diazole, a five membered aromatic ring containing two nitrogen atoms separated by one of the carbons. Chemically reduced ones include IMIDAZOLINES and IMIDAZOLIDINES. Distinguish from 1,2-diazole (PYRAZOLES).Decompression, Surgical: A surgical operation for the relief of pressure in a body compartment or on a body part. (From Dorland, 28th ed)Pulsed Radiofrequency Treatment: The application, via IMPLANTED ELECTRODES, of short bursts of electrical energy in the radiofrequency range, interspersed with pauses in delivery of the current long enough to dissipate the generated heat and avoid heat-induced tissue necrosis.Adrenal Cortex HormonesTantalum: Tantalum. A rare metallic element, atomic number 73, atomic weight 180.948, symbol Ta. It is a noncorrosive and malleable metal that has been used for plates or disks to replace cranial defects, for wire sutures, and for making prosthetic devices. (Dorland, 28th ed)Osteoradionecrosis: Necrosis of bone following radiation injury.Hip: The projecting part on each side of the body, formed by the side of the pelvis and the top portion of the femur.Knee Joint: A synovial hinge connection formed between the bones of the FEMUR; TIBIA; and PATELLA.Hip Dislocation, Congenital: Congenital dislocation of the hip generally includes subluxation of the femoral head, acetabular dysplasia, and complete dislocation of the femoral head from the true acetabulum. This condition occurs in approximately 1 in 1000 live births and is more common in females than in males.Retrospective Studies: Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.Tooth Socket: A hollow part of the alveolar process of the MAXILLA or MANDIBLE where each tooth fits and is attached via the periodontal ligament.Hip Prosthesis: Replacement for a hip joint.Ilium: The largest of three bones that make up each half of the pelvic girdle.Osteoarthritis, Hip: Noninflammatory degenerative disease of the hip joint which usually appears in late middle or old age. It is characterized by growth or maturational disturbances in the femoral neck and head, as well as acetabular dysplasia. A dominant symptom is pain on weight-bearing or motion.Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Bone Remodeling: The continuous turnover of BONE MATRIX and mineral that involves first an increase in BONE RESORPTION (osteoclastic activity) and later, reactive BONE FORMATION (osteoblastic activity). The process of bone remodeling takes place in the adult skeleton at discrete foci. The process ensures the mechanical integrity of the skeleton throughout life and plays an important role in calcium HOMEOSTASIS. An imbalance in the regulation of bone remodeling's two contrasting events, bone resorption and bone formation, results in many of the metabolic bone diseases, such as OSTEOPOROSIS.Magnetic Field Therapy: The magnetic stimulation of specific target tissues or areas of the body for therapeutic purposes via the application of magnetic fields generated by MAGNETS or ELECTROMAGNETS.Dexamethasone: An anti-inflammatory 9-fluoro-glucocorticoid.Prosthesis Failure: Malfunction of implantation shunts, valves, etc., and prosthesis loosening, migration, and breaking.Range of Motion, Articular: The distance and direction to which a bone joint can be extended. Range of motion is a function of the condition of the joints, muscles, and connective tissues involved. Joint flexibility can be improved through appropriate MUSCLE STRETCHING EXERCISES.Follow-Up Studies: Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.Bone Regeneration: Renewal or repair of lost bone tissue. It excludes BONY CALLUS formed after BONE FRACTURES but not yet replaced by hard bone.Arthroplasty: Surgical reconstruction of a joint to relieve pain or restore motion.Mandible: The largest and strongest bone of the FACE constituting the lower jaw. It supports the lower teeth.Technetium Tc 99m Medronate: A gamma-emitting radionuclide imaging agent used primarily in skeletal scintigraphy. Because of its absorption by a variety of tumors, it is useful for the detection of neoplasms.Reoperation: A repeat operation for the same condition in the same patient due to disease progression or recurrence, or as followup to failed previous surgery.Oral Surgical Procedures: Surgical procedures used to treat disease, injuries, and defects of the oral and maxillofacial region.Time Factors: Elements of limited time intervals, contributing to particular results or situations.Risk Factors: An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.Arthralgia: Pain in the joint.

*  Mitochondrial stress and redox failure in steroid-associated osteonecrosis
The definition of osteonecrosis used in this model was based on that of Yamamoto et al. Namely osteonecrosis was considered to ... B) MP14 group ((A), (B)×200). Osteonecrosis was not found in any of the animals in either C group. In MP14 group, osteonecrosis ... When osteonecrosis was noted in either femur, osteonecrosis was defined as present in that sample. ... Suehiro M, Hirano T, Mihara K, Shindo H. Etiologic factors in femoral head osteonecrosis in growing rats. J Ortop Sci. 2000;5(1 ...
http://www.medsci.org/v15p0205.htm
*  Patient specific surgical guide design and application in preoperative planning for femoral head necrosis using computer aided...
Volumetric analysis of osteonecrosis of the femur. Anatomical correlation using MRI. J Bone Joint Surg Br 2001; 83: 672-675. ... Volumetric measurement of osteonecrosis of the femoral head using computerized MR and primary mechanical test. Chin J Radiol ... Yin S, Zhang C, Jin D, Chen S, Sun Y. Treatment of osteonecrosis of the femoral head in lymphoma patients by free vascularised ... Non-traumatic osteonecrosis of the femoral head: ten years later. J Bone Joint Surg Am 2006; 88: 1117-1132. ...
http://www.alliedacademies.org/articles/patient-specific-surgical-guide-design-and-application-in-preoperative-planning-for-femoral-head-necrosis-using-computer-aided-des.html
*  Bisphosphonate-associated osteonecrosis of the jaw - Wikipedia
... a term for osteonecrosis caused by radiotherapy Nase JB, Suzuki JB (August 2006). "Osteonecrosis of the jaw and oral ... Bisphosphonate-associated osteonecrosis of the jaw (BON, BONJ) is death of the jawbone in a person with a history of ... Osteonecrosis, or localized death of bone tissue, of the jaws is a rare potential complication in cancer patients receiving ... The treatment the person receives depends on the severity of osteonecrosis of the jaw. Indicated in patients who have evidence ...
https://en.wikipedia.org/wiki/Bisphosphonate-associated_osteonecrosis_of_the_jaw
*  Osteonecrosis of the Jaw
Managing osteonecrosis of the jaw. Osteonecrosis of the jaw is usually treated with antibiotics, oral rinses, and removable ... Osteonecrosis of the jaw is a rare but serious condition in which the cells in the jawbone start to die. ... Because osteonecrosis of the jaw is rare, doctors can't predict who will develop it. If you're taking a bisphosphonate, tell ... Tips to minimize your risk for osteonecrosis of the jaw:. * Schedule a dental exam and cleaning before you being breast cancer ...
https://www.breastcancer.org/treatment/side_effects/osteonecrosis
*  Osteonecrosis | bone tissue death | Britannica.com
Osteonecrosis, death of bone tissue that may result from infection, as in osteomyelitis, or deprivation of blood supply, as in ... called necrosis of bone or osteonecrosis. Osteonecrosis may be caused by injury to blood vessels, associated with dislocation ... More About Osteonecrosis. 1 reference found in Britannica articles. Assorted References. *major reference* In bone disease: ... Osteonecrosis, also called necrosis of bone, death of bone tissue that may result from infection, as in osteomyelitis, or ...
https://www.britannica.com/science/osteonecrosis
*  Dysbaric osteonecrosis - Wikipedia
ischemic bone disease caused by decompression bubbles Dysbaric osteonecrosis or DON is a form of avascular necrosis where there ... ISBN 0-7020-2571-2. Coulthard, A; Pooley, J; Reed J; Walder, D (1996). "Pathophysiology of dysbaric osteonecrosis: a magnetic ... permanent dead link] Wade, CE; Hayashi, EM; Cashman, TM; Beckman, EL (1978). "Incidence of dysbaric osteonecrosis in Hawaii's ... Evidence does not suggest that dysbaric osteonecrosis is a significant risk in recreational scuba diving. Treatment is ...
https://en.wikipedia.org/wiki/Dysbaric_osteonecrosis
*  Osteonecrosis of the jaw related to sunitinib | SpringerLink
Schwartz HC (1982) Osteonecrosis of the jaws: a complication of cancer chemotherapy. Head Neck Surg 4:251-253CrossRefPubMed ... Prevalence of bisphosphonate associated osteonecrosis of the jaw within the field of osteonecrosis. Support Care Cancer 15:197- ... Osteonecrosis Sunitinib Multi-kinase inhibitor Side effect Tooth extraction Cancer therapy This is a preview of subscription ... Assael LA (2004) New foundations in understanding osteonecrosis of the jaws. J Oral Maxillofac Surg 62:125-126CrossRefPubMed ...
https://link.springer.com/article/10.1007%2Fs10006-010-0224-y
*  Neuralgia-inducing cavitational osteonecrosis - Wikipedia
Neuralgia-inducing cavitational osteonecrosis (NICO) is a controversial diagnosis whereby a putative jawbone cavitation causes ... Also called Ratner's bone cavity, a neuralgia-inducing cavitational osteonecrosis was first described in dental literature by G ... "AAE Position Statement on NICO lesions (Neuralgia-Inducing Cavitational Osteonecrosis)" (PDF). AAE Research and Scientific ... Zuniga JR (September 2000). "Challenging the neuralgia-inducing cavitational osteonecrosis concept". J. Oral Maxillofac. Surg. ...
https://en.wikipedia.org/wiki/Neuralgia-inducing_cavitational_osteonecrosis
*  Osteonecrosis of the jaw - Wikipedia
Osteonecrosis of the jaw (ONJ) is a severe bone disease (osteonecrosis) that affects the jaws (the maxilla and the mandible). ... "Osteonecrosis of the Jaw". Novartis. Bouquot J; Wrobleski G; Fenton S (2000). "The most common osteonecrosis? Prevalence of ... in both non-traumatic osteonecrosis and alcohol-induced osteonecrosis of the femoral head, a decrease in the differentiation ... Osteonecrosis can affect any bone, but the hips, knees and jaws are most often involved. Pain can often be severe, especially ...
https://en.wikipedia.org/wiki/Osteonecrosis_of_the_jaw
*  ACTH protects against glucocorticoid-induced osteonecrosis of bone | PNAS
2003) Osteonecrosis of the femoral head of laboratory animals: The lessons learned from a comparative study of osteonecrosis in ... ACTH protects against glucocorticoid-induced osteonecrosis of bone. Mone Zaidi, Li Sun, Lisa J. Robinson, Irina L. Tourkova, Li ... ACTH protects against glucocorticoid-induced osteonecrosis of bone. Mone Zaidi, Li Sun, Lisa J. Robinson, Irina L. Tourkova, Li ... osteonecrosis, usually affecting the femoral head (1). Osteonecrosis almost invariably requires surgical debridement of dead ...
https://www.pnas.org/content/107/19/8782
*  Osteonecrosis of all Major Joints | RIAO
Osteonecrosis of the hip is a well-described entity in which a portion of the hip wall loses its blood supply and thus the bone ... Osteonecrosis of all Major Joints Osteonecrosis. Osteonecrosis of the hip is a well-described entity in which a portion of the ... Hip osteonecrosis is felt to be associated with approximately 10% of all hip replacements done in this country, the majority of ... As the osteonecrosis (AVN) progresses, the area of necrosis may collapse and arthritis may ensue. Physical findings are also ...
http://www.lifebridgehealth.org/RIAO/OsteonecrosisofallMajorJoints.aspx
*  Osteonecrosis of the jaw: Leukaemia Foundation
Osteonecrosis of the jaw (ONJ) is a rare condition, the cause of which is not entirely known. It involves the loss or breakdown ... Osteonecrosis of the jaw. Osteonecrosis of the jaw (ONJ) is a rare condition, the cause of which is not entirely known. It ... To diagnose osteonecrosis of the jaw, doctors may use X-rays or other radiology. Treatments for osteonecrosis of the jaw may ... The bones of the jaw seem to be particularly prone to osteonecrosis. In the mouth, the bone is only covered by a small layer of ...
http://www.leukaemia.org.au/blood-cancers/myeloma/osteonecrosis-of-the-jaw/osteonecrosis-of-the-jaw
*  Osteonecrosis - Merck Manuals Professional Edition
Merck & Co., Inc., Kenilworth, NJ, USA is a global healthcare leader working to help the world be well. From developing new therapies that treat and prevent disease to helping people in need, we are committed to improving health and well-being around the world. The Merck Manual was first published in 1899 as a service to the community. The legacy of this great resource continues as the Merck Manual in the US and Canada and the MSD Manual in the remainder of the world. Learn more about our commitment to Global Medical Knowledge.. ...
http://www.merckmanuals.com/en-ca/professional/musculoskeletal-and-connective-tissue-disorders/osteonecrosis
*  Spontaneous osteonecrosis of the knee - Wikipedia
Avascular necrosis Osteonecrosis of the jaw Dysbaric osteonecrosis "Spontaneous osteonecrosis of the knee". Radiopaedia.org. ... Spontaneous osteonecrosis of the Knee, also known as Ahlback's disease is the result of vascular arterial insufficiency to the ... Ecker, Ml; Lotke, Pa (May 1994). "Spontaneous Osteonecrosis of the Knee". The Journal of the American Academy of Orthopaedic ... Kattapuram, Tm; Kattapuram, Sv (July 2008). "Spontaneous osteonecrosis of the knee". 67 (1): 42-8. doi:10.1016/j.ejrad.2008.01. ...
https://en.wikipedia.org/wiki/Spontaneous_osteonecrosis_of_the_knee
*  Osteonecrosis (Bone Infarction) Imaging: Practice Essentials, Radiography, Computed Tomography
Osteonecrosis secondary to Cushing disease. Osteonecrosis secondary to Cushing disease occurs as a result of excess levels of ... encoded search term (Osteonecrosis (Bone Infarction) Imaging) and Osteonecrosis (Bone Infarction) Imaging What to Read Next on ... Spontaneous osteonecrosis. Spontaneous osteonecrosis around the adult knee (ie, Ahlbäck disease) is a distinct clinical entity ... Posttraumatic osteonecrosis. Posttraumatic osteonecrosis usually follows a fracture; most cases occur in areas with vulnerable ...
https://emedicine.medscape.com/article/387545-overview
*  Understanding Osteonecrosis of the Jaw
What Is Osteonecrosis of the Jaw?. Osteonecrosis of the jaw (ONJ) is a severe bone disease that occurs when the jawbone is ... Bisphosphonates and osteonecrosis of the jaw: Proceedings of an international conference. Annals of the New York Academy of ...
http://news.cancerconnect.com/understanding-osteonecrosis-of-the-jaw/
*  Osteonecrosis - Pipeline Review, H2 2017
H2 2017 Osteonecrosis - Pipeline Review, H2 2017 Summary Global Markets Direct's latest Pharmaceutical and Healthcare disease ... pipeline guide Osteonecrosis - Pipeline Review, - Market research report and industry analysis - 11296578 ... Osteonecrosis - Pipeline by Enzo Biochem Inc, H2 2017 Osteonecrosis - Pipeline by K-Stemcell Co Ltd, H2 2017 Osteonecrosis - ... Osteonecrosis - Overview Osteonecrosis - Therapeutics Development Pipeline Overview Pipeline by Companies Products under ...
https://www.marketresearch.com/Global-Markets-Direct-v3480/Osteonecrosis-Pipeline-Review-H2-11296578/
*  Progressive Diffuse Osteonecrosis in a Patient with Secondary Hemophagocytic Lymphohistiocytosis
Similarly, the extent of osteonecrosis was thought to be rather atypically diffuse for just steroid related osteonecrosis, ... of osteonecrosis with worsening pelvic bone osteonecrosis and new imaging findings of diffuse lumbar spine osteonecrosis. A ... Osteonecrosis of the pelvic bone was confirmed by bone marrow biopsy and involvement of the other bones assumed based on the ... M. F. Dilisio, "Osteonecrosis following short-term, low-dose oral corticosteroids: a population-based study of 24 million ...
https://www.hindawi.com/journals/crira/2015/730719/
*  What does osteonecrosis mean?
Meaning of osteonecrosis. What does osteonecrosis mean? Information and translations of osteonecrosis in the most comprehensive ... Definition of osteonecrosis in the Definitions.net dictionary. ... Search for osteonecrosis on Amazon. *Search for osteonecrosis ... What does osteonecrosis mean?. Definitions for osteonecrosis. Here are all the possible meanings and translations of the word ... Discuss these osteonecrosis definitions with the community:. Word of the Day. Would you like us to send you a FREE new word ...
https://www.definitions.net/definition/osteonecrosis
*  Disabilty from Avascular necrosis/ osteonecrosis - Osteoarthritis - HealingWell.com Forum
Inflammatory osteoarthritis; osteonecrosis from steroids. Grave's disease successfully treated with radioactive iodine and now ... HealingWell.com Forum , Diseases & Conditions , Osteoarthritis , Disabilty from Avascular necrosis/ osteonecrosis Select A ...
https://www.healingwell.com/community/default.aspx?f=51&m=2279237
*  Fosamax Osteonecrosis Side Effects
View Osteonecrosis Fosamax side effect risks. Female, 81 years of age, was diagnosed with osteoporosis and took Fosamax 70 Mg, ... Is Osteonecrosis a common side effect of Fosamax? ... Nerve Injury, Osteonecrosis, Osteonecrosis Of Jaw, Pain, Foot ... Fosamax Osteonecrosis Side Effect Reports. Home → Fosamax → Osteonecrosis The following Fosamax Osteonecrosis side effect ... Osteonecrosis, Ear Infection This Osteonecrosis side effect was reported by a physician from SE. A 74-year-old female patient ( ...
http://patientsville.com/fosamax/osteonecrosis.htm
*  Lexomil Osteonecrosis Side Effects
View Osteonecrosis Lexomil side effect risks. Male, 71 years of age, weighting 145.5 lb, was diagnosed with multiple myeloma ... Is Osteonecrosis a common side effect of Lexomil? ... Lexomil Osteonecrosis Causes and Reviews Osteonecrosis is a ... Lexomil Osteonecrosis Side Effect Reports. Home → Lexomil → Osteonecrosis The following Lexomil Osteonecrosis side effect ... Dental Care, Impaired Healing, Osteonecrosis, Tooth Extraction This Osteonecrosis Lexomil side effect was reported by a ...
http://patientsville.com/lexomil/osteonecrosis.htm
*  Solupred Osteonecrosis Side Effects
View Osteonecrosis Solupred side effect risks. Female, 74 years of age, weighting 138.9 lb, was diagnosed with multiple myeloma ... Is Osteonecrosis a common side effect of Solupred? ... Solupred Osteonecrosis Causes and Reviews Osteonecrosis is a ... Solupred Osteonecrosis Side Effect Reports. Home → Solupred → Osteonecrosis The following Solupred Osteonecrosis side effect ... Osteonecrosis, Wound Debridement This Osteonecrosis side effect was reported by a consumer or non-health professional from . A ...
http://patientsville.com/solupred/osteonecrosis.htm
*  Osteonecrosis more common in men than women in Korea
Men are much more prone to osteonecrosis ― a disease resulting from the loss of blood supply to the bones ― than women in South ... Men are much more prone to osteonecrosis ― a disease resulting from the loss of blood supply to the bones ― than women in South ... Men are much more prone to osteonecrosis than women in South Korea, according to a study organized by a state-run insurance ... The health expenditures from osteonecrosis totaled 38.2 billion won ($37.6 million) in 2007 and increased to 46.3 billion won ...
http://www.koreaherald.com/view.php?ud=20140828001083
*  Bisphosphonate-Related Osteonecrosis of the Jaw: Background, History of the Procedure, Epidemiology
Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a condition found in patients who have received intravenous and oral forms of bisphosphonate therapy for various bone-related conditions. Bisphosphonate-related osteonecrosis of the jaw (BRONJ) manifests as exposed, nonvital bone involving the maxillofacial structures.
http://emedicine.medscape.com/article/1447355-overview

*  Alendronic acid
Osteonecrosis of the jaw (deterioration of the temporomandibular joint or TMJ) may occur while on this drug, if dental work of ... "A review of the literature on osteonecrosis of the jaw in patients with osteoporosis treated with oral bisphosphonates: ... "Multiple systemic diseases complicated by bisphosphonate osteonecrosis: a case report". Ann Stomatol (Roma). 3 (2 Suppl): 32-6 ...
*  Bisphosphonate-associated osteonecrosis of the jaw
... a term for osteonecrosis caused by radiotherapy Nase JB, Suzuki JB (August 2006). "Osteonecrosis of the jaw and oral ... Bisphosphonate-associated osteonecrosis of the jaw (BON, BONJ) is death of the jawbone in a person with a history of ... Osteonecrosis, or localized death of bone tissue, of the jaws is a rare potential complication in cancer patients receiving ... The treatment the person receives depends on the severity of osteonecrosis of the jaw. Indicated in patients who have evidence ...
*  Dysbaric osteonecrosis
ischemic bone disease caused by decompression bubbles Dysbaric osteonecrosis or DON is a form of avascular necrosis where there ... ISBN 0-7020-2571-2. Coulthard, A; Pooley, J; Reed J; Walder, D (1996). "Pathophysiology of dysbaric osteonecrosis: a magnetic ... permanent dead link] Wade, CE; Hayashi, EM; Cashman, TM; Beckman, EL (1978). "Incidence of dysbaric osteonecrosis in Hawaii's ... Evidence does not suggest that dysbaric osteonecrosis is a significant risk in recreational scuba diving. Treatment is ...
*  Neuralgia-inducing cavitational osteonecrosis
... (NICO) is a controversial diagnosis whereby a putative jawbone cavitation causes ... Also called Ratner's bone cavity, a neuralgia-inducing cavitational osteonecrosis was first described in dental literature by G ... "AAE Position Statement on NICO lesions (Neuralgia-Inducing Cavitational Osteonecrosis)" (PDF). AAE Research and Scientific ... Zuniga JR (September 2000). "Challenging the neuralgia-inducing cavitational osteonecrosis concept". J. Oral Maxillofac. Surg. ...
*  Osteonecrosis of the jaw
... (ONJ) is a severe bone disease (osteonecrosis) that affects the jaws (the maxilla and the mandible). ... "Osteonecrosis of the Jaw". Novartis. Bouquot J; Wrobleski G; Fenton S (2000). "The most common osteonecrosis? Prevalence of ... in both non-traumatic osteonecrosis and alcohol-induced osteonecrosis of the femoral head, a decrease in the differentiation ... Osteonecrosis can affect any bone, but the hips, knees and jaws are most often involved. Pain can often be severe, especially ...
*  Spontaneous osteonecrosis of the knee
Avascular necrosis Osteonecrosis of the jaw Dysbaric osteonecrosis "Spontaneous osteonecrosis of the knee". Radiopaedia.org. ... Spontaneous osteonecrosis of the Knee, also known as Ahlback's disease is the result of vascular arterial insufficiency to the ... Ecker, Ml; Lotke, Pa (May 1994). "Spontaneous Osteonecrosis of the Knee". The Journal of the American Academy of Orthopaedic ... Kattapuram, Tm; Kattapuram, Sv (July 2008). "Spontaneous osteonecrosis of the knee". 67 (1): 42-8. doi:10.1016/j.ejrad.2008.01. ...
*  DMOZ - Health: Conditions and Diseases: Musculoskeletal Disorders: Osteonecrosis
Internet forum for osteonecrosis (also called avascular necrosis) offering information and support. ...
*  Avascular necrosis
Underwater diving portal Osteonecrosis / Avascular Necrosis at the National Institute of Health Osteonecrosis / Avascular ... Osteonecrosis is also associated with cancer, lupus, sickle cell disease, HIV infection, Gaucher's disease, and Caisson disease ... Digiovanni, Cw; Patel, A; Calfee, R; Nickisch, F (Apr 2007). "Osteonecrosis in the foot". The Journal of the American Academy ... Avascular necrosis (AVN), also called osteonecrosis or bone infarction, is death of bone tissue due to interruption of the ...
*  Index of oral health and dental articles
Osteonecrosis of the jaw • Osteoporotic bone marrow defect • Our Lady of Fatima University • Outer enamel epithelium • Painless ...
*  Infarction
Digiovanni, CW; Patel, A; Calfee, R; Nickisch, F (2007). "Osteonecrosis in the foot". The Journal of the American Academy of ...
*  Phossy jaw
Osteonecrosis of the jaw Bisphosphonate-associated osteonecrosis of the jaw Industrial injury Radium jaw "Workshops of Horror ... Phossy jaw Durie BG, Katz M, Crowley J (July 2005). "Osteonecrosis of the jaw and bisphosphonates". N. Engl. J. Med. 353 (1): ... A related condition, bisphosphonate-associated osteonecrosis of the jaw (BON), has been described as a side-effect of amino- ... Bis-phossy jaws' - High and low risk factors for bisphosphonate-induced osteonecrosis of the jaw". Department of Oral and ...
*  C-terminal telopeptide
Osteonecrosis of the jaws associated with the use of bisphosphonates: A review of 63 cases. J Oral Maxillofac Surg 2004;62:527 ... Bisphosphonate-related Osteonecrosis of the Jaws. Compendium 2008;29(2):97-105. Ju, H, et al. Comparison of analytical ... In order to evaluate the risk of osteonecrosis for a patient taking bisphosphonates, use of the CTX biomarker was introduced in ... Oral Bisphosphonate-Induced Osteonecrosis: Risk Factors, Prediction of Risk Using Serum CTX Testing, Prevention, and Treatment ...
*  Saturation diving
The joints are most vulnerable to osteonecrosis. The connection between high-pressure exposure and osteonecrosis is not fully ... ISBN 0-7020-2571-2. Coulthard, A.; Pooley, J.; Reed, J.; Walder, D. (1996). "Pathophysiology of dysbaric osteonecrosis: a ...
*  Atypical facial pain
Osteonecrosis of the jaws refers to the death of bone marrow in the maxilla or the mandible due to inadequate blood supply. It ... Neuralgia-inducing cavitational osteonecrosis (NICO) is a controversial term, and it is questioned to exist by many. ... The term NICO is used to describe pain caused by ischemic osteonecrosis of the jaws, where degenerative extracellular cystic ... Vogt-Ferrier, NB; Hugentobler M; Uebelhart B; Tramèr M; Rollason V (16 Jun 2010). "Interventions for treating osteonecrosis of ...
*  Ankle replacement
... substantial osteoporosis or osteonecrosis particularly affecting the talus; previous or current infections of the foot; ...
*  Adrenocorticotropic hormone
"ACTH protects against glucocorticoid-induced osteonecrosis of bone". Proceedings of the National Academy of Sciences of the ...
*  Crescent sign
Kenzora, J. E.; Glimcher, M. J. (1985). "Pathogenesis of idiopathic osteonecrosis: The ubiquitous crescent sign". The ...
*  Osteoblast
ACTH protects against glucocorticoid-induced osteonecrosis of bone. Proc Natl Acad Sci U S A. 2010 107:8782-7. doi:10.1073/pnas ...
*  Dentinogenesis imperfecta
2007). "Bisphosphonate associated osteonecrosis of the jaw: report of a task force of the American Society for Bone and Mineral ... A recognized risk of this drug relevant to dental treatments is bisphosphonate-associated osteonecrosis of the jaw (BRONJ). ... bisphosphonates and osteonecrosis of the jaws". Ann Intern Med. 144: 753-761. CS1 maint: Multiple names: authors list (link) ...
*  Pamidronic acid
Osteonecrosis of the jaw is a rare complication which has been associated with the use of bisphosphonates, including ... Zarychanski R, Elphee E, Walton P, Johnston J (2006). "Osteonecrosis of the jaw associated with pamidronate therapy". Am J ...
*  Daniel Ivankovich
Ivankovich DA; Rosenberg AG; Malamis A. (2001). "Reconstructive options for osteonecrosis of the femoral head". 16. Techniques ... Ivankovich completed additional fellowship training in adult joint reconstruction, with research emphasis on osteonecrosis and ...
*  Efavirenz/lamivudine/tenofovir
Severe side effects may include depression, psychosis, or osteonecrosis. In those with a history of epilepsy, it may increase ...
*  Bisphosphonate
Woo S, Hellstein J, Kalmar J (2006). "Narrative [corrected] review: bisphosphonates and osteonecrosis of the jaws". Ann Intern ... Bisphosphonates, when administered intravenously for the treatment of cancer, have been associated with osteonecrosis of the ...
*  Mandibular fracture
Rarely they may be due to osteonecrosis or tumors in the bone. The most common area of fracture is at the condyle (36%), body ( ... Cysts and tumours can limit effective bone to bone contact and osteomyelitis or osteonecrosis compromise blood supply to the ... where there is an area of osteomyelitis or where osteonecrosis exist cause special challenges to fixation and healing. ...
*  Surface-supplied diving
Long term diving disorders include dysbaric osteonecrosis, which is associated with decompression sickness. These disorders are ...

(1/476) Total knee replacement: should it be cemented or hybrid?

OBJECTIVE: To compare the complication rates associated with total knee arthroplasty against the types of fixation (hybrid or cemented), using a single total knee design (the anatomic modular knee [AMK] prosthesis). DESIGN: A prospective, nonrandomized, controlled trial. SETTING: University Hospital in London, Ont., a tertiary care teaching centre. PATIENTS: Two groups made up of 484 knees in 395 patients (89 bilateral). INTERVENTIONS: In 260 knees a hybrid configuration (cemented tibia and noncemented femur) was used (group 1). In 224 knees the femoral and tibial components were cemented (group 2). All patellae were cemented in both groups. MAIN OUTCOME MEASURES: Clinical results were assessed by The Knee Society Clinical Rating Scores at 3 months, 6 months and yearly intervals. Radiographic results were determined by 3-foot standing radiographs and at each follow-up visit standing knee radiographs, lateral and skyline views. Radiographs were analysed for alignment, presence or absence of radiolucent lines or changes in the position of the implant. All reoperations and nonoperative complications were recorded. RESULTS: At an average follow-up of 4.8 years, 8 knees (1.6%) required reoperation. An analysis of the complications leading to reoperation demonstrated no difference between the 2 groups. CONCLUSIONS: There was no difference in outcome whether the femoral component was cemented or not. Medium-term results of the AMK are excellent with a very low reoperation rate.  (+info)

(2/476) Osteonecrosis of the hip in sickle-cell disease associated with tuberculous arthritis. A review of 15 cases.

We report a study of 15 cases of tuberculous hips with sickle-cell disease who presented during 1991-1993. Although the osteonecrosis was long-standing, biopsy was nearly always required to reveal the more recent tuberculous infection. Management consisted of 6 months of anti-tuberculous chemotherapy with appropriate palliative surgery 5-8 weeks after the start of drug treatment. The operative techniques which we used are described. The results were good both post-operatively, and in 12 patients followed-up at an average of 3 years. We recommend this combined management for the treatment of secondary tuberculous infections of hips previously damaged by sickle-cell disease.  (+info)

(3/476) Disseminated thrombosis and bone infarction in female rats following inhalation exposure to 2-butoxyethanol.

Groups of 10 male and 10 female F344/N rats were exposed to 0, 31, 62.5, 125, 250, and 500 ppm of 2-butoxyethanol (BE) by inhalation, 6 hr/day, 5 days/wk, for 13 wk. Four moribund female rats from the 500 ppm group were sacrificed during the first 4 days of exposure, and 1 moribund female from the same group was sacrificed during week 5. Dark irregular mottling and/or loss of the distal tail were noted in sacrificed moribund rats. Similar gross lesions were noted in the terminally sacrificed females exposed to 500 ppm BE. Histologic changes noted in the day 4 sacrificed moribund rats included disseminated thrombosis involving the coccygeal vertebrae, cardiac atrium, lungs, liver, pulp of the incisor teeth, and the submucosa of the anterior section of the nasal cavity. Alterations noted in coccygeal vertebrae from the 500 ppm sacrificed moribund rats included ischemic necrosis and/or degeneration of bone marrow cells, bone-lining cells, osteocytes (within cortical and trabecular bone), and chondrocytes (both articular and growth plate), changes that are consistent with an infarction process. The moribund female rat that was sacrificed during week 5 and those female rats treated with 500 ppm and sacrificed following 13 wk of treatment lacked thrombi, but they had coccygeal vertebral changes consistent with prior infarction and transient or complete bone growth arrest. No bone lesions or thrombi were noted in the male rats treated with the same doses of BE. In conclusion, exposure to 500 ppm BE vapors caused acute disseminated thrombosis and bone infarction in female rats. Possible pathogenic mechanisms are discussed.  (+info)

(4/476) Treatment of autoimmune premature ovarian failure.

There is no known immunosuppressive therapy for autoimmune premature ovarian failure that has been proven safe and effective by prospective randomized placebo-controlled study. Nevertheless, immunosuppression using corticosteroids has been used on an empirical basis for this condition. Here we present two cases of young women with premature ovarian failure who were treated with glucocorticoids in the hopes of restoring fertility. The first case illustrates the potential benefit of such therapy, and the second case illustrates a potential risk. The first patient with histologically proven autoimmune oophoritis was treated with alternate day glucocorticoid treatment. She had return of menstrual bleeding six times and ovulatory progesterone concentrations four times over a 16 week period. The second patient with presumed but unconfirmed autoimmune ovarian failure was referred to us after having been treated with a 9 month course of corticosteroids. During that treatment her menses did not resume. The corticosteroid treatment was complicated by iatrogenic Cushing syndrome and osteonecrosis of the knee. Identifying patients with autoimmune premature ovarian failure presents the opportunity to restore ovarian function by treating these patients with the proper immune modulation therapy. On the other hand, potent immune modulation therapy can have major complications. Corticosteroid therapy for autoimmune premature ovarian failure should be limited to use in placebo-controlled trials designed to evaluate the safety and efficacy of such treatment.  (+info)

(5/476) Fat conversion of femoral marrow in glucocorticoid-treated patients: a cross-sectional and longitudinal study with magnetic resonance imaging.

OBJECTIVE: To study the changes in hematopoietic marrow in patients given glucocorticoid (steroid) therapy. METHODS: In a cross-sectional study, high-resolution T1-weighted magnetic resonance imaging (MRI) images of the proximal femur were obtained in an unselected series of 29 premenopausal female patients with systemic lupus erythematosus (SLE) and in a series of 29 age-matched healthy female subjects. In a longitudinal analysis, 2 MRI studies were performed 19 months apart in 11 patients with SLE (including 9 patients from the cross-sectional study who were evaluated before treatment) and in 7 patients with rheumatoid arthritis (RA). The percentage of fat marrow and the index of marrow conversion (IMC) were derived from the MRI images to estimate the degree of transformation of hematopoietic into fatty marrow in the area of the femoral neck. Values observed in the cross-sectional study and their changes over time were correlated with treatment data. RESULTS: The cross-sectional study performed in SLE patients indicated that their mean (+/- SD) percentage of fat marrow (48+/-36%) and IMC (82+/-12) were significantly more elevated than those in the healthy control subjects (18+/-16% and 75+/-6, respectively) (P<0.01). The magnitude of fat conversion correlated positively with the mean daily dose of oral prednisolone, and was higher in patients with ischemic bone lesions. The longitudinal study performed in SLE and RA patients revealed that IMC changes over time correlated positively with daily prednisolone intake (r = 0.71; P = 0.001), fat conversion occurring exclusively in patients receiving a mean prednisolone dose < or =7.5 mg/day. CONCLUSION: MRI indicates that fat conversion occurs in the proximal femur of steroid-treated patients. The magnitude of fat conversion correlates with steroid intake and is higher in patients with ischemic bone lesions.  (+info)

(6/476) Unusual complications in an inflammatory abdominal aortic aneurysm.

An unusual case of an inflammatory abdominal aortic aneurysm (IAAA) associated with coronary aneurysms and pathological fracture of the adjacent lumbar vertebrae. The associated coronary lesions in cases of IAAA are usually occlusions. In the present case, it was concluded that a possible cause of the coronary aneurysm was coronary arteritis and the etiology of the pathological fracture of the lumbar vertebrae was occlusion of the lumbar penetrating arteries due to vasculitis resulting in aseptic necrosis. Inflammatory AAA can be associated with aneurysms in addition to occlusive disease in systemic arteries. The preoperative evaluation of systemic arterial lesions and the function of systemic organs is essential.  (+info)

(7/476) Subchondral insufficiency fracture of the femoral head: a differential diagnosis in acute onset of coxarthrosis in the elderly.

OBJECTIVE: To document subchondral insufficiency fracture (SIF) of the femoral head and investigate its frequency. METHODS: The study was based on a retrospective review of 464 removed femoral heads (from 419 patients) with both radiologic and histologic evidence of subchondral collapse. Gross photographs, specimen radiographs, and histologic sections were reevaluated in all cases. Available clinical notes and imaging studies were also reviewed. RESULTS: Ten cases previously diagnosed as osteonecrosis were reinterpreted as SIF on a histopathologic basis. All of these patients were women over 65 years old (average age 75) with osteopenia. The initial symptom was acute onset of hip pain. Radiologically, a subchondral collapse, mainly in the superolateral segment of the femoral head, was noted. Magnetic resonance imaging, available in 3 cases, showed diffuse low intensity on T1-weighted images and high intensity on T2-weighted or fat-suppressed images. Bone scintigraphy, available in 4 cases, showed increased uptake in the femoral head. Histopathologically, a 1.0-2.5-cm long linear whitish gray zone, comprising fracture callus and granulation tissue, was found beneath the subchondral bone end plate. There was no evidence of antecedent osteonecrosis. CONCLUSION: The results of this study indicate that SIF should be included in the differential diagnosis of acute onset of coxarthrosis in the elderly.  (+info)

(8/476) Use of magnetic resonance imaging to diagnose common wrist disorders.

Magnetic resonance imaging is being used more frequently to diagnose and plan treatment of wrist disorders. This article reviews the common pathologic lesions of the wrist: avascular necrosis, triangular fibrocartilage complex tears, ligamentous tears, ganglion cysts, carpal tunnel syndrome, and osteoarthritis. The typical magnetic resonance imaging characteristics of these lesions is discussed.  (+info)


  • treatment
  • Once steroid-associated osteonecrosis develops it becomes refractory to treatment, and when the femoral head is crushed severe coxalgia and disturbed ambulation become major issues affecting patient quality of life. (medsci.org)
  • femoral head
  • We report that adrenocorticotropic hormone (ACTH) protects against osteonecrosis of the femoral head induced by depot methylprednisolone acetate (depomedrol). (pnas.org)
  • The use of glucocorticoids for medical conditions as diverse as asthma, ulcerative colitis, kidney diseases, and rheumatologic disorders causes not only a variety of metabolic and medical complications, including diabetes and osteoporosis, but also a painful debilitating condition, osteonecrosis, usually affecting the femoral head ( 1 ). (pnas.org)
  • For osteonecrosis of the femoral head, MRI has become the imaging modality of choice because of its high sensitivity and specificity. (medscape.com)
  • secondary
  • This is a case report of a patient who had been diagnosed with secondary hemophagocytic lymphohistiocytosis and received high dose corticosteroid, IVIG, and cyclosporine as treatment with serial imaging showing progressive osteonecrosis in bone marrow involving the spine, pelvis, hips, and shoulders. (hindawi.com)
  • Side Effects
  • Location: BE , 75 years of age, patient began experiencing various side effects, including: Directly after treatment started, patient experienced the unwanted or unexpected Fosamax side effects: osteonecrosis. (patientsville.com)
  • Treatment
  • Brunello A, Saia G, Bedogni A, Scaglione D, Basso U (2009) Worsening of osteonecrosis of the jaw during treatment with sunitinib in a patient with metastatic renal cell carcinoma. (springer.com)
  • Research
  • Ivankovich completed additional fellowship training in adult joint reconstruction, with research emphasis on osteonecrosis and hip replacement in medically co-morbid populations. (wikipedia.org)
  • blood
  • The humeral head receives its blood supply from intricate anastomoses originally branching off the axillary artery, which likely explains the relatively low rate of osteonecrosis compared to other articulations, such as the hip. (oncologynurseadvisor.com)