Adrenocortical Carcinoma: A malignant neoplasm of the ADRENAL CORTEX. Adrenocortical carcinomas are unencapsulated anaplastic (ANAPLASIA) masses sometimes exceeding 20 cm or 200 g. They are more likely to be functional than nonfunctional, and produce ADRENAL CORTEX HORMONES that may result in hypercortisolism (CUSHING SYNDROME); HYPERALDOSTERONISM; and/or VIRILISM.Adrenal Cortex Neoplasms: Tumors or cancers of the ADRENAL CORTEX.Mitotane: A derivative of the insecticide DICHLORODIPHENYLDICHLOROETHANE that specifically inhibits cells of the adrenal cortex and their production of hormones. It is used to treat adrenocortical tumors and causes CNS damage, but no bone marrow depression.Adrenocortical Adenoma: A benign neoplasm of the ADRENAL CORTEX. It is characterized by a well-defined nodular lesion, usually less than 2.5 cm. Most adrenocortical adenomas are nonfunctional. The functional ones are yellow and contain LIPIDS. Depending on the cell type or cortical zone involved, they may produce ALDOSTERONE; HYDROCORTISONE; DEHYDROEPIANDROSTERONE; and/or ANDROSTENEDIONE.Adrenal Cortex: The outer layer of the adrenal gland. It is derived from MESODERM and comprised of three zones (outer ZONA GLOMERULOSA, middle ZONA FASCICULATA, and inner ZONA RETICULARIS) with each producing various steroids preferentially, such as ALDOSTERONE; HYDROCORTISONE; DEHYDROEPIANDROSTERONE; and ANDROSTENEDIONE. Adrenal cortex function is regulated by pituitary ADRENOCORTICOTROPIN.Carcinoma: A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm but is often wrongly used as a synonym for "cancer." (From Dorland, 27th ed)Cushing Syndrome: A condition caused by prolonged exposure to excess levels of cortisol (HYDROCORTISONE) or other GLUCOCORTICOIDS from endogenous or exogenous sources. It is characterized by upper body OBESITY; OSTEOPOROSIS; HYPERTENSION; DIABETES MELLITUS; HIRSUTISM; AMENORRHEA; and excess body fluid. Endogenous Cushing syndrome or spontaneous hypercortisolism is divided into two groups, those due to an excess of ADRENOCORTICOTROPIN and those that are ACTH-independent.Adrenal Gland Neoplasms: Tumors or cancer of the ADRENAL GLANDS.Adrenocorticotropic Hormone: An anterior pituitary hormone that stimulates the ADRENAL CORTEX and its production of CORTICOSTEROIDS. ACTH is a 39-amino acid polypeptide of which the N-terminal 24-amino acid segment is identical in all species and contains the adrenocorticotrophic activity. Upon further tissue-specific processing, ACTH can yield ALPHA-MSH and corticotrophin-like intermediate lobe peptide (CLIP).Hydrocortisone: The main glucocorticoid secreted by the ADRENAL CORTEX. Its synthetic counterpart is used, either as an injection or topically, in the treatment of inflammation, allergy, collagen diseases, asthma, adrenocortical deficiency, shock, and some neoplastic conditions.Myelolipoma: A rare benign tumor of the adrenal gland, several centimeters in diameter, composed in varying proportions of adipose tissue, lymphocytes, and primitive myeloid cells, probably a developmental abnormality. (Dorland, 27th ed)Adrenal Glands: A pair of glands located at the cranial pole of each of the two KIDNEYS. Each adrenal gland is composed of two distinct endocrine tissues with separate embryonic origins, the ADRENAL CORTEX producing STEROIDS and the ADRENAL MEDULLA producing NEUROTRANSMITTERS.Adrenal Rest Tumor: Neoplasm derived from displaced cells (rest cells) of the primordial ADRENAL GLANDS, generally in patients with CONGENITAL ADRENAL HYPERPLASIA. Adrenal rest tumors have been identified in TESTES; LIVER; and other tissues. They are dependent on ADRENOCORTICOTROPIN for growth and adrenal steroid secretion.Adrenalectomy: Excision of one or both adrenal glands. (From Dorland, 28th ed)Steroid 17-alpha-Hydroxylase: A microsomal cytochrome P450 enzyme that catalyzes the 17-alpha-hydroxylation of progesterone or pregnenolone and subsequent cleavage of the residual two carbons at C17 in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP17 gene, generates precursors for glucocorticoid, androgen, and estrogen synthesis. Defects in CYP17 gene cause congenital adrenal hyperplasia (ADRENAL HYPERPLASIA, CONGENITAL) and abnormal sexual differentiation.Carcinoma, Squamous Cell: A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed)Adrenal Cortex Diseases: Pathological processes of the ADRENAL CORTEX.Carcinoma, Hepatocellular: A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.Adenoma: A benign epithelial tumor with a glandular organization.Feminization: Development of female secondary SEX CHARACTERISTICS in the MALE. It is due to the effects of estrogenic metabolites of precursors from endogenous or exogenous sources, such as ADRENAL GLANDS or therapeutic drugs.Adrenocortical Hyperfunction: Excess production of ADRENAL CORTEX HORMONES such as ALDOSTERONE; HYDROCORTISONE; DEHYDROEPIANDROSTERONE; and/or ANDROSTENEDIONE. Hyperadrenal syndromes include CUSHING SYNDROME; HYPERALDOSTERONISM; and VIRILISM.17-Ketosteroids: Steroids that contain a ketone group at position 17.17-alpha-Hydroxyprogesterone: A metabolite of PROGESTERONE with a hydroxyl group at the 17-alpha position. It serves as an intermediate in the biosynthesis of HYDROCORTISONE and GONADAL STEROID HORMONES.Li-Fraumeni Syndrome: Rare autosomal dominant syndrome characterized by mesenchymal and epithelial neoplasms at multiple sites. MUTATION of the p53 tumor suppressor gene, a component of the DNA DAMAGE response pathway, apparently predisposes family members who inherit it to develop certain cancers. The spectrum of cancers in the syndrome was shown to include, in addition to BREAST CANCER and soft tissue sarcomas (SARCOMA); BRAIN TUMORS; OSTEOSARCOMA; LEUKEMIA; and ADRENOCORTICAL CARCINOMA.Endocrine Surgical Procedures: Surgery performed on any endocrine gland.Immunohistochemistry: Histochemical localization of immunoreactive substances using labeled antibodies as reagents.Aldosterone: A hormone secreted by the ADRENAL CORTEX that regulates electrolyte and water balance by increasing the renal retention of sodium and the excretion of potassium.Steroidogenic Factor 1: A transcription factor and member of the nuclear receptor family NR5 that is expressed throughout the adrenal and reproductive axes during development. It plays an important role in sexual differentiation, formation of primary steroidogenic tissues, and their functions in post-natal and adult life. It regulates the expression of key steroidogenic enzymes.3-Hydroxysteroid Dehydrogenases: Catalyze the oxidation of 3-hydroxysteroids to 3-ketosteroids.Adrenal Cortex HormonesTumor Markers, Biological: Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including hormones, antigens, amino and nucleic acids, enzymes, polyamines, and specific cell membrane proteins and lipids.Aromatase: An enzyme that catalyzes the desaturation (aromatization) of the ring A of C19 androgens and converts them to C18 estrogens. In this process, the 19-methyl is removed. This enzyme is membrane-bound, located in the endoplasmic reticulum of estrogen-producing cells of ovaries, placenta, testes, adipose, and brain tissues. Aromatase is encoded by the CYP19 gene, and functions in complex with NADPH-FERRIHEMOPROTEIN REDUCTASE in the cytochrome P-450 system.Cell Line, Tumor: A cell line derived from cultured tumor cells.Carcinoma in Situ: A lesion with cytological characteristics associated with invasive carcinoma but the tumor cells are confined to the epithelium of origin, without invasion of the basement membrane.Dehydroepiandrosterone: A major C19 steroid produced by the ADRENAL CORTEX. It is also produced in small quantities in the TESTIS and the OVARY. Dehydroepiandrosterone (DHEA) can be converted to TESTOSTERONE; ANDROSTENEDIONE; ESTRADIOL; and ESTRONE. Most of DHEA is sulfated (DEHYDROEPIANDROSTERONE SULFATE) before secretion.Steroids: A group of polycyclic compounds closely related biochemically to TERPENES. They include cholesterol, numerous hormones, precursors of certain vitamins, bile acids, alcohols (STEROLS), and certain natural drugs and poisons. Steroids have a common nucleus, a fused, reduced 17-carbon atom ring system, cyclopentanoperhydrophenanthrene. Most steroids also have two methyl groups and an aliphatic side-chain attached to the nucleus. (From Hawley's Condensed Chemical Dictionary, 11th ed)Tomography, X-Ray Computed: Tomography using x-ray transmission and a computer algorithm to reconstruct the image.Prognosis: A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.Incidental Findings: Unanticipated information discovered in the course of testing or medical care. Used in discussions of information that may have social or psychological consequences, such as when it is learned that a child's biological father is someone other than the putative father, or that a person tested for one disease or disorder has, or is at risk for, something else.Carcinoma, Papillary: A malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. (Stedman, 25th ed)Tumor Cells, Cultured: Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.Antineoplastic Agents, Hormonal: Antineoplastic agents that are used to treat hormone-sensitive tumors. Hormone-sensitive tumors may be hormone-dependent, hormone-responsive, or both. A hormone-dependent tumor regresses on removal of the hormonal stimulus, by surgery or pharmacological block. Hormone-responsive tumors may regress when pharmacologic amounts of hormones are administered regardless of whether previous signs of hormone sensitivity were observed. The major hormone-responsive cancers include carcinomas of the breast, prostate, and endometrium; lymphomas; and certain leukemias. (From AMA Drug Evaluations Annual 1994, p2079)Neoplasm Staging: Methods which attempt to express in replicable terms the extent of the neoplasm in the patient.RNA, Messenger: RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.Retroperitoneal NeoplasmsInhibins: Glycoproteins that inhibit pituitary FOLLICLE STIMULATING HORMONE secretion. Inhibins are secreted by the Sertoli cells of the testes, the granulosa cells of the ovarian follicles, the placenta, and other tissues. Inhibins and ACTIVINS are modulators of FOLLICLE STIMULATING HORMONE secretions; both groups belong to the TGF-beta superfamily, as the TRANSFORMING GROWTH FACTOR BETA. Inhibins consist of a disulfide-linked heterodimer with a unique alpha linked to either a beta A or a beta B subunit to form inhibin A or inhibin B, respectivelyGene Expression Regulation, Neoplastic: Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in neoplastic tissue.Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Fatal Outcome: Death resulting from the presence of a disease in an individual, as shown by a single case report or a limited number of patients. This should be differentiated from DEATH, the physiological cessation of life and from MORTALITY, an epidemiological or statistical concept.
Thyroid, Parathyroid, Adrenal, Endocrine Surgery, Thyroid, Parathyroid, Adrenals, Endocrine Surgery Site Map
How is Adreno-cortical Carcinoma diagnosed?. *How is Adreno-cortical Carcinoma treated?. *How is an androgen-secreting tumour ... Symptoms and treatment of Medullary Thyroid Carcinoma (MTC) in MEN 2a. *Symptoms and treatment of Medullary Thyroid Carcinoma ( ...http://www.endocrinesurgeon.co.uk/index.php/component/option,com_xmap/Itemid,100508/sitemap,1/
Trial in Locally Advanced and Metastatic Adrenocortical Carcinoma Treatment (FIRM-ACT) - Full Text View - ClinicalTrials.gov
Carcinoma. Adrenocortical Carcinoma. Neoplasms, Glandular and Epithelial. Neoplasms by Histologic Type. Neoplasms. ... Trial in Locally Advanced and Metastatic Adrenocortical Carcinoma Treatment (FIRM-ACT). This study has been completed. ... The Firm-ACT trial is the first ever conducted randomized controlled phase III trial in adrenocortical carcinoma (ACC), a rare ... Further study details as provided by Martin Fassnacht, Collaborative Group for Adrenocortical Carcinoma Treatment:. Primary ...https://clinicaltrials.gov/ct2/show/study/NCT00924144?view=record
Defining the Genetic Basis for the Development of Primary Pigmented Nodular Adrenocortical Disease (PPNAD) and the Carney...
... adrenocortical and thyroid follicular carcinoma, and ovarian cysts). These associations constitute a distinct clinical syndrome ... Primary pigmented nodular adrenocortical disease (PPNAD) is a pituitary-independent, primary adrenal form of hypercortisolism ... Primary pigmented nodular adrenocortical disease (PPNAD) is a pituitary-independent, primary adrenal form of hypercortisolism ... Adrenocortical Hyperfunction. Adrenal Gland Diseases. Endocrine System Diseases. Melanosis. Hyperpigmentation. Pigmentation ...https://clinicaltrials.gov/ct2/show/NCT00001452?recr=Open&cond=%22Cushing+Syndrome%22&rank=13
Adrenal Myelolipoma Imaging: Overview, Radiography, Computed Tomography
Adrenocortical adenoma containing a fat component: CT and MR image evaluation. Abdom Imaging. 1995 Sep-Oct. 20(5):489-90. [ ... Ferrozzi F, Bova D. CT and MR demonstration of fat within an adrenal cortical carcinoma. Abdom Imaging. 1995 May-Jun. 20(3):272 ... Benign adrenocortical masses: diagnosis with chemical shift MR imaging. Radiology. 1992 Nov. 185(2):345-51. [Medline]. ... Adrenocortical neoplasms with myelolipomatous and lipomatous metaplasia: report of 3 cases. Endocr Pract. 2009 Mar. 15(2):128- ...https://emedicine.medscape.com/article/376700-overview
Adrenal metastasis - CT scan: UCLA Endocrine Surgery Encyclopedia
Adrenocortical Carcinoma. Pheochromocytoma. Thyroid Cancer in Children. Thyroid Cancer Staging. Scar Gallery ...http://endocrinesurgery.ucla.edu/patient_education_adm_adrenal_metastasis_ct_scan.html
Repositorio da Producao Cientifica e Intelectual da Unicamp: Mitotane associated with cisplatin, etoposide, and doxorubicin in...
Mitotane associated with cisplatin, etoposide, and doxorubicin in advanced childhood adrenocortical carcinoma - Mitotane ... Purpose: To define a mitotane dose for pediatric patients with adrenocortical cancer (ACC) that maintains therapeutic plasma ...http://repositorio.unicamp.br/jspui/handle/REPOSIP/57127
Adrenocortical carcinoma or choroid plexus tumor (irrespective of family history).] These criteria result in a mutation ... adrenocortical carcinoma, leukemia, lung bronchoalveolar cancer), among others. About 3/4 of patients have a mutation in the ... The images above are from a patient with a history of right adrenal cortical carcinoma (note the clips on the right, pink arrow ... gastric carcinoma, Wilms tumor, lymphoma, and lung, laryngeal, prostate, and pancreatic cancers. The 2009 Chompret (after Agnès ...https://roentgenrayreader.blogspot.com/2011/12/li-fraumeni-syndrome.html
adrenal rest tumor disease finding 2005:2010[pubdate] *count=100 - BioMedLib™ search engine
Shin YM: Hepatic adrenal rest tumor mimicking hepatocellular carcinoma. Korean J Hepatol; 2010 Sep;16(3):338-41. MedlinePlus ... the mass expressed the adrenal 4-binding protein and several enzymes involved in the synthesis of adrenocortical steroids. ... Title] Hepatic adrenal rest tumor mimicking hepatocellular carcinoma.. *[MeSH-major] Adrenal Rest Tumor / radiography. Liver ... in patients with congenital adrenal hyperplasia due to 21-hydroxylase deficiency show functional features of adrenocortical ...http://www.bmlsearch.com/?kwr=adrenal+rest+tumor+disease+finding+2005:2010%5Bpubdate%5D&cxts=100&stmp=b0
Adrenocortical Carcinoma | University Hospitals
Stay connected with University Hospitals with the UH Now app. This mobile application, available on both Android and iPhone, lets you find a doctor, find a location, log in to your UH Personal Health Record, and schedule an appointment. UH Now also lets you explore health topics that are important to you and your family. Take charge of your health by downloading UH Now today, and get health information delivered right to your fingertips - at the time and place you need it most.. Learn More. ...https://www.uhhospitals.org/rainbow/services/pediatric-cancer-and-blood-disorders/conditions-and-treatments/adrenocortical-carcinoma
Adrenocortical Carcinoma Research - National Cancer Institute
Find research articles on adrenocortical carcinoma, which may include news stories, clinical trials, blog posts, and ... A molecular characterization of adrenocortical carcinoma, a rare cancer of the adrenal cortex, analyzed 91 cases for ...https://www.cancer.gov/types/adrenocortical/research
Adrenocortical carcinoma: MedlinePlus Medical Encyclopedia
Adrenocortical carcinoma (ACC) is a cancer of the adrenal glands. The adrenal glands are two triangle-shaped glands. One gland ... Adrenocortical carcinoma (ACC) is a cancer of the adrenal glands. The adrenal glands are two triangle-shaped glands. One gland ... PDQ: adrenocortical carcinoma treatment - health professional version. Updated June 02, 2015. Cancer.gov. www.cancer.gov/types/ ... Allolio B, Fassnacht M. Adrenocortical carcinoma. In: Jameson JL, De Groot LJ, de Kretser DM, et al, eds. Endocrinology: Adult ...https://medlineplus.gov/ency/article/001663.htm
Adrenocortical carcinoma - Wikipedia
Adrenocortical carcinoma is a rare tumor, with incidence of 1-2 per million population annually. Adrenocortical carcinoma has a ... Oncocytic adrenal cortical carcinoma Myxoid adrenal cortical carcinoma Carcinosarcoma Adenosquamous adrenocortical carcinoma ... Adrenocortical carcinoma (ACC, adrenal cortical carcinoma, adrenal cortical cancer, adrenal cortex cancer, etc.) is an ... Adrenocortical adenoma Renal cell carcinoma Adrenal medullary tumors Hepatocellular carcinoma The only curative treatment is ...https://en.wikipedia.org/wiki/Adrenocortical_carcinoma
A Rare Adrenal Incidentaloma That Mimics Adrenocortical Carcinoma
... were adrenocortical carcinoma and 34.7% were metastasis [7, 8]. Patients with adrenocortical carcinoma are usually 40-50 years ... A Rare Adrenal Incidentaloma That Mimics Adrenocortical Carcinoma. Kedar Lavingia, Ramyar Torabi, Samuel W. Kim, Marybeth S. ... The suspicion for adrenocortical carcinoma usually prompts adrenalectomy.. 1. Introduction. Adrenal hemangiomas are rare benign ... Due to the difficulty in distinguishing the lesion from an adrenocortical carcinoma on imaging and due to the small risk of ...https://www.hindawi.com/journals/cris/2018/9607972/
Adrenocortical carcinoma | University of Maryland Medical Center
Adrenocortical carcinoma. Definition. Adrenocortical carcinoma (ACC) is a cancer of the adrenal glands. The adrenal glands are ... PDQ: adrenocortical carcinoma treatment - health professional version. Updated June 02, 2015. Cancer.gov. www.cancer.gov/types/ ... Allolio B, Fassnacht M. Adrenocortical carcinoma. In: Jameson JL, De Groot LJ, de Kretser DM, et al, eds. Endocrinology: Adult ...https://www.umm.edu/Health/Medical/Ency/Articles/Adrenocortical-carcinoma
Search of: 'Adrenocortical carcinoma' - List Results - ClinicalTrials.gov
Natural History and Tissue Acquisition Study of Adrenocortical Carcinoma. *Adrenocortical Carcinoma. Observational. *National ... 65 Studies found for: 'Adrenocortical carcinoma'. Also searched for Adrenocortical cancer and Adrenal carcinoma. See Search ... Single Agent Pembrolizumab in Subjects With Advanced Adrenocortical Carcinoma. *Adrenocortical Carcinoma. *Drug: Pembrolizumab ... A Study of OSI-906 in Patients With Locally Advanced or Metastatic Adrenocortical Carcinoma. *Adrenocortical Carcinoma ...https://clinicaltrials.gov/ct2/results?cond=%22Adrenocortical+carcinoma%22
Adrenocortical Carcinoma | Portsmouth Regional Hospital
Learn more about Adrenocortical Carcinoma at Portsmouth Regional Hospital DefinitionCausesRisk ... Adrenocortical carcinoma is cancer of the adrenal cortex. The adrenal glands are 2 glands located above each kidney. The glands ... Approximately 40% of people with adrenocortical carcinoma do not secrete any hormone. These people do not have any specific ... Adrenocortical carcinoma is discovered as part of a physical examination for abdominal pain. ...https://portsmouthhospital.com/hl/?/179661/Adrenal-cancer&com.dotmarketing.htmlpage.language=1
Adrenocortical Carcinoma-Health Professional Version - National Cancer Institute
Most adrenocortical tumors are functioning. Find evidence-based information on adrenocortical carcinoma including treatment and ... Adrenocortical carcinoma is also called cancer of the adrenal cortex. A tumor of the adrenal cortex may be functioning or ... Adrenocortical Carcinoma Treatment. More information. * Unusual Cancers of Childhood Treatment (PDQ®)-Health Professional ... NCI does not have PDQ evidence-based information about prevention of adrenocortical carcinoma.. More information. * Cancer ...https://www.cancer.gov/types/adrenocortical/hp
Adrenocortical Carcinoma | UVA Health System
Adrenocortical carcinoma is cancer of the adrenal cortex. The adrenal glands are two glands located above each kidney. The ... The cause of adrenocortical carcinoma is unknown.. Risk Factors. A genetic defect may cause adrenocortical cancer in some ... Adrenocortical carcinoma is cancer of the adrenal cortex. The adrenal glands are two glands located above each kidney. The ... Approximately 40 percent of people with adrenocortical carcinoma do not secrete any hormone. These people do not have any ...https://uvahealth.com/services/endocrine-cancer/adrenocortical-carcinoma
Adrenocortical carcinoma CT - wikidoc
Adrenal CT scan may be helpful in the diagnosis of Adrenocortical carcinoma (ACC) and in differentiating it from other diseases ... "Adrenocortical carcinoma: the range of appearances on CT and MRI.". AJR Am J Roentgenol. 196 (6): W706-14. PMID 21606258. doi: ... "Adrenocortical carcinoma: the range of appearances on CT and MRI.". AJR Am J Roentgenol. 196 (6): W706-14. PMID 21606258. doi: ... "Primary adrenocortical carcinoma: CT evaluation with clinical correlation.". AJR Am J Roentgenol. 148 (3): 531-5. PMID 3492881 ...http://wikidoc.org/index.php/Adrenocortical_carcinoma_CT
Changes in the Evaluation and Management of Adrenocortical Carcinoma | SpringerLink
Resection of adrenocortical carcinoma is less complete and local recurrence occurs sooner and more often after laparoscopic ... For decades, little progress was made in improving outcomes for patients with adrenocortical carcinoma (ACC). During the past ... Evaluation, staging, and surgical management for adrenocortical carcinoma: an update from the SSO Endocrine and Head and Neck ... Linsitinib (OSI-906) versus placebo for patients with locally advanced or metastatic adrenocortical carcinoma: a double-blind, ...https://link.springer.com/article/10.1245%2Fs10434-018-6754-5
Cook Children's Health Library - Adrenocortical Carcinoma - Conditions - 179661
Adrenocortical Carcinoma. (Cancer of the Adrenal Cortex; Adrenal Cortical Carcinoma; Adrenal Cancer). by Amanda Barrett, MA ... Adrenocortical carcinoma is cancer of the adrenal cortex. The adrenal glands are 2 glands located above each kidney. The glands ... General information about adrenocortical carcinoma. National Cancer Institute website. Available at: ...(Click grey area to ... Approximately 40% of people with adrenocortical carcinoma do not secrete any hormone. These people do not have any specific ...http://healthlibrary.epnet.com/GetContent.aspx?token=83ee77b6-5d7c-451c-b269-7f0bab6eb1f5&chunkiid=179661
Adrenal Gland Cancer (Adrenocortical Carcinoma) | Cleveland Clinic: Health Library
... adrenocortical carcinoma) from the Cleveland Clinic, including symptoms, treatment options & more. ... Adrenocortical carcinoma may be cured if treated at an early stage.. Stages of Adrenocortical Carcinoma. *After adrenocortical ... Stage I Adrenocortical Carcinoma. Treatment of stage I adrenocortical carcinoma may include the following:. *Surgery ( ... Stage II Adrenocortical Carcinoma. Treatment of stage II adrenocortical carcinoma may include the following:. *Surgery ( ...https://my.clevelandclinic.org/health/articles/6152-adrenocortical-carcinoma
Adrenocortical Carcinoma - Pipeline Review, H1 2017
H1 2017 Adrenocortical Carcinoma - Pipeline Review, H1 2017 Summary Global Markets Direct's latest Pharmaceutical and ... Healthcare disease pipeline guide Adrenocortical Carcinoma - Market research report and industry analysis - 10909461 ... Adrenocortical Carcinoma (Adrenal Cortex Cancer) - Pipeline by ArQule Inc, H1 2017. Adrenocortical Carcinoma (Adrenal Cortex ... Adrenocortical Carcinoma (Adrenal Cortex Cancer) - Pipeline by Exelixis Inc, H1 2017. Adrenocortical Carcinoma (Adrenal Cortex ...https://www.marketresearch.com/Global-Markets-Direct-v3480/Adrenocortical-Carcinoma-Pipeline-Review-H1-10909461/
Adrenocortical Carcinoma (Adrenal Cortex Cancer) - Pipeline Insights, 2017
Adrenocortical Carcinoma (Adrenal Cortex Cancer) Phase I and IND Filed Products. Comparative Analysis. Adrenocortical Carcinoma ... Adrenocortical Carcinoma (Adrenal Cortex Cancer) Filed and Phase III Products. Comparative Analysis. Adrenocortical Carcinoma ( ... Adrenocortical Carcinoma (Adrenal Cortex Cancer) Assessment by Stage and Route of Administration. Adrenocortical Carcinoma ( ... Adrenocortical Carcinoma (Adrenal Cortex Cancer) Assessment by Stage and Molecule Type. Adrenocortical Carcinoma (Adrenal ...https://www.researchandmarkets.com/reports/4036542/adrenocortical-carcinoma-adrenal-cortex-cancer
Surgery and Heated Chemotherapy for Adrenocortical Carcinoma - Full Text View - ClinicalTrials.gov
Carcinoma. Adrenocortical Carcinoma. Neoplasms, Glandular and Epithelial. Neoplasms by Histologic Type. Neoplasms. ... Surgery and Heated Chemotherapy for Adrenocortical Carcinoma. The safety and scientific validity of this study is the ... Adrenocortical carcinoma (ACC) is a rare tumor of the adrenal gland. Few people who develop this disease live more than 5 years ... Adrenocortical Carcinoma Peritoneal Carcinomatosis Drug: Cisplatin Procedure: Cytoreductive surgery Drug: sodium thiosulfate ...https://clinicaltrials.gov/ct2/show/NCT01833832?recr=Open&cond=%22Adrenal+Gland+Neoplasms%22&rank=19
... is a rare tumor, with incidence of 1-2 per million population annually. Adrenocortical carcinoma has a ... Oncocytic adrenal cortical carcinoma Myxoid adrenal cortical carcinoma Carcinosarcoma Adenosquamous adrenocortical carcinoma ... Adrenocortical carcinoma (ACC, adrenal cortical carcinoma, adrenal cortical cancer, adrenal cortex cancer, etc.) is an ... Adrenocortical adenoma Renal cell carcinoma Adrenal medullary tumors Hepatocellular carcinoma The only curative treatment is ...
Allolio B, Fassnacht M (2006). "Adrenocortical Carcinoma: Clincal Update". J Clin Endocrinol Metab. 91 (6): 2027-2037. doi: ... excluding Cushing's Another cause for Cushing's syndrome is adrenocortical carcinoma (ACC). This is a rare form of cancer with ...
... was introduced in 1960 for the treatment of adrenocortical carcinoma. Mitotane is the INN, USAN, BAN, and JAN of ... 1888-. ISBN 1-4557-1126-8. Hahner S, Fassnacht M (April 2005). "Mitotane for adrenocortical carcinoma treatment". Current ... Mitotane has been produced by Bristol Myers Squibb SpA but it is marketed as an orphan drug for adrenocortical carcinoma due to ... "Adjuvant mitotane treatment for adrenocortical carcinoma". N Engl J Med. 356 (23): 2372-2380. doi:10.1056/NEJMoa063360. PMID ...
It was initially isolated in 1980 from a 48-year-old female patient diagnosed with adrenocortical carcinoma. The initial ... Wang T, Rainey WE (2012). "Human Adrenocortical Carcinoma Cell Lines". Mol. Cell. Endocrinol. 351 (1): 58-65. doi:10.1016/j.mce ... "Establishment and characterization of a human adrenocortical carcinoma cell line that expresses multiple pathways of steroid ... Rainey WE, Saner K, Schimmer BP (2004). "Adrenocortical cell lines". Mol. Cell. Endocrinol. 228 (1-2): 23-38. doi:10.1016/j.mce ...
Chen, David Y. T.; Sosa, RE; Scherr, DS (2004). "Treatment of adrenocortical carcinoma: Contemporary outcomes". Current Urology ... Barocas, DA; Mathew, S; Delpizzo, JJ; Vaughan Ed, ED; Sosa, RE; Fine, RG; Akhtar, M; Scherr, DS (2007). "Renal cell carcinoma ... Barocas, DA; Rabbani, F; Scherr, DS; Vaughan Ed, ED (2006). "A population-based study of renal cell carcinoma and prostate ... Raman, JD; Scherr, DS (2007). "Management of patients with upper urinary tract transitional cell carcinoma". Nature Clinical ...
More recently JAG1 expression has been found to be altered in breast cancer and adrenocortical carcinoma patients. Mouse models ... Simon DP, Giordano TJ, Hammer GD (2012). "Upregulated JAG1 enhances cell proliferation in adrenocortical carcinoma". Clin. ... with both poor overall breast cancer survival rates and an enhancement of tumor proliferation in adrenocortical carcinoma ... "Gene alterations identified by expression profiling in tumor-associated endothelial cells from invasive ovarian carcinoma". ...
Mir-497 microRNA precursor family
"The role of microRNA deregulation in the pathogenesis of adrenocortical carcinoma". Endocrine Related Cancer. 18 (6): 643-655. ... "Alteration of microRNA profiles in squamous cell carcinoma of the head and neck cell lines by human papillomavirus". Head & ... "Potentially important microRNA cluster on chromosome 17p13.1 in primary peritoneal carcinoma". Modern Pathology. 22 (2): 197- ...
Mir-503 microRNA precursor family
"The role of microRNA deregulation in the pathogenesis of adrenocortical carcinoma". Endocrine Related Cancer. 18 (6): 643-655. ... "Effect of YB-1 on the regulation of micro RNA expression in drug-sensitive and drug-resistant gastric carcinoma cells". ... "Differential expression of microRNAs in human parathyroid carcinomas compared with normal parathyroid tissue". Endocrine ... "Integrative molecular bioinformatics study of human adrenocortical tumors: MicroRNA, tissue-specific target prediction, and ...
Deaths in December 2011
... adrenocortical carcinoma. Carmen Rupe, 75, New Zealand transsexual entertainer, kidney failure. Mario Tovar González, 78, ...
A phase III clinical trial found that linsitinib did not increase survival in patients with adrenocortical carcinoma. As of ... Linsitinib was granted orphan drug designation for adrenocortical carcinoma in March 2012. Phase II clinical trials were ... versus placebo for patients with locally advanced or metastatic adrenocortical carcinoma: a double-blind, randomised, phase 3 ... initiated for multiple myeloma, ovarian cancer, hepatocellular carcinoma, and NSCLC, but subsatisfactory results caused ...
David Velázquez Fernández
2010) The role of microRNA deregulation in the pathogenesis of adrenocortical carcinoma. Endocr Relat Cancer. (2011) Primary ... 2004) Expression Profiling of Adrenocortical Tumors Suggests a Molecular Signature of Malignancy. (2005) Differential RNA ... 2008) Transcriptional profiling enables molecular classification of adrenocortical tumours. European Journal of Endocrinology ... Accuracy of centinel node in papillary thyroid carcinoma (2001) Quality of life in bariatric surgery (2002) Utilidad de la ...
80% of children with adrenocortical carcinoma and 2%-10% of childhood brain tumors have p53 mutations. 2%-3% of osteosarcomas, ... lymphoma and adrenocortical carcinoma. ~90% of females with LFS develop breast cancer by age 60 years; the majority of these ... adrenocortical carcinoma, leukemia or lung bronchoalveolar cancer - before age 46 years; and at least one of the following: at ... tumour spectrum and the first of which occurred before age 46 years a proband who is diagnosed with adrenocortical carcinoma or ...
The Cancer Genome Atlas
... esophageal carcinoma, ovarian serous cystadenocarcinoma, lung squamous cell carcinoma, adrenocortical carcinoma, Diffuse Large ... kidney papillary carcinoma, clear cell kidney carcinoma, breast ductal carcinoma, renal cell carcinoma, cervical cancer ( ... hepatocellular carcinoma, Head and neck (oral) squamous cell carcinoma, thyroid carcinoma, bladder urothelial carcinoma - ... squamous cell carcinoma of the head and neck, colon cancer, rectal cancer, bladder cancer, kidney clear cell carcinoma, ovarian ...
MBZ significantly inhibited cancer cell growth, migration, and metastatic formation of adrenocortical carcinoma, both in vitro ... "Mebendazole inhibits growth of human adrenocortical carcinoma cell lines implanted in nude mice". Cancer Chemother. Pharmacol. ...
"Regression of hypertrophic osteopathy in a cat after surgical excision of an adrenocortical carcinoma". J Am Anim Hosp Assoc. ...
Mir-210 has been suggested as a useful biomarker to distinguish adrenocortical carcinoma from adrenocortical adenoma. mir-210 ... "Analysis of circulating microRNAs in adrenocortical tumors". Laboratory Investigation; A Journal of Technical Methods and ...
... adrenocortical carcinoma and some adrenal pheochromocytomas. Most adrenal pheochromocytomas and all adrenocortical adenomas are ... Adrenocortical carcinoma (ACC) is a rare, highly aggressive cancer of adrenal cortical cells, which may occur in children or ... Due to their location deep in the retroperitoneum, most adrenocortical carcinomas are not diagnosed until they have grown quite ... Functional adrenocortical adenomas are surgically curable. Most of the adrenocortical adenomas are less than 2 cm in greatest ...
... for example adrenocortical carcinoma and non-small cell lung cancer (NSCLC). This drug was being developed by Pfizer, but they ... and pharmacokinetics of the anti-IGF-1R monoclonal antibody figitumumab in patients with refractory adrenocortical carcinoma". ...
Hormonal therapy (oncology)
... such as Cushing's syndrome and hyperaldosteronism in adrenocortical carcinoma. Analogs of gonadotropin-releasing hormone (GnRH ... including renal cell carcinoma and melanoma. List of hormonal alkylating antineoplastic agents DeVita, Vincent T.; Hellman, ...
List of incurable diseases
Adrenocortical carcinoma - A form of cancer that originates in the cortex of the adrenal gland and has no definitive cure.[ ...
Adrenal gland tumors, adrenocortical adenomas, and adrenocortical carcinoma, as well as adrenal hyperplasia due to pituitary ...
... and adenomatous adrenal tissue but not in aggressive adrenocortical carcinomas". Surgery. 136 (6): 1122-8. doi:10.1016/j.surg. ... "Squamous cell carcinoma related oncogene/DCUN1D1 is highly conserved and activated by amplification in squamous cell carcinomas ... "Squamous cell carcinoma related oncogene/DCUN1D1 is highly conserved and activated by amplification in squamous cell carcinomas ... novel oncogenes squamous cell carcinoma-related oncogene and phosphatidylinositol 3-kinase p110alpha in squamous cell carcinoma ...
... tumors Non-functioning endocrine pancreatic tumors Insulinoma Gastrinoma Glucagonoma VIPoma Adrenals Adrenocortical carcinoma ... to as Rectal carcinoid Pulmonary Typical bronchial carcinoid Atypical bronchial carcinoid Large cell neuroendocrine carcinoma ...
... adrenocortical carcinoma, and lung, ovarian, and breast cancer. Alignment of this gene to genomic sequence data suggests that ...
(1/185) YM116, 2-(1H-imidazol-4-ylmethyl)-9H-carbazole, decreases adrenal androgen synthesis by inhibiting C17-20 lyase activity in NCI-H295 human adrenocortical carcinoma cells.
The concentrations of androstenedione and dehydroepiandrosterone, products of C17-20 lyase, in the medium after a 6-hr incubation of NCI-H295 cells were decreased by YM116 (2-(1H-imidazol-4-ylmethyl)-9H-carbazole) (IC50: 3.6 and 2.1 nM) and ketoconazole (IC50: 54.9 and 54.2 nM). 17Alpha-hydroxyprogesterone, a product of 17alpha-hydroxylase, was increased by YM116 (1-30 nM) and by ketoconazole (10-300 nM) and then was decreased at higher concentrations of both agents (IC50: 180 nM for YM116, 906 nM for ketoconazole), indicating that YM116 and ketoconazole were 50- and 16.5-fold more specific inhibitors of C17-20 lyase, respectively, than 17alpha-hydroxylase. Compatible with these findings, progesterone, a substrate of 17alpha-hydroxylase, was increased by these agents. Cortisol production was inhibited by YM116 and ketoconazole (IC50: 50.4 and 80.9 nM, respectively). YM116 was a 14-fold more potent inhibitor of androstenedione production than cortisol production, whereas ketoconazole was a nonselective inhibitor of the production of both steroids. YM116 and ketoconazole inhibited the C17-20 lyase activity in human testicular microsomes (IC50: 4.2 and 17 nM, respectively). These results demonstrate that YM116 reduces the synthesis of adrenal androgens by preferentially inhibiting C17-20 lyase activity. (+info)
(2/185) Comparison of expression and regulation of the high-density lipoprotein receptor SR-BI and the low-density lipoprotein receptor in human adrenocortical carcinoma NCI-H295 cells.
In rodents, cholesterol for adrenal steroidogenesis is derived mainly from high-density lipoproteins (HDL) via the HDL receptor, scavenger receptor-BI (SR-BI). In humans cholesterol for steroidogenesis is considered to be derived from the low-density lipoprotein (LDL) receptor pathway, and the contribution of SR-BI to that is unknown. In the present study SR-BI expression and regulation by steroidogenic stimuli was analysed in human adrenocortical cells and compared with LDL receptor expression. In addition, the functional contribution of both receptors for cholesteryl ester delivery to human adrenocortical cells was compared. Northern blot and reverse transcription-PCR amplification and sequence analysis demonstrated the presence of SR-BI mRNA in foetal and adult human adrenal cortex. Furthermore, SR-BI mRNA was expressed to similar levels in human primary adrenocortical and adrenocortical carcinoma NCI-H295 cells, indicating its presence in the steroid-producing cells. Treatment of NCI-H295 cells with 8Br-cAMP, a stimulator of glucocorticoid synthesis via the protein kinase A second messenger signal transduction pathway, resulted in an increase of both SR-BI and LDL receptor mRNA levels in a time- and dose-dependent manner. The induction of SR-BI and LDL receptor by cAMP was independent of ongoing protein synthesis and occurred at the transcriptional level. Ligand blot experiments indicated that a protein of similar size to SR-BI is the major HDL-binding protein in NCI-H295 cells. Western blot analysis demonstrated that cAMP treatment increased the levels of LDL receptor and, to a lesser extent, SR-BI protein in NCI-H295 cells. Binding and uptake of cholesterol was quantitatively smaller from HDL than from LDL, both in basal as well as in cAMP-stimulated cells. Scatchard analysis under basal conditions indicated that NCI-H295 cells express twice as many specific binding sites for LDL than for HDL. Dissociation constant values (Kd; in nm) were approximately five times higher for HDL than for LDL, indicating a lower affinity of HDL compared with LDL. The combined effects of these two parameters and the low cholesteryl ester content of HDL subfraction 3 (HDL3) contributes to a lower cholesteryl ester uptake from HDL than from LDL by the NCI-H295 cells. In conclusion, both the SR-BI and LDL receptor genes are expressed in the human adrenal cortex and coordinately regulated by activators of glucocorticoid synthesis. In contrast to rodents, in human adrenocortical cells the HDL pathway of cholesterol delivery appears to be of lesser importance than the LDL pathway. Nevertheless, the SR-BI pathway may become of major importance in conditions of functional defects in the LDL receptor pathway. (+info)
(3/185) The expression of inhibin/activin subunits in the human adrenal cortex and its tumours.
Inhibins and activins are dimeric proteins of the transforming growth factor-beta superfamily which have been shown to be expressed in the adrenal cortex. Recent studies have suggested a role for these peptides in the pathogenesis and/or function of adrenal tumours. To investigate further their physiological and pathological roles, we have documented immunoreactivity for inhibin alpha, betaA and betaB subunits in normal adult and fetal human adrenals, in hyperplastic adrenals and in adrenal tumours. In the normal and hyperplastic adult gland, diffuse immunopositivity was demonstrated for beta subunits, suggesting that activins (beta beta dimers) can be expressed in all zones. Inhibin alpha was limited to the zona reticularis and the innermost zona fasciculata in the normal gland, extending centripetally into the zona fasciculata in hyperplasia, supporting a role for ACTH in the regulation of expression, and suggesting that expression of inhibins (alpha beta dimers) is restricted. Immunopositivity for all three subunits was seen in both fetal and definitive zones of the fetal cortex, indicating that both inhibins and activins could be expressed in both. Immunopositivity for all three subunits was seen in most adrenocortical tumours. Loss of immunopositivity for inhibin alpha in a subgroup of carcinomas might indicate a role in tumour progression. The greater intensity of staining for inhibin alpha in tumours associated with Cushing's syndrome again suggests a link with cortisol production. (+info)
(4/185) Autocrine role of IGF-II in proliferation of human adrenocortical carcinoma NCI H295R cell line.
In adrenocortical tumors, the malignant phenotype is associated with rearrangements (paternal isodisomy) at the 11p15 locus and IGF-II gene overexpression, strongly suggesting that the IGF system is a major determinant of adrenocortical tumor progression. The aim of this study was to validate an in vitro model for investigating the involvement of the IGF system in adrenocortical tumorigenesis. We analyzed the production of IGF mRNA and proteins, IGF-binding proteins (IGFBPs) and IGF receptors by the NCI H295R cell line, which is derived from a human adult adrenocortical carcinoma. H295R cells were shown to proliferate for a long period (26 days) in the absence of serum or any added growth factor. Northern blot analyses showed high IGF-II mRNA contents in H295R cells. The cells secreted large amounts of IGF-II protein (14 ng/10(6) cells per 48 h) although no IGF-I protein was detected. Western ligand blot analyses of conditioned media detected the presence of large amounts of a 34 kDa protein, which was identified as IGFBP-2 by immunoblotting. The presence of high-affinity binding sites for IGF-I and IGF-II on H295R cells was shown by binding experiments using radiolabeled IGFs and confirmed by reverse transcription PCR analyses showing type 1 and type 2 IGF receptors. Proliferation of H295R cells was inhibited by anti-IGF-II antibody (45%) and by anti-type 1 IGF receptor antibody (53%) indicating that IGF-II is an autocrine growth factor for these cells and that its effects are, at least in part, mediated by the type 1 IGF receptor. These findings confirm the involvement of the IGF system in adrenocortical tumors and suggest that the H295R cell line is a suitable in vitro model for studying the molecular mechanisms of adrenocortical tumor proliferation. (+info)
(5/185) Lack of response to octreotide in Cushing's syndrome due to metastatic adrenocortical carcinoma.
Functional metastatic adrenocortical carcinoma is an uncommon cause of Cushing's syndrome, which rarely responds to conventional treatment. A patient presenting with Cushing's syndrome secondary to adrenocortical carcinoma underwent surgical resection. Postoperatively, she developed metastatic disease resistant to conventional chemotherapy. Octreotide, a somatostatin analogue which is effective in the treatment of several types of neuroendocrine tumour, was tried to ameliorate her secretory symptoms, but without any therapeutic effect. (+info)
(6/185) Analysis of genomic alterations in sporadic adrenocortical lesions. Gain of chromosome 17 is an early event in adrenocortical tumorigenesis.
Genetic changes underlying the tumorigenesis of sporadic adrenocortical tumors are poorly characterized. To search for characteristic genomic imbalances involved in adrenocortical tumors, we examined 41 adrenocortical lesions (12 carcinomas, 23 adenomas, and 6 hyperplasias) by comparative genomic hybridization. Our results show that genetic alterations are more frequent in malignant than in benign lesions and that they rarely occur in hyperplastic lesions. The most frequent DNA copy number changes in adrenocortical carcinomas included losses of 1p21-31, 2q, 3p, 3q, 6q, 9p, and 11q14-qter, as well as gains and amplifications of 5q12, 9q32-qter, 12q, and 20q. The genomic aberrations prevalently occurring in adrenocortical adenomas were gains of 17q, 17p, and 9q32-qter. Gains found in 2 of 6 adrenocortical hyperplastic lesions involved chromosome 17 or 17q only. These data indicate that oncogenes determining the early tumorigenesis of adrenocortical tumors may exist on chromosome 17 and that the number of genomic alterations is closely associated with tumor behavior in adrenocortical tumors. (+info)
(7/185) Changes in neoplastic cell features and sensitivity to mitotane during mitotane-induced remission in a patient with recurrent, metastatic adrenocortical carcinoma.
A 58-year-old man had adrenocortical carcinoma in the right adrenal gland. The tumour secreted excessive cortisol and dehydroepiandrosterone-sulphate (DHEA-S), and had invaded the right hepatic lobe and vena cava. Eleven months after surgical tumour resection, the serum DHEA-S levels again increased. Local tumour recurrence and a metastasis was found in the lung. Eleven months after surgery chemotherapy with mitotane (o,p'-DDD) was initiated. Twelve weeks of mitotane reduced serum DHEA-S levels and caused these tumours to disappear. The patient was then treated with low-dose mitotane (1.5-2.0 g/day) for 2 years. Serum levels of mitotane remained at less than 10 microg/ml. Although such low serum levels of mitotane and delayed initiation of mitotane after surgery have been proposed to weaken the antineoplastic effect of mitotane, the patient had a remission for 2 years. However, there was then local re-recurrence with an increase in serum DHEA-S and death 4 months later. The histological features of neoplastic cells were quite different comparing tumour resected at surgery and tumour at autopsy. The latter had more frequent mitotic nuclei. This tumour was initially sensitive to mitotane, but later became insensitive. (+info)
(8/185) Expression of inhibin alpha in adrenocortical tumours reflects the hormonal status of the neoplasm.
Inhibins are gonadal glycoprotein hormones whose main endocrine function is to inhibit pituitary FSH secretion. In addition to testes and ovaries, other steroid-producing organs are sites of inhibin alpha subunit expression. To study the role of inhibins in human adrenal gland, we screened a panel of 150 adrenals (10 normal adrenals, 25 adrenocortical hyperplasias, 65 adrenocortical adenomas, 30 adrenocortical carcinomas and 20 phaeochromocytomas) for inhibin alpha expression. mRNA levels of inhibin alpha subunit were studied in 57 samples and all tissues were stained immunohistochemically with an inhibin alpha subunit-specific antibody. Inhibin alpha mRNA was detected in all adrenocortical tissues. Virilizing adenomas possessed a 10-fold higher median inhibin alpha mRNA expression than did normal adrenals. Bilaterally and nodularly hyperplastic adrenals and other than virilizing adrenocortical tumours had their median inhibin alpha mRNA levels close to those of normal adrenals. Immunohistochemically, inhibin alpha subunit was detectable in all normal and hyperplastic adrenals, as well as in 73% of the adrenocortical tumours. However, the percentage of inhibin alpha-positive cells varied greatly in different tumour types. The median percentage of positive cells was 10 in non-functional and Conn's adenomas, 30 in Cushing's adenomas and 75 in virilizing adenomas. In malignant adrenocortical tumours the median percentage of inhibin alpha-immunopositive cells was 20 in non-functional carcinomas, 30 in Conn's carcinomas, 65 in Cushing's carcinomas and 75 in virilizing carcinomas. All phaeochromocytomas were negative for inhibin alpha subunit both at the mRNA level and immunohistochemically. Our data show that inhibin alpha subunit is highly expressed in both normal and neoplastic androgen-producing adrenocortical cells, with less expression in cortisol-producing and hardly any in aldosterone-producing cells. This suggests a specific role for inhibins in the regulation of adrenal androgen production. We did not find any significant difference in inhibin alpha expression between benign and malignant adrenocortical tumours. Thus inhibin alpha gene does not seem to have a tumour suppressor role in human adrenal cortex. (+info)
- PPNAD can be associated with a variety of other manifestations, such as myxomas of the skin, heart, breast and other sites, psammomatous melanotic swannomas involving the peripheral nervous system (PNS), lentigines and blue nevi of the skin and mucosae, growth hormone (GH)-producing adenomas of the pituitary, testicular Sertoli cell tumors, and possibly other neoplasms (adrenocortical and thyroid follicular carcinoma, and ovarian cysts). (clinicaltrials.gov)
- Montone et al presented pathologic and radiographic features of 3 patients with adrenocortical neoplasms. (medscape.com)
- Pathologically, 2 of the lesions were classified as adrenocortical neoplasms of uncertain malignant potential, and 1 lesion was classified as an adrenocortical adenoma. (medscape.com)
- Clinical and biological features in the prognosis of adrenocortical cancer: poor outcome of cortisol-secreting tumors in a series of 202 consecutive patients. (portsmouthhospital.com)
- Most adrenocortical tumors are functioning. (clevelandclinic.org)
- Adrenocortical carcinoma can be classified into functioning and nonfunctioning tumors by clinical and biochemical assessment. (cigna.com)
- Shares of Tekmira Pharmaceuticals Corporation (Tekmira) rallied after the Company provided a clinical study update of TKM-PLK1 Phase I/II in patients with advanced Gastrointestinal Neuroendocrine Tumors (GI-NET) and Adrenocortical Carcinoma (ACC). (thefreedictionary.com)
- Adrenocortical carcinoma is remarkable for the many hormonal syndromes which can occur in patients with steroid hormone-producing ("functional") tumors, including Cushing's syndrome, Conn syndrome, virilization, and feminization. (wikipedia.org)
- Expression of the h19 gene is markedly reduced in both nonfunctioning and functioning adrenal cortical carcinomas, especially in tumors producing cortisol and aldosterone. (wikipedia.org)
- Bilateral adrenocortical tumors are less common than unilateral. (wikipedia.org)
- Adrenal cancer is the presence of malignant adrenal tumors, and includes neuroblastoma, adrenocortical carcinoma and some adrenal pheochromocytomas. (wikipedia.org)
- Most adrenal pheochromocytomas and all adrenocortical adenomas are benign tumors, which do not metastasize or invade nearby tissues, but may cause significant health problems by unbalancing hormones. (wikipedia.org)
- Adrenocortical adenomas are benign tumors of the adrenal cortex which are extremely common (present in 1-10% of persons at autopsy). (wikipedia.org)
- MBZ significantly inhibited cancer cell growth, migration, and metastatic formation of adrenocortical carcinoma, both in vitro and in vivo. (wikipedia.org)
- High levels of interleukin-13 receptor alpha 2 (IL13Rα2) are observed in ACC and in malignant pheochromocytoma, pancreatic ductal adenocarcinoma, and hepatocellular carcinoma. (knowcancer.com)
- 2. Pathological confirmation of adrenocortical carcinoma (ACC) or malignant pheochromocytoma, pancreatic adenocarcinoma, and hepatocellular carcinoma. (knowcancer.com)
- 3. Subjects with hepatocellular carcinoma must have a Child-Pugh classification of "A". 4. (knowcancer.com)
- Surgical resection, if possible, for pancreatic adenocarcinoma and hepatocellular carcinoma. (knowcancer.com)
- Failed at least one FDA approved systemic chemotherapy regimen for pancreatic adenocarcinoma (eg, fluorouracil, erlotinib, gemcitabine, and/or mitomycin) and hepatocellular carcinoma (eg, sorafenib). (knowcancer.com)
- Tumor thrombus can be caused by primary tumor arising from the vessel wall as in leiomyosarcoma or by extension from an adjacent organ--most commonly in renal cell carcinoma, hepatocellular carcinoma, adrenocortical carcinoma , or retroperitoneal metastasis. (thefreedictionary.com)
- Phase II clinical trials were initiated for multiple myeloma, ovarian cancer, hepatocellular carcinoma, and NSCLC, but subsatisfactory results caused research for these indications to be discontinued. (wikipedia.org)
- A molecular characterization of adrenocortical carcinoma, a rare cancer of the adrenal cortex, analyzed 91 cases for alterations in the tumor genomes and identified several novel genetic mutations as likely mechanisms driving the disease as well as whole genome doubling as a probable driver of the disease. (cancer.gov)
- Adrenocortical carcinoma (ACC) is a cancer of the adrenal glands . (medlineplus.gov)
- Cancer.gov. www.cancer.gov/types/adrenocortical/hp/adrenocortical-treatment-pdq#section/all . (medlineplus.gov)
- Also searched for Adrenocortical cancer and Adrenal carcinoma . (clinicaltrials.gov)
- Adrenocortical carcinoma is cancer of the adrenal cortex. (portsmouthhospital.com)
- A genetic defect may cause adrenocortical cancer in some children, but the majority of cases are nonhereditary. (portsmouthhospital.com)
- Adrenocortical carcinoma is a rare disease in which malignant (cancer) cells form in the outer layer of the adrenal gland. (clevelandclinic.org)
- It also reviews key players involved in the therapeutic development for Adrenocortical Carcinoma (Adrenal Cortex Cancer). (thefreedictionary.com)
- Adrenocortical carcinoma (ACC, adrenal cortical carcinoma, adrenal cortical cancer, adrenal cortex cancer, etc.) is an aggressive cancer originating in the cortex (steroid hormone-producing tissue) of the adrenal gland. (wikipedia.org)
- The main etiologic factor of adrenocortical cancer is unknown. (wikipedia.org)
- More recently JAG1 expression has been found to be altered in breast cancer and adrenocortical carcinoma patients. (wikipedia.org)
- Adrenocortical carcinoma (ACC) is a rare, highly aggressive cancer of adrenal cortical cells, which may occur in children or adults. (wikipedia.org)
- Figitumumab (previously CP-751871) is a monoclonal antibody targeting the insulin-like growth factor-1 receptor that was investigated for the treatment of various types of cancer, for example adrenocortical carcinoma and non-small cell lung cancer (NSCLC). (wikipedia.org)
- these often appear normal in Cushing's In the alcoholic patient with pseudo-Cushing's, admission to hospital (and avoidance of alcohol) will result in normal midnight cortisol levels within five days, excluding Cushing's Another cause for Cushing's syndrome is adrenocortical carcinoma (ACC). (wikipedia.org)
- Mitotane, sold under the brand name Lysodren, is a steroidogenesis inhibitor and cytostatic antineoplastic medication which is used in the treatment of adrenocortical carcinoma and Cushing's syndrome. (wikipedia.org)
- Second, a minority (about 15%) of adrenocortical adenomas are "functional", meaning that they produce glucocorticoids, mineralcorticoids, and/or sex steroids, resulting in endocrine disorders such as Cushing's syndrome, Conn's syndrome (hyperaldosteronism), virilization of females, or feminization of males. (wikipedia.org)
- Adrenocortical carcinoma and pheochromocytoma can occur in both adults and children. (clevelandclinic.org)
- Rarely, pheochromocytoma-like hypersecretion of catecholamines has been reported in adrenocortical cancers. (wikipedia.org)
- Adrenocortical carcinomas (ACCs) are rare malignancies characterized by a poor prognosis. (thefreedictionary.com)
- Global Markets Direct's latest Pharmaceutical and Healthcare disease pipeline guide Adrenocortical Carcinoma - Pipeline Review, H1 2017, provides an overview of the Adrenocortical Carcinoma (Oncology) pipeline landscape. (marketresearch.com)
- Adrenal CT scan may be helpful in the diagnosis of Adrenocortical carcinoma (ACC) and in differentiating it from other diseases, such as adrenocortical adenoma . (wikidoc.org)
- Radiological studies of the abdomen, such as CT scans and magnetic resonance imaging are useful for identifying the site of the tumor, differentiating it from other diseases, such as adrenocortical adenoma, and determining the extent of invasion of the tumor into surrounding organs and tissues. (wikipedia.org)
- Mir-210 has been suggested as a useful biomarker to distinguish adrenocortical carcinoma from adrenocortical adenoma. (wikipedia.org)
- Mitotane has been produced by Bristol Myers Squibb SpA but it is marketed as an orphan drug for adrenocortical carcinoma due to the small number of patients in need of it. (wikipedia.org)
- Linsitinib was granted orphan drug designation for adrenocortical carcinoma in March 2012. (wikipedia.org)
- A phase III clinical trial found that linsitinib did not increase survival in patients with adrenocortical carcinoma. (wikipedia.org)
- Allolio B, Fassnacht M. Adrencortical carcinoma: clinical update. (portsmouthhospital.com)
- Primary adrenocortical carcinoma: CT evaluation with clinical correlation. (wikidoc.org)
- Adrenocortical Carcinoma: Basic Science and Clinical Concepts. (cigna.com)
- The suspicion for adrenocortical carcinoma usually prompts adrenalectomy. (hindawi.com)
- Open adrenalectomy for medium sized adrenocortical tumour: how I do it? (thefreedictionary.com)
- Adrenal hemangiomas are radiographically difficult to distinguish from adrenocortical carcinoma and usually undergo surgical resection for this reason. (hindawi.com)
- The majority of bilateral tumours can be distinguished according to size and aspect of the nodules: primary pigmented nodular adrenocortical disease which can be sporadic or part of Carney complex and primary bilateral macro nodular adrenal hyperplasia. (wikipedia.org)
- They should not be confused with adrenocortical "nodules", which are not true neoplasms. (wikipedia.org)
- Adrenocortical carcinoma is a rare tumor, with incidence of 1-2 per million population annually. (wikipedia.org)
- Adrenocortical adenomas are uncommon in patients younger than 30 years old, and have equal incidence in both sexes. (wikipedia.org)
- Schematic representation of the fetoplacental interactions in our co-culture model of H295R human (fetal-like) adrenocortical carcinoma and BeWo human (trophoblast-like) choriocarcinoma cells. (thefreedictionary.com)
- In a recent study at the INRS-Institut Armand-Frappier (Laval, Quebec, Canada) the E-Plate Insert had been used to test the behaviour of BeWo human placental choriocarcinoma cells in co-culture with H295R human adrenocortical carcinoma cells. (thefreedictionary.com)
- The human adrenocortical carcinoma cell line H295R expresses all key enzymes involved in the synthesis of adrenocorticol steroid hormones from cholesterol and is being evaluated as a potential screening assay for EACs with effects on steroid biosynthesis. (thefreedictionary.com)
- The widely used angiotensin-II-responsive steroid-producing cell line H295R was originally isolated from a tumor diagnosed as adrenocortical carcinoma. (wikipedia.org)
- H295R (also referred to as NCI-H295R) is an angiotensin-II-responsive steroid-producing adrenocortical cell line. (wikipedia.org)
- All patients with suspected adrenocortical carcinoma should be carefully evaluated for signs and symptoms of hormonal syndromes. (wikipedia.org)
- Having certain genetic conditions increases the risk of adrenocortical carcinoma. (clevelandclinic.org)
- Approximately 60% of adrenocortical carcinomas produce hormones. (cigna.com)
- ACCs may be "functional", producing steroid hormones and consequent endocrine dysfunction similar to that seen in many adrenocortical adenomas, but many are not. (wikipedia.org)
- PDQ: adrenocortical carcinoma treatment - health professional version. (medlineplus.gov)
- Review: emerging treatment strategies for adrnocortical carcinoma: a new hope. (epnet.com)
- Adrenocortical carcinoma in the United States: treatment utilization and prognostic factors. (cigna.com)
- Mitotane was introduced in 1960 for the treatment of adrenocortical carcinoma. (wikipedia.org)
- Symptoms of adrenocortical carcinoma include pain in the abdomen. (clevelandclinic.org)
- A nonfunctioning adrenocortical tumor may not cause signs or symptoms in the early stages. (clevelandclinic.org)
- The tests and procedures used to diagnose adrenocortical carcinoma depend on the patient's signs and symptoms. (clevelandclinic.org)
- For decades, little progress was made in improving outcomes for patients with adrenocortical carcinoma (ACC). (springer.com)
- Adrenocortical carcinoma (ACC) is a rare tumor of the adrenal gland. (clinicaltrials.gov)
- Adrenocortical carcinoma (ACC) is a rare tumor that affects only 0.72 persons per one million population. (cigna.com)
- Adrenocortical carcinomas and adrenal pheochromocytomas: mass and enhancement loss evaluation at delayed contrast-enhanced CT. (thefreedictionary.com)
- Approximately 40% of people with adrenocortical carcinoma do not secrete any hormone. (portsmouthhospital.com)
- NCI does not have PDQ evidence-based information about prevention of adrenocortical carcinoma. (cancer.gov)
- Imaging studies and tests that examine the blood and urine are used to detect (find) and diagnose adrenocortical carcinoma. (clevelandclinic.org)
- A 64-year-old male was found to have a right adrenal incidentaloma during work-up for elevated liver transaminase levels, later found to be from hepatitis C. The mass was suspicious for adrenocortical carcinoma on CT imaging. (hindawi.com)
- As illustrated by this case, they appear similar to adrenocortical carcinoma on CT imaging. (hindawi.com)
- Biopsia de hígado por aspiración con aguja fina (1994) Características clínicas y evolución de la hipercalcemia grave por hiperparatiroidismo primario en pacientes intervenidos quirúrgicamente (2000) Accuracy of centinel node in papillary thyroid carcinoma (2001) Quality of life in bariatric surgery (2002) Utilidad de la laparoscopía con ultrasonido en la evaluación de resecabilidad de los tumores pancreáticos y ampulares. (wikipedia.org)
- There is also a loss of activity of the p57kip2 gene product in virilizing adenomas and adrenal cortical carcinomas. (wikipedia.org)
- In contrast, IGF-II gene expression has been shown to be high in adrenal cortical carcinomas. (wikipedia.org)
- Adrenocortical carcinoma has a bimodal distribution by age, with cases clustering in children under 5, and in adults 30-40 years old. (wikipedia.org)
- Adrenocortical carcinoma may present differently in children and adults. (wikipedia.org)
- The differential diagnosis of a renal tumor in a young patient with hypertension includes Juxtaglomerular cell tumor, Wilms' tumor, and renal cell carcinoma, all of which may produce renin. (wikipedia.org)
- ACTH acts by binding to cell surface ACTH receptors, which are located primarily on adrenocortical cells of the adrenal cortex. (wikipedia.org)
- Mineralisation is frequently associated with benign and malignant adrenocortical tumours in the dog and may aid in localising the adrenal. (vin.com)
- Nevoid basal cell carcinoma syndrome (NBCCS, Gorlin-Goltz syndrome) presents various symptoms and can disfigure patients. (diseaseinfosearch.org)
- Heterozygous PTCH1 Mutations Impact the Bone Metabolism in Patients With Nevoid Basal Cell Carcinoma Syndrome Likely by Regulating SPARC Expression. (diseaseinfosearch.org)
- Mitotane has been produced by Bristol Myers Squibb SpA but it is marketed as an orphan drug for adrenocortical carcinoma due to the small number of patients in need of it. (wikipedia.org)
- These actions are probably necessary to supply the enhanced energy needs of adrenocortical cells stimulated by ACTH. (wikipedia.org)
- Nevoid basal cell carcinoma syndrome (NBCCS) is a condition that increases the risk to develop various cancerous and noncancerous tumors. (diseaseinfosearch.org)
- Following organizations serve the condition "Nevoid basal cell carcinoma syndrome" for support, advocacy or research. (diseaseinfosearch.org)
- Mission: To provide educational and supportive services to persons affected with the manifestations of Basal Cell Carcinoma Nevus Syndrome, (a.k.a. (diseaseinfosearch.org)
- Finding the right clinical trial for Nevoid basal cell carcinoma syndrome can be challenging. (diseaseinfosearch.org)
- The terms "Nevoid basal cell carcinoma syndrome" returned 43 free, full-text research articles on human participants. (diseaseinfosearch.org)
- Nevoid Basal Cell Carcinoma Syndrome: Report from the Zurich Nevoid Basal Cell Carcinoma Syndrome Cohort. (diseaseinfosearch.org)
- Nevoid basal cell carcinoma syndrome (NBCCS) is an autosomal dominant disorder characterized by bone and skin abnormalities and a predisposition to various tumors. (diseaseinfosearch.org)
- Additional features of the syndrome included an excess of brain tumors (14 cases), leukemia (9 cases), and adrenocortical carcinoma (4 cases) before age 45 years. (wikipedia.org)
- Adrenocortical tumours may be function or non-functional and are difficult to differentiate ultrasonographically from tumours of the adrenal medulla (phaeochromocytoma). (vin.com)